Development and evaluation of African star apple (Chrysophyllum albidum) based food supplement and its potential in combating oxidative stress

Arueya, Gibson Lucky; Ugwu, Grace Febechi

doi:10.1016/j.jff.2017.04.004

Cited by 16 publications

(15 citation statements)

References 40 publications

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“…Therefore, the constituent polyphenols in the samples could largely contribute significantly to their antioxidant and enzyme inhibitory properties. While previous studies have reported the phenolic constituent and antioxidant properties of ASA fruit (Arueya & Ugwu, ; Asare et al, ; Oboh et al, ), to the best of our knowledge, this is the first time the phenolic constituents of different parts of this fruit will be characterized.…”

Section: Resultsmentioning

confidence: 76%

“…Also, Savithramm, Linga Rao, and Prabha () reported that C. albidium can be used as anti‐inflammatory, antisplasmodic, antianalgesic, and diuretic properties which can be attributed to their high flavonoids, steroids, glycosides, and saponins. Furthermore, previous studies have reported the phenolic constituent and antioxidant properties of African star apple fruit (Arueya & Ugwu, ; Asare, Okyere, Duah‐Bissiw, Ofosu, & Darfour, ), but to the best of our knowledge, polyphenol constituents of different parts of African star apple are yet to be characterized. Nevertheless, the antioxidant properties of African star apple could make them a viable therapy for prevention and management of several oxidative stress‐associated diseases including neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 95%

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Phenolic profiling and in vitro antioxidant, anticholinesterase, and antimonoamine oxidase properties of aqueous extract of African star apple (Chrysophyllum albidum) fruit parts

et al. 2018

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African star apple is a tropical edible fruit that is widely consumed among Nigerians. This present study investigated the antioxidant, anticholinesterase, and antimonoamine oxidase properties of African star apple fruit parts (flesh pulp, seed coat, and back coat) in vitro. The aqueous extracts of different parts were prepared. Thereafter, the effect on cholinesterases (acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]) and monoamine oxidase (MAO) activities and antioxidant potentials (1,1-diphenyl-2-picrylhydrazyl and hydroxyl) scavenging abilities and Fe 21 chelation abilities were investigated. Phenolic contents were also assayed for, and HPLC-DAD characterization of the phenolic constituents was carried out. The results revealed that the extracts inhibited AChE, BChE, and MAO activities and exhibited antioxidant properties. Also, there is abundance of caffeic acid, quercetin, chlorogenic acid and cyanidin as revealed by HPLC-DAD. In lieu of these findings, African star apple could be considered a cheap source of antioxidant and enzyme inhibitory compounds relevant in prevention/management of neurodegeneration. Practical applicationThe use of antioxidant, anticholinesterase and antimonoamine oxidase compounds has long been identified as useful therapeutic measures for the management of several neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Nevertheless, the several side effects of such synthetic compounds have limited their use and make natural biomolecules with similar therapeutic properties good alternatives. Here, we present the various fruit parts of African star apple as rich sources of antioxidants, as well as cholinesterase and monoamine oxidase inhibitors which could offer tremendous neuroprotective properties especially in the management of neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 95%

Phenolic profiling and in vitro antioxidant, anticholinesterase, and antimonoamine oxidase properties of aqueous extract of African star apple (Chrysophyllum albidum) fruit parts

et al. 2018

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“…Additionally, previous reports have revealed the phenolic constituent and antioxidant properties of African star fruit [ 15 , 19 , 20 ], but to the best of our knowledge, starch composition, estimated glycemic index (eGI), possible in vitro anti-hyperglycemic function of different parts of African star apple, and the likely biochemical mechanism that confirms their aptness as functional foods for managing of type-2 diabetes are yet to be elucidated. Accordingly, the current study aims to compare African star apple fruit parts, the pulp, cotyledon, seed coat and pulp coat (Fig.…”

Section: Introductionmentioning

confidence: 99%

Starch composition, glycemic indices, antioxidant properties and carbohydrate hydrolyzing enzymes activities of African star apple fruit parts

Ajayi

Oyetayo

Akomolafe

2020

BMC Complement Med Ther

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Background: African star apple (Chrysophyllum albidum) is a traditonal fruit, which is predominant in tropical regions with the fruit parts consumed by the populace and used in folklore to manage diabetes. However, the likely activity mechanism is still undetermined. The current study examined and compared the inhibitory abilities of African star apple fruit parts on selected key enzymes related to diabetes mellitus in the pancreas tissue of rat. Methods: Inhibitory effect of aqueous extract (1:10 w/v) of African star apple fruit parts (pulp, cotyledon, seed coat and pulp coat) on the activities of α-amylase, α-glucosidase, as well as their starch composition, phenolic constituents, estimated glycemic index, and antioxidant properties were assessed. Results: The fruit parts showed low sugar, eGI, amylose, and amylopectin contents. The analysis also showed that the fruit parts inhibited α-glucosidase and α-amylase activities and exhibited antioxidant properties. Furthermore, the fruit parts contain high concentrations of beta-amyrin acetate, eleagine, epicatechin, epigallocatechin, skatole, stigmasterol and tetrahydro − 2-methylharman as revealed by HPLC-DAD. Conclusion: The fruit part low estimated glycemic indices, strong antioxidant properties, inhibition of α-amylase and α-glucosidase activities exhibited might be related to the bioactive compounds contained in the extract. This could also be a potential mechanism for the use in the prevention and management of type-2 diabetes. Nevertheless, the African star apple pulp coat displayed the highest property in comparison to other parts of the fruit.

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“…The fruit is seasonal with immense economic potential, especially following the report that jams obtained from the fruit-pulp could compete with raspberry jams and jellies, while the oil from the seed has been used for diverse medicinal purposes [ 2 ]. Its rich sources of natural antioxidants have been established to promote health by acting against oxidative stress-related diseases such as diabetes, cancer, and coronary heart diseases [ 25 ]. The fruit-pulp has been reported to contain significant amount of ascorbic acid, vitamins, iron, food flavors, fat, carbohydrate and mineral elements [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines

Ajayi¹,

Chidebe²,

Ben‐Azu³

et al. 2020

Nutrire

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Purpose Fruit-based supplement has an important role in protecting the brain against oxido-inflammatory stress. Chrysophyllum albidum fruit contained several phytonutrients that possess antioxidants and anti-inflammatory properties. Hence, this study investigated the effect of C. albidum fruit supplemented diet (CAFD) on cognitive functions and lipopolysaccharide (LPS)-induced memory impairment and oxido-inflammatory response in mice. Methods Mice were randomized into two experiments. Experiment 1 with naïve mice contained four groups ( n = 6) while experiment 2 with LPS contains five groups ( n = 6). Mice in experiments 1 and 2 were fed on CAFD (5%, 10%, and 20%) in naïve (6 weeks) and LPS (250 μg/kg, i.p.) in the 7th week, respectively. Cognitive performance was tested using Y-maze test (YMT) and novel object recognition test (NORT) in the naïve and LPS mice. Brain samples were obtained for determination of oxido-inflammatory parameters and acetylcholinesterase activity. Results The CAFD significantly enhanced cognitive performance in the YMT and NORT in naïve and LPS mice, as evidenced by increased % alternation and discrimination index, respectively. CAFD supplementation significantly reduced acetylcholinesterase enzyme activity while it attenuated depletion of reduced glutathione and catalase activities in brains of naive and LPS-treated animals. The CAFD significantly reduced LPS-induced increased malondialdehyde levels in mice brains. CAFD supplementation significantly attenuated LPS-induced pro-inflammatory cytokines (IL-6, TNF-α) in mice brains. Conclusion Chrysophyllum albidum fruit supplementation in diet enhances memory function and prevents cognitive deficits induced by LPS via mechanisms associated with inhibition of oxidative stress-related processes, acetylcholinesterase activity, and pro-inflammatory mediators.

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Development and evaluation of African star apple (Chrysophyllum albidum) based food supplement and its potential in combating oxidative stress

Cited by 16 publications

References 40 publications

Phenolic profiling and in vitro antioxidant, anticholinesterase, and antimonoamine oxidase properties of aqueous extract of African star apple (Chrysophyllum albidum) fruit parts

Phenolic profiling and in vitro antioxidant, anticholinesterase, and antimonoamine oxidase properties of aqueous extract of African star apple (Chrysophyllum albidum) fruit parts

Starch composition, glycemic indices, antioxidant properties and carbohydrate hydrolyzing enzymes activities of African star apple fruit parts

Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines

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