Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing

Guidoni, Marcio; Figueira, Mariana Moreira; Ribeiro, Gabrielly Pereira; Lenz, Dominik; Grizotto, Pamela Aparecida; Pereira, Thiago de Melo Costa; Scherer, Rodrigo; Bogusz, Stanislau

doi:10.1007/s00403-019-01919-8

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…Active ointment was 20% Hypericum perforatum oil in petroleum jelly, while placebo ointment consisted of 20% mixture of vegetable oils used in Hypericum perforatum oil production (25% olive and 75% sunflower seed oil) in petroleum jelly with colour additives. Aforementioned plant oils were safely used in previous research 13,16 . Colour additives used were CI 14720; CI 16255; CI 19140; and CI 42051.…”

Section: Methodsmentioning

confidence: 99%

Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial

Leskur

Perišić

Romac

et al. 2020

Skin Research and Technology

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Introduction Human in vivo models of skin damage were often used in research of cutaneous disorders. The most commonly used models were tape‐stripping as mechanical, sodium lauryl sulphate‐induced irritation as chemical and ultraviolet radiation as physical damage model. In regard to differences between models, they were expected to have different responses to damage and recovery, with unique skin parameters’ changes over time. Objective The aim was to compare skin parameters in three different skin damage models on the same anatomical location, with and without topical treatment. Methods Four test sites on each forearm were randomly assigned to three skin damage models with the fourth sites on each forearm chosen as a control, undamaged site. Skin parameters were assessed using non‐invasive methods. Results Sodium lauryl sulphate irritation caused the strongest damage with delayed reaction to the irritant. Tape stripping leads to highest initial skin barrier disruption but afterwards it showed the fastest skin recovery. Ultraviolet radiation did not affect skin barrier function, but it elevated skin erythema and melanin level. Tested preparation did not lead to changes in measured parameters. Conclusion The skin of the participants had different response to three skin damage models with distinct changes of skin parameters and recovery. The trial was registered at ClinicalTrials.gov under the identifier NCT03783819.

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Section: Methodsmentioning

confidence: 99%

Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial

Leskur

Perišić

Romac

et al. 2020

Skin Research and Technology

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“…The aim of the insertion of the VO and Vegederm group was to demonstrate whether there would be any synergistic healing effect with the incorporation of VO in a dermo-cosmetic base (rich in antioxidants) with healing action previously developed by our research group [ 15 ]. Through the results obtained, this possible additional benefit was not observed in other studies [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the pilot study, concentrations above 5% did not allow good cream stability, probably due to excess amphoteric substances in the resin. This second incorporation of VO 5% was in a vegetable oil blend (Vegederm), also developed by Guidoni et al [ 15 ], which previously demonstrated a healing effect in skin-incised rats. The positive control used was the commercially available Dersani ® (linoleic, capric, caproic and caprylic acids, sunflower oil, soy lecithin, vitamin A and E).…”

Section: Methodsmentioning

confidence: 97%

“…In addition to unique species, vegetable oil blend formulations containing sunflower oil ( Helianthus annuus ), olive oil ( Olea europaea ), rosehip oil ( Rosa aff. rubiginosa ), linseed oil ( Linum usitatissimum ), black currant oil ( Ribes nigrum ), and macadamia oil ( Macadamia ternifolia nut oil ) also decrease the release of proinflammatory cytokines, reduce the migration of polymorphonuclear cells to the wound site, and promote proper deposition of the extracellular matrix, revealing an interesting healing effect [ 15 ]. In this study, the objective was to investigate whether a cream containing VO resin has healing activity in skin wounds in rats, justified at least in part, due to the high antioxidant effect.…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of Virola oleifera Formulation for Cutaneous Wound Healing

et al. 2022

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In regions adjacent to the Brazilian Atlantic Forest, Virola oleifera (VO) resin extract has been popularly used for decades as a skin and mucosal healing agent. However, this antioxidant-rich resin has not yet been investigated in wound healing, whose physiological process might also be aggravated by oxidative stress-related diseases (e.g., hypertension/diabetes). Our aim, therefore, was to investigate whether VO resin presents healing effects through an innovative cream for topical applications. For this, adult male Wistar rats were divided into four groups. Then, four 15 mm excisions were performed on the shaved skin. All treatments were applied topically to the wound area daily. At the end of experiments (0, 3rd, and 10th days) macroscopic analysis of wound tissue contraction and histological analysis of inflammatory cell parameters were performed. The group treated with VO cream showed the best wound contraction (15%, p < 0.05) and reduced levels of lipid peroxidation and protein oxidation (118% and 110%, p < 0.05, respectively) compared to the control group. Our results demonstrated the healing capacity of a new formulation prepared with VO, which could be, at least in part, justified by antioxidant mechanisms that contribute to re-epithelialization, becoming a promising dermo-cosmetic for the treatment of wound healing.

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“…The composition of the oleogel as a vehicle for betulin and lupeol was selected based on the results of the previous published studies [ 31 , 49 , 50 , 51 ]. Betulin and lupeol were incorporated in an oleogel vehicle based on a vegetable oils mixture of sunflower oil and olive oil in a 2:1 ratio.…”

Section: Discussionmentioning

confidence: 99%

Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation

et al. 2021

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The skin integrity is essential due to its pivotal role as a biological barrier against external noxious factors. Pentacyclic triterpenes stand as valuable plant-derived natural compounds in the treatment of skin injuries due to their anti-inflammatory, antioxidant, antimicrobial, and healing properties. Consequently, the primary aim of the current investigation was the development as well as the physicochemical and pharmaco-toxicological characterization of betulin- and lupeol-based oleogels (Bet OG and Lup OG) for topical application in skin injuries. The results revealed suitable pH as well as organoleptic, rheological, and textural properties. The penetration and permeation of Bet and Lup oleogels through porcine ear skin as well as the retention of both oleogels in the skin were demonstrated through ex vivo studies. In vitro, Bet OG and Lup OG showed good biocompatibility on HaCaT human immortalized cells. Moreover, Bet OG exerted a potent wound-healing property by stimulating the migration of the HaCaT cells. The in ovo results demonstrated the non-irritative potential of the developed formulations. Additionally, the undertaken in vivo investigation indicated a positive effect of oleogels treatment on skin parameters by increasing skin hydration and decreasing erythema. In conclusion, oleogel formulations are ideal for the local delivery of betulin and lupeol in skin disorders.

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Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing

Cited by 8 publications

References 26 publications

Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial

Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial

Development and Evaluation of Virola oleifera Formulation for Cutaneous Wound Healing

Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation

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