Development and Evaluation of a Novel Polymer Drug Delivery System Using Cromolyn-Polyamides-Disulfide using Response Surface Design

Abstract

The aim of this study was to employ nanoparticles as drug carriers. The research involved the design of cromolyn polyamide-disulfide nanocomposites to overcome the problem of frequent cromolyn doses and improve their properties. The cromolyn polyamide-disulfide samples were prepared using several amounts of cromolyn and sodium polyamide-disulfide polymer at different pH values. Analysis of variance (ANOVA) was performed to obtain the significant independent variables affecting the dependent response by using a P value lower than 0.05. The nanocomposites produced were characterized using Fourier transform infrared (FTIR) spectroscopy and in vitro release. An FTIR test was used to evaluate the functional groups of cromolyn in nanocomposites, which indicated that the drug was encapsulated inside the polymer. All data indicated the presence of cromolyn in the nanocomposites. The release profile of nanocomposites was found to be sustained. Therefore, the outcome of this research project could be a starting point for further work to optimize and assess polyamide-disulfide polymers for delivering another drug.

Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology

“…In addition, Figure 3(a) shows that the polymer had a very weak effect on loading efficiency by increasing the %LE with increasing concentration of that drug as expected due to the covalently bound and mechanically encapsulated forms of the polymer with the drug; this improves the stability and increases the loading of the drug [10]. Figure 3(a) also shows the relation between %LE and pH value.…”

“…The most common polymers used in drug delivery systems are chitosan [6,7], cyclodextrin [8], alginate [7,9], and polyamides and disulfide linkages [10]. However, more new polymer systems now exist that incorporate additional features for targeted delivery or combination therapies.…”

Quality by Design for the Synthesis and Optimisation of Arginine-Poly(Ester-Amide) Nanocapsules as Promising Carriers for Nose-Brain Delivery of Carbamazepine

“…The dilute solution viscosity of the (Arg-PEA) NCs was measured using an automated microviscometer (Anton Paar Ltd., St Albans, UK). A 1.8 mm capillary tube was employed in the measurement with a 1.5 mm steel ball (density 7.7 g/cm 3 ) and an inclination angle of 80 • . The viscometer was calibrated with the viscosity standard N26 from Paragon Scientific Ltd. (Birkenhead, UK).…”

“…They can rapidly cross the physiological barriers and reach the target sites at sufficient drug concentrations. In addition, their use is generally associated with fewer adverse effects when compared to many other drug delivery systems [1][2][3][4]. The use of a polymeric nanocapsules delivery system, nevertheless, requires the control of several features of the polymeric nanocapsules such as their composition, entrapment efficiency, loading efficiency, size distribution, drug release profile and stability [2][3][4][5][6][7][8].…”

“…In addition, their use is generally associated with fewer adverse effects when compared to many other drug delivery systems [1][2][3][4]. The use of a polymeric nanocapsules delivery system, nevertheless, requires the control of several features of the polymeric nanocapsules such as their composition, entrapment efficiency, loading efficiency, size distribution, drug release profile and stability [2][3][4][5][6][7][8]. Several factors, especially parameters used in the synthesis procedures, have dramatic effects on the quality and effectiveness of particular nanocapsules samples.…”