Development and Characterization of SRM Microspheres of Repaglinide

Abstract

The aim of current work to develop and evaluate sustained release mucoadhesive (SRM) microspheres of Repaglinide using emulsification solvent evaporation technique. Effects of formulation variables i.e. polymer concentration and phase volume ratio on particle size, % mucoadhesion and drug release were investigated in this study. Scanning electron microscopy of microspheres with maximum drug content (Formulation CH1:8) demonstrated smooth surface spherical particles with mean diameter of 64.78 ± 3.26 μm. The mean Particle size, % drug loading and mucoadhesion were found to vary by changing the formulation variables. Microspheres size was significantly increased as increasing the polymer concentration in the aqueous phase while size of microspheres decrease as increase in volume of continuous phase. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Repaglinide in sustained release manner for management of Type II Diabetes Mellitus.

Physicochemical Characterization of Artemether-Entrapped Solid Lipid Microparticles Prepared from Templated- Compritol and Capra hircus (Goat Fat) Homolipid

“…Batch C1 showed the lowest EE% and this might be due to the fact that it had the smallest mean particle size. 33 It was also observed that increase in the drug concentration for the various batches brought about a corresponding increase in the EE% implying that the lipid matrix promoted concentration dependent encapsulation. 34 In vitro drug release.…”

“…This can result to increase in the viscosity of the system which in turn would require more energy to breakdown the droplets of the disperse phase. 33 The drug encapsulation efficiency was evaluated using spectrophotometric method and the EE% of the SLM was in the range of 62.22-99.05%, with batch C3 having the highest EE (99.05%). Batch C1 showed the lowest EE% and this might be due to the fact that it had the smallest mean particle size.…”