Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide

Patel, Dinal; Patel, Viral

doi:10.1080/03639045.2021.1879832

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…The second plate was placed on the first plate, and a weight of 1 kg was placed on it and left for 5 min [ 39 ]. The spreadability of hydrogels and organogels was found by measuring the increasing diameter after 5 min and calculating with the equation given below [ 66 ]. The diameters obtained as a result of the spread were measured with the help of a manual caliper.…”

Section: Methodsmentioning

confidence: 99%

Nanoemulsion-Based Hydrogels and Organogels Containing Propolis and Dexpanthenol: Preparation, Characterization, and Comparative Evaluation of Stability, Antimicrobial, and Cytotoxic Properties

Özakar

Seyret

Özakar

et al. 2022

Gels

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Recently, nanoemulsion-based gels have become very popular for dermal drug delivery, overcoming the disadvantages of conventional semi-solid drug forms. The aim of this study is to prepare and characterize nanoemulsion-based hydrogels and organogels containing combined propolis and dexpanthenol, and to compare their stability, antimicrobial, and cytotoxicity properties. Within the scope of characterization studies, organoleptic properties, drug content, morphology, pH, gel-sol conversion temperature, spreadability, viscosity, FT-IR, and release properties were evaluated in hydrogels and organogels. The characterization studies carried out were subjected to short-term stability evaluation at room temperature and refrigerator for 3 months. While no phase separation was observed in any of the formulations kept in the refrigerator, phase separation was observed in four formulations kept at room temperature. The release study successfully obtained an extended release for propolis and dexpanthenol. In the antimicrobial susceptibility study, Hydrogel 1 showed activity against S. aureus, while Organogel 1 showed activity against both S. aureus and S. epidermidis. In the cytotoxicity study against HDFa cells, both Hydrogel 1 and Organogel 1 were found to be nontoxic at low doses. These hydrogels and organogels, which contain propolis and dexpanthenol in combination for the first time, are promising systems that can be used in wound and burn models in the future.

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Section: Methodsmentioning

confidence: 99%

Nanoemulsion-Based Hydrogels and Organogels Containing Propolis and Dexpanthenol: Preparation, Characterization, and Comparative Evaluation of Stability, Antimicrobial, and Cytotoxic Properties

Özakar

Seyret

Özakar

et al. 2022

Gels

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show abstract

“…A further study investigated the utilization of an organogel formulation containing a topical corticosteroid, fluocinolone acetonide, as a therapeutic regimen for the treatment of psoriasis. 155 The ex vivo drug release lasted for up to 6 h, with a release profile of 90.64%, which was shown to be protracted compared to that of the commercially available preparation. Additionally, a higher cutaneous disposition was observed.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 97%

“…In vitro transcutaneous delivery of the anti-inflammatory drug ketoprofen in combination with other unsaturated fatty acids from a lecithin organogel containing fish oil was reported . Studies showed that a substantial amount of ketoprofen was delivered across the full-thickness porcine skin from the lecithin organogel formulation for up to 24 h. In another reported work, the delivery of a topical corticosteroid, fluocinolone acetonide, was sustained from the lecithin organogel formulation as the regimen for skin inflammation . The delivery of fluconazole and diclofenac diethylamine was enhanced in combination with cellulose derivatives (hydroxypropyl methyl cellulose and hydroxypropyl cellulose) from a lecithin microemulsion-based organogel formulation .…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

“…The results of this study can be applied to enhance the LO systems of various medications, hence improving the safety and efficacy of topical drug administration. A further study investigated the utilization of an organogel formulation containing a topical corticosteroid, fluocinolone acetonide, as a therapeutic regimen for the treatment of psoriasis . The ex vivo drug release lasted for up to 6 h, with a release profile of 90.64%, which was shown to be protracted compared to that of the commercially available preparation.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

“… 162 Studies showed that a substantial amount of ketoprofen was delivered across the full-thickness porcine skin from the lecithin organogel formulation for up to 24 h. In another reported work, the delivery of a topical corticosteroid, fluocinolone acetonide, was sustained from the lecithin organogel formulation as the regimen for skin inflammation. 155 The delivery of fluconazole and diclofenac diethylamine was enhanced in combination with cellulose derivatives (hydroxypropyl methyl cellulose and hydroxypropyl cellulose) from a lecithin microemulsion-based organogel formulation. 163 The application of lecithin organogels has also been explored in the field of viral skin diseases.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

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Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

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Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

Dave,

Kariya,

Dudhat

2024

J Pharm Innov

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Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide

Cited by 8 publications

References 13 publications

Nanoemulsion-Based Hydrogels and Organogels Containing Propolis and Dexpanthenol: Preparation, Characterization, and Comparative Evaluation of Stability, Antimicrobial, and Cytotoxic Properties

Nanoemulsion-Based Hydrogels and Organogels Containing Propolis and Dexpanthenol: Preparation, Characterization, and Comparative Evaluation of Stability, Antimicrobial, and Cytotoxic Properties

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

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