Development and Characterization of Plant Oil-Based Potent Anticholinesterase Microemulsion Containing Withania Somnifera Extract With Enhanced Transdermal Delivery of Phytoconstituents for the Treatment of Cognitive Disorders
Abstract:Objective: This work was carried out to develop Cymbopogan Citratus (lemon grass)oil based microemulsion formulation loaded with the extract of Withania somnifera which possess enhanced transdermal delivery of phytoconstituents with anticholinesterase activity useful in treating Alzheimer’s disease.
Methods: Methanolic extract of Withania somnifera roots were prepared and it was investigated for the inhibition of acetylcholinesterase (AChE) activity by Ellman’s assay. Based on the acetylcholinesterase activity… Show more
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