Development and characterization of pH-responsive nanocarriers for chemo-photothermal combination therapy of acidic tumors

Husni, Patihul; Shin, Yuseon; Jeon, Hyewon; Lee, Eun Seong; Youn, Yu Seok; Poon, Chi‐Duen; Lim, Chaemin; Oh, Kyung Taek

doi:10.1016/j.jconrel.2023.05.025

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Multiple stimulus-responsive nanocarriers have shown a high degree of control over drug delivery and release, resulting in improved anticancer efficacy in vitro and in vivo [80]. For example, smart nanocarriers, which are sensitive to pH, temperature and redox conditions, can cause carrier materials to decompose and nanocarriers to cleave at critical high temperatures, low pH, etc [81,82]. Zhao et al utilized peptidyl lipids and sucrose laurate to modify carbon nanotubes, both of which exhibit temperature sensitivity, resulting in the formation of a stable and safe nanocarrier delivery system.…”

Section: Dual and Multiple Stimulus-responsive Drug Deliverymentioning

confidence: 99%

Advances in the variations and biomedical applications of stimuli-responsive nanodrug delivery systems

Gong,

Peng,

Cao

et al. 2024

Nanotechnology

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Chemotherapy is an important cancer treatment modality, but the clinical utility of chemotherapeutics is limited by their toxic side effects, inadequate distribution and insufficient intracellular concentrations. Nanodrug delivery systems (NDDSs) have shown significant advantages in cancer diagnosis and treatment. Variable NDDSs that respond to endogenous and exogenous triggers have attracted much research interest. Here, we summarized nanomaterials commonly used for tumor therapy, such as peptides, liposomes, and carbon nanotubes, as well as the responses of NDDSs to pH, enzymes, magnetic fields, light, and multiple stimuli. Specifically, well-designed NDDSs can change in size or morphology or rupture when induced by one or more stimuli. The varying responses of NDDSs to stimulation contribute to the molecular design and development of novel NDDSs, providing new ideas for improving drug penetration and accumulation, inhibiting tumor resistance and metastasis, and enhancing immunotherapy.

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Section: Dual and Multiple Stimulus-responsive Drug Deliverymentioning

confidence: 99%

Advances in the variations and biomedical applications of stimuli-responsive nanodrug delivery systems

Gong,

Peng,

Cao

et al. 2024

Nanotechnology

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“…The introduction of stimulus-responsive chemical groups to nanomedicines is thus a more versatile approach. [25] Tremendous stimuli-responsive polymers capable of responding to the tumor microenvironment signals including pH, [26][27][28] temperature, [29,30] reactive oxy-gen species, [31][32][33] and glutathione (GSH) [34,35] have been developed so far. Of the reported stimuli approaches, the application of GSH-sensitive polymers containing disulfide bridges is of particular importance owing to the distinct difference in the GSH levels between normal cells (≈2 mm) and specific tumor cells (≈10 mm).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Zhang,

Ma,

Wang

et al. 2023

Macro Chemistry & Physics

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Poly(tertiary amine‐oxide)‐based polymeric nanocarriers have showed more functionalities than stealthy PEG‐based analogs due to the structure of phospholipid affinitive N‐oxides groups, which has attracted considerable attention to the synthesis of various zwitterionic copolymers with tertiary amine‐oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amine‐oxide)‐based amphiphilic copolymers with tumor intracellular microenvironment sensitivities, to the knowledge, have been rarely reported likely due to the lack of a controlled synthetic strategy. Herein, a reducible zwitterionic copolymer, poly(ε‐caprolactone)25‐SS‐poly(2‐(N‐oxide‐N,N‐diethylamino)ethyl methacrylate)30 (PCL25‐SS‐OPDEA30) is designed and synthesized successfully via combination of controlled polymerization techniques and post polymerization modification. Specifically, postoxidation of poly(tertiary amine) is confirmed to be a better synthetic strategy toward a well‐defined polymer structure relative to direct polymerization of N,N‐diethylaminoethyl methacrylate (ODEA). The effect of disulfide bridges on the self‐assembly behaviors, in vitro drug loading and drug release properties is investigated in detail. Notablely, the resulting micelles self‐assembled from PCL25‐SS‐OPDEA30 show much greater colloidal stability, higher drug loading content (DLC), and better in vitro tumor cell inhibition than the reduction‐insensitive counterparts. Overall, this study reports a robust strategy toward zwitterionic nanomedicines for on‐demand anticancer drug delivery.

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Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy

Hu,

Shen,

Wang

et al. 2024

Chinese Chemical Letters

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Development and characterization of pH-responsive nanocarriers for chemo-photothermal combination therapy of acidic tumors

Cited by 6 publications

References 57 publications

Advances in the variations and biomedical applications of stimuli-responsive nanodrug delivery systems

Advances in the variations and biomedical applications of stimuli-responsive nanodrug delivery systems

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy

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