Development and Characterization of Novel Medicated Hydrogels for Wound Dressing

Abstract

□ The medicated hydrogels were prepared aseptically under moist heat treatment using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerin and/or boric acid (BA) and designated as PVP-CMC and PVP-CMC-BA. The aim of this study was to develop some medicinal values-based hydrogels. BA was used to build up the medicinal values (antiseptic and antimicrobial properties) within the hydrogels. Optical images, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy of the hydrogels indicated that boric acid is uniformly dispersed within the cross-linked hydrogel network that may heal and protect the wounds from infections/sepsis. Swelling study in presence of water and physiological saline solution confirmed its reasonable absorption capacity. The rheological properties and mechanical properties demonstrated that the boric acid incorporated hydrogels are quite flexible. Assessment of antimicrobial property study proves that PVP-CMC-BA (3 % BA) has strong infection protection capacity.Keywords Boric acid, Hydrogels, Swelling, Viscoelastic properties, Wound dressing INTRODUCTIONThe medicated hydrogels are the hydrogels that possess some medicinal value within them. They are cross-linked polymeric gels that have water-holding and nonadhering properties. Hydrogels can be prepared with monomers, prepolymers, or existing hydrophilic polymers as starting materials. They are generally specified by two component systems. One of the components is hydrophilic, which has water insoluble three-dimensional polymer networks, and the second component is water. They may swell in water up to a large extent and reach the equilibrium state while retaining their original shape (1).In fact, a hydrogel is considered as a kind of cheap, effective, convenient material for wound dressing, due to its good biocompatibility, water absorption ability, moisture retention, and ventilating capacity (2). They are closely resembled to living tissue in their physical properties because of their relatively high water content as well as soft and rubbery consistency (3). Numerous research studies have established that a moist wound environment is most favorable for healing (4). Hydrogel wound burn dressings were first invented by Rosiak et al. in 1989, which have many interesting properties, such as immediate pain control, easy replacement, transparency, absorption, prevention of loss of body fluids, barrier against bacteria, good adhesion, easy handling, oxygen permeability, control of drug dosage, and so on (3,5,6).The hydrogel dressings are usually directly applied to the wounds, thus the biocompatibility and non-toxicity factors are required to be taken into consideration. Polyvinylpyrrolidone (PVP) is a well-known polymer with good biocompatibility; hence, this polymer can be used as one of the main components of pseudo hydrogel preparation for temporary skin covers or wound dressings (6, 7). PVP is used in production of medicines and serves as blood substitute and blood d...

Effect of Strain on Viscoelastic Behavior of PVP-CMC Based Medicated Hydrogels

“…The experiments were carried out using the freshly prepared and swelled hydrogels (the dry hydrogel films were swollen for 60 min in distilled water), and designated as "fresh" and "swelled" hydrogels respectively for both PVP-CMC and PVP-CMC-BA. In our previous articles we had established that after 60 min of swelling from dry state, the hydrogels regain quite similar properties with the fresh hydrogels [3,4]. The optical view of the hydrogels (fresh, dry and swelled) is shown in Figure 1.…”

“…PVP-CMC and PVP-CMC-BA hydrogels were prepared using moist heat treatment using polyvinylpyrrolidone (PVP), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), agar, and glycerin, without or with boric acid (BA), respectively [3][4][5]. The composition of PVP-CMC and PVP-CMC-BA are depicted in Table 1.…”

“…Wound healing is a dynamic process and a dressing can enhance the progress of healing. Motivated by these interesting features of hydrogels and its demand in health care purposes we prepared a simple technology oriented biopolymer based novel medicated hydrogels which is human friendly, biocompatible, medicinal value-added, moreover appropriate to be used as dressing materials [3][4][5]. Many different kinds of hydrogels and their efficiency in biomedical application have been reported through the years [6][7][8][9].…”

Mineralized polymer composites as biogenic bone substitute material

“…The osmotic pressure of the physiological solution is equivalent to human blood tissue [15]. Four different thicknesses (100,200,300,400μm) of mineralized hydrogels i.e.…”

Viscoelastic Properties and Morphology of Mumio-based Medicated Hydrogels

“…The mumio based medicated hydrogels were prepared by moist heat treatment [9,13] using aqueous solution of PVA, agar, mumio and MM or SB oil or SA. Five different polymeric solutions were prepared by varying the healing ingredients and keeping the amount of PVA and agar components constant.…”