Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential

Elkhalifa, Abd Elmoneim O.; Al-Shammari, Eyad; Adnan, Mohd; Alcantara, Jerold C.; Mehmood, Khalid; Eltoum, Nagat Elzein; Awadelkareem, Amir Mahgoub; Khan, Mushtaq Ahmad; Ashraf, Syed Amir

doi:10.3390/molecules26123609

Cited by 20 publications

(17 citation statements)

References 43 publications

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“…A high degree of swelling activity may lead to excessive hydration, reducing the interaction between mucoadhesive polymers due to low bioadhesiveness [56]. According to previous research, the swelling factor increased with the increase in pH and time [57,58].…”

Section: )mentioning

confidence: 97%

Characterization, Antioxidant Activities, and Functional Properties of Mucilage Extracted from Corchorus olitorius L.

Kim

2022

Polymers

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This study extracted the mucilage from Corchorus olitorius L. to observe its chemical and functional properties and suggest its possible applications in various fields. Corchorus olitorius L. mucilage was isolated by hot water extraction. FT-IR and HPAEC-PAD were used to describe the chemical composition, and the functional properties and antioxidant activities of the mucilage were also examined. The mucilage was mainly composed of uronic acid (34.24%, w/w). The solubility was 79.48 ± 1.08% at 65 °C, the swelling index was 29.01 ± 2.54% at 25 °C, and the water-holding capacity and oil-binding capacity were 28.66 ± 1.48 and 8.423 ± 0.23 g/g, respectively. The mucilage viscosity increased from 4.38 to 154.97 cP in a concentration-dependent manner. Increasing the concentration decreased the emulsion activity and increased the emulsion stability, most likely because of the corresponding increase in surface tension and viscosity. Results from antioxidant assays confirmed that the in-vitro radical scavenging activity of the mucilage increased with concentration. This study shows that C. olitorius L. can be utilized as a new hydrocolloid source, with potential applications in fields ranging from foods to cosmetics and pharmaceuticals.

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Section: )mentioning

confidence: 97%

Characterization, Antioxidant Activities, and Functional Properties of Mucilage Extracted from Corchorus olitorius L.

Kim

2022

Polymers

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“…According to the International Diabetes Federation (IDF), Egypt is among the top ten nations globally in terms of diabetes patients. It is expected that the number of diabetic patients in the Middle East and North Africa (MENA) region is predicted to increase by 96%, from 34.6 million to 67.9 million from 2013 to 2035 36, 37 . In Egypt, diabetes affects 15.56% of individuals aged 20 to 79 years old, resulting in an annual mortality toll of 86,478 people with type-2 diabetes accounting for more than 90% of cases of type 2 diabetes (T2DM) 34 .…”

Section: The Role Of Diabetesmentioning

confidence: 99%

The link between black fungus and Covid-19 disease in diabetes mellitus patients

et al. 2021

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Introduction:The emergence of the novel coronavirus disease (COVID-19) pandemic has conditioned the whole world to search for an ultimate cure for the infection. Therefore, all countries with no exception have embraced vaccines in addition to other pharmacological drugs. The consequences of the pandemic include material and human losses in all countries. Another emerging disease is a black fungus. The black fungus is a pathological phenomenon that arises as a result of exposure to mucormycosis. It is observed concurrently with recovery from the virus. The infection has symptoms and risks that do not reduce the risk of infection by COVID-19. Methods: Information was gathered from the review of the relevant literature obtained from various databases, such as Science Direct, Springer, PubMed, Google, and Google Scholar. Results: The relationship between diabetes, COVID-19, and mucous fungus is such that diabetes weakens the immune system which helps the COVID-19 virus. Conclusion: The decline of the immune system facilitates secondary infections such as the mucous fungus, especially in the recovery phase from the virus. Therefore, in this review, information about the new pandemic and its risks have been summarized.

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“…Young okra pods are commonly eaten as vegetables and raw materials for polysaccharide extraction, okra seeds are utilized for oil and protein extraction, and aging fruit pods are served as animal feed ( Fekadu Gemede, 2015 ). In particular, young okra pods are delicious, tender and lubricating, low in energy, free of oil, and contains high okra polysaccharide, rich in carotene, vitamin C, a variety of B vitamins and mineral elements such as Fe, Mn, and Zn, as well as rich phenolic compounds, such as oligocatechin and hydroxybenzoic acid derivatives ( Elkhalifa et al, 2021b ; Uddin Zim et al, 2021 ). However, due to the various microbial factors and plant characteristics, okra is particularly susceptible to spoilage during postharvest storage ( Tsado, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Mechanism of Thymol/KGM/LG Edible Coating Solution on Inhibition of Mucor circinelloides Isolated From Okra

Zhang

Wen

et al. 2022

Front. Microbiol.

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With the increasing demand and quality requirement for the natural nutritious food in modern society, okra has attracted much attention because of its high nutritional value and remarkable functionality. However, the occurrence of postharvest diseases of fresh okra severely limited the application and the value of okra. Therefore, in this study, the dominant pathogens causing postharvest diseases such as soft rot were isolated from naturally decaying okra. It was identified as Mucor circinelloides by its morphological characteristics and standard internal transcribed spacer ribosomal DNA sequence. Furthermore, the biological characteristics of M. circinelloides were studied, and the inhibitory effect of thymol/KGM/LG (TKL) edible coating solution on M. circinelloides and its possible mechanism was discussed. In addition, TKL edible coating solution had a dose-dependent inhibitory effect on M. circinelloides, with a 50% inhibitory concentration (EC50) of 113.55 mg/L. The TKL edible coating solution at 960 mg/L of thymol completely inhibited mycelial growth and spore germination of M. circinelloides. The results showed that the best carbon source of M. circinelloides was maltose, the best nitrogen source was beef extract and potassium nitrate, the best pH was 6, the best temperature was 28°C, the best NaCl concentration was 0.5%, and the light was conducive to the growth of M. circinelloides. It was also observed by scanning electron microscope (SEM) that TKL was more likely to destroy the cell wall integrity of M. circinelloides, inhibit spore morphology and change mycelium structure. Meanwhile, the activity of chitinase (CHI), an enzyme related to cell wall synthesis of M. circinelloides, was significantly decreased after being treated by TKL with thymol at 100 mg/L (TKL100). The content of Malondialdehyde (MDA) in M. circinelloides decreased significantly from 12 h to 48 h, which may cause oxidative damage to the cell membrane. The activity polygalacturonase (PG), pectin methylgalacturonase (PMG), and cellulase (Cx) of M. circinelloides decreased significantly. Therefore, the results showed that TKL had a good bacteriostatic effect on okra soft rot pathogen, and the main bacteriostatic mechanism might be the damage of cell membrane, degradation of the cell wall, inhibition of metabolic activities, and reduction of metabolites, which is helpful to further understand the inhibitory effect of TKL on okra soft rot pathogen and its mechanism.

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Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential

Cited by 20 publications

References 43 publications

Characterization, Antioxidant Activities, and Functional Properties of Mucilage Extracted from Corchorus olitorius L.

Characterization, Antioxidant Activities, and Functional Properties of Mucilage Extracted from Corchorus olitorius L.

The link between black fungus and Covid-19 disease in diabetes mellitus patients

Efficacy and Mechanism of Thymol/KGM/LG Edible Coating Solution on Inhibition of Mucor circinelloides Isolated From Okra

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