Development and characterization of novel alginate-based hydrogels as vehicles for bone substitutes

Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

“…3A and B, time 30-60 min), which transformed GG-NPs-Aln into a flowing sol (both G 0 and G 00 decreased drastically and G 00 became higher than G 0 ). The drop in both moduli (G 0 , G 00 ) was due to structural changes within the gel network: possibly cross-links destruction or an alignment of hydrogel chains occurred as shown in other studies (Morais et al, 2013). The G' of the GG-NPs-Aln system dropped much faster than the G 0 of GG when strain deformations were applied (see Fig.…”

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

“…Particularly, natural polymers exhibit high biocompatibility and low tissue damage [30,32]. Among available natural, biocompatible polymers, alginates are widely used in tissue engineering [33 -39] and drug delivery [37,[39][40][41], because of their ability to form hydrogels when multivalent cations react with their guluronic residues [40,42]. As cross-linked alginate gels degrade, cross-linking ions are released due to the exchange with monovalent cations from the media [42].…”

Gellan Gum‐based Hydrogels for Tissue Engineering Applications

“…Bearing this requirement in mind, an in situ forming and injectable hydrogel scaffold may provide many advantages. Thus, hydrogel-based composite biomaterials have been proposed for bone tissue engineering [58][59][60]. Similarly, GG-hydroxyapatite scaffolds have been produced by Manda-Guiba et al [61] by means of using a freeze-drying method.…”