Development and characterization of novel photopolymerizable formulations for stereolithography

Corcione, Carola Esposito

doi:10.1515/polyeng-2013-0224

Cited by 15 publications

(4 citation statements)

References 32 publications

(37 reference statements)

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“…This variability in mass could be due to the multiple factors both from the liquid formulation and the settings of the printer. The number of laser passes for each printed layer and the laser power directly affect the curing depth, and hence, the properties of the printed layer [63]. Hence, the parameters need to be optimised for each resin type.…”

Section: Resultsmentioning

confidence: 99%

3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

et al. 2019

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Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with different geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills.

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Section: Resultsmentioning

confidence: 99%

3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

et al. 2019

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“…Lately, the materialization of nanocomposites through enhancing photopolymerization has engrossed a huge amount of attention of researchers. In particular, there is a vast consideration based on the nano distribution phases comprising nanosized metals [33][34][35][36][37][38][39]. The metal oxide-based semiconductor nanoparticle has been the focus of substantial research attention in recent years [40].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Mechanical and Thermal Properties of Stereolithography 3D Printed Structures by the Effects of Incorporated Controllably Annealed Anatase TiO2 Nanoparticles

et al. 2020

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Fabrication of low-cost, durable and efficient metal oxide nanocomposites were successfully synthesized and reinforced with photo-resin via 3-dimensional printing. Here, we put forward a novel approach to enhance the mechanical and thermal behaviors of stereolithography (SLA) 3D printed architecture by adding TiO2 nanoparticles (TNPs) in different crystalline phases (anatase and rutile), which were obtained at different annealing temperatures from 400 °C to 1000°C. The heat-treated anatase TNPs were scrutinized by X-ray diffraction(XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, diffusive reflectance spectroscopy (DRS), and transmission electron microscopy (TEM) analysis. Among all the samples, at 800 °C, annealed anatase TNPs exposed a highly crystalline anatase phase, having a low energy bandgap and a comparably high tensile strength (47.43 MPa) and high elastic modulus (2.261 GPa) for the 3D printed samples, showing improvement by 103% and 32%, respectively, compared with the printed pristine stereolithography resin (SLR) sample. Moreover, enhanced storage modulus and tan δ values were achieved via the better interfacial interactions between the incorporated nanofillers and the SLR matrix. In addition to this, enhanced thermal conductivity and thermal stability of the SLR matrix were also noted. The low energy bandgap and nanoscale size of the fillers helped to achieve good dispersion and allowed the UV light to penetrate at a maximum depth through the photo resin.

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“…The resolution of these techniques is influenced by many factors, depending both on the photocurable system (curing mechanism, kinetics, free radical diffusion, etc.) [ 33 , 34 , 35 ] and the optical system [ 36 ]. The throughput of the SLA process is slow due to the point-by-point scanning nature of the direct-write of the laser system while the DLP exploits a digital micro mirror-array device (DMD), to produce a dynamic digital mask: An entire part cross section can be cured at one time, resulting in a faster process than scanning a laser beam [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

In Situ Thermal Generation of Silver Nanoparticles in 3D Printed Polymeric Structures

et al. 2016

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Polymer nanocomposites have always attracted the interest of researchers and industry because of their potential combination of properties from both the nanofillers and the hosting matrix. Gathering nanomaterials and 3D printing could offer clear advantages and numerous new opportunities in several application fields. Embedding nanofillers in a polymeric matrix could improve the final material properties but usually the printing process gets more difficult. Considering this drawback, in this paper we propose a method to obtain polymer nanocomposites by in situ generation of nanoparticles after the printing process. 3D structures were fabricated through a Digital Light Processing (DLP) system by disolving metal salts in the starting liquid formulation. The 3D fabrication is followed by a thermal treatment in order to induce in situ generation of metal nanoparticles (NPs) in the polymer matrix. Comprehensive studies were systematically performed on the thermo-mechanical characteristics, morphology and electrical properties of the 3D printed nanocomposites.

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Development and characterization of novel photopolymerizable formulations for stereolithography

Cited by 15 publications

References 32 publications

3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

Enhanced Mechanical and Thermal Properties of Stereolithography 3D Printed Structures by the Effects of Incorporated Controllably Annealed Anatase TiO2 Nanoparticles

In Situ Thermal Generation of Silver Nanoparticles in 3D Printed Polymeric Structures

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