Development and Characterization of Multifunctional Wound Dressing with the Property of Anti-bacteria and Angiogenesis

He, Xi; Zhou, Meiling; Wang, Jing; Zhao, Xiaoli; Zhu, Yanxia; Liu, Tao

doi:10.1007/s12602-022-09914-8

Cited by 6 publications

(5 citation statements)

References 40 publications

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“…Our results suggested that MDSCs were effectively cleared from the tumor tissue due to the improvement of local chemotherapy delivery efficiency of the sustained-release materials, thereby restoring the normal recruitment and differentiation ability of CD8 + T cells and NKp46 + NK cells in the tumor tissue, enhancing the anti-tumor effect of the autoimmune system. Moreover, based on the study of angiogenesis, slow-release materials can also effectively inhibit tumor microvascular formation within the tissue, thereby further restricting tumor growth [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Wang,

Yin,

Ren

et al. 2024

J Mater Sci: Mater Med

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The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Wang,

Yin,

Ren

et al. 2024

J Mater Sci: Mater Med

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“…During the wound healing process, the promotion of angiogenesis and restoration of trauma are necessary and include the proliferation and migration of keratinocytes, the proliferation of fibroblasts, matrix deposition, and angiogenesis [23][24][25][26]. Fibroblasts further stimulate keratinocyte proliferation and migration through KGF, EGF, and fibronectin, a process enhanced by the presence of VEGF and FGF-β [27][28][29], while a wide variety of other cells, such as neutrophils and macrophages, contribute by releasing CXCL2, CXCL3, PDGF, VEGF, TGF-α, TGF-β, TNF-α, and interleukins IL-1β, IL-6, IL-8 and IL-10 [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin

et al. 2023

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The probiotics Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 seem to promote wound healing when applied topically. Our aim was to investigate their effect on the mRNA expression of pro-inflammatory, healing and angiogenetic factors during the healing process of a standardized excisional wound model in rats. Rats subjected to six dorsal skin wounds were allocated to Control; L. plantarum; combined formula of L. rhamnosus plus B. longum; L. rhamnosus; and B. longum treatments, applied every two days, along with tissue collection. The pro-inflammatory, wound-healing, and angiogenetic factors of mRNA expression were assessed by qRT-PCR. We found that L. plantarum exerts a strong anti-inflammatory effect in relation to L. rhamnosus–B. longum, given alone or in combination; the combined regime of L. rhamnosus–B. longum, works better, greatly promoting the expression of healing and angiogenic factors than L. plantarum. When separately tested, L. rhamnosus was found to work better than B. longum in promoting the expression of healing factors, while B. longum seems stronger than L. rhamnosus in the expression of angiogenic factors. We, therefore, suggest that an ideal probiotic treatment should definitively contain more than one probiotic strain to speed up all three healing phases.

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“…of the important factors leading to slow wound healing, and appropriate antibacterial wound dressing is an important approach to prevent microbial infection and also a necessary condition to accelerate wound healing [97]. The dressings should support the sustained drug release of loaded antimicrobials to achieve long-term antimicrobial activity and maintain a healthy concentration of healing tissues [98].…”

Section: Wound Dressing and Healing Microbial Infection Is Onementioning

confidence: 99%

Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

Shen

Zhang

Mao

et al. 2022

International Journal of Polymer Science

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By 2050, it is estimated that 10 million people will die of drug-resistant bacterial infection caused by antibiotic abuse. Antimicrobial peptide (AMP) is widely used to prevent such circumstances, for the positively charged AMPs can kill drug-resistant bacteria by destroying negatively charged bacterial cell membrane, and has excellent antibacterial efficiency and low drug resistance. However, due to the defects in low in vivo stability, easy degradation, and certain cytotoxicity, its practical clinical application is limited. The emergence of peptide–polymer conjugates (PPC) helps AMPs overcome these shortcomings. By combining with functional polymers, the positive charge of AMPs is partially shielded, and its stability and water solubility are improved, so as to prolong the in vivo circulation time of AMPs and reduce its cytotoxicity. At the same time, the self-assembly ability of PPC enables it to assemble into different nanostructures to undertake specific antibacterial tasks. At present, PPC is mainly used in wound dressing, bone tissue repair, antibacterial coating of medical devices, nerve repair, tumor treatment, and oral health maintenance. In this study, we summarize the structure, synthesis methods, and the clinical applications of PPC, so as to present the current challenges and discuss the future prospects of antibacterial therapeutic materials.

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Development and Characterization of Multifunctional Wound Dressing with the Property of Anti-bacteria and Angiogenesis

Cited by 6 publications

References 40 publications

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin

Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

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