Development and characterization of electrospun curcumin-loaded antimicrobial nanofibrous membranes

Abstract

Curcumin is a naturally occurring hydrophobic polyphenol compound. It exhibits a wide range of biological activities such as antibacterial, anti-inflammatory, anti-carcinogenic, antifungal, anti-HIV, and antimicrobial activity. In this research work, antimicrobial curcumin nanofibrous membranes are produce by an electrospinning technique using the Eudragit RS 100 (C19H34ClNO6) polymer solution enriched with curcumin. The morphology and chemistry of the membrane are analyzed using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Kirby Bauer disk diffusion tests are carried out to examine the antibacterial effectiveness of the membrane. Experimental results show that the nanofibers produced are of uniform thickness morphology and curcumin is successfully incorporated into the nanofibrous mat, while no chemical bonding was observed between curcumin and the polymer. The antimicrobial curcumin nanofibrous membranes can be effectively applied as antimicrobial barrier in a wide variety of medical applications such as wound healing, scaffolds, and tissue engineering.

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

“…A recent study 66 describes an electrospun nanofibrous scaffold based on the copolymer of acrylic and methacrylic acid esters Eudragit RS100 (C 19 H 34 ClNO 6 ). Interestingly, the authors used needleless electrospinning equipment with an intermediate rotary disc partially immersed into a solution bath.…”

Catechol-Based Antimicrobial Polymers

“…Other natural polyphenols such as tea catechins, curcumin from Curcuma longa , and procyanidins from grape seeds exhibit anti-tumor, anti-inflammatory, antioxidant, anti-obesity, and antimicrobial properties [ 107 , 108 , 109 , 110 , 111 , 112 ]. For example, theaflavin digallate (TFDG), a poly-catechin, can directly inhibit cytoplasmic membrane proteins to achieve an antimicrobial effect [ 113 ].…”

“…The membrane glucose transporters’ activity decreased 40% after treatment with 62.5 mg·L −1 TFDG. Similarly, nanofibrous membranes constructed from curcumin-containing polymer demonstrated to be effective antimicrobial barriers with antimicrobial activity that lasted over 7 days [ 111 ]. Procyanidins can serve as an antimicrobial drug [ 114 ].…”

Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings

“…The strategic development of drug delivery systems also emerges as a viable solution to enhance antibiotic administration, aiming for local delivery and optimal concentration, to attenuate their concentration in healthy tissues. ,,− Polymer nanofibers (NFs) have shown promise as drug carriers and, besides that, nanofibrous mats have exhibited properties, such as high surface area-to-volume ratio, high porosity, and similarity to the extracellular matrix, which make them very interesting substrates for wound healing applications. − The solution blow spinning (SBS) technique, illustrated in Scheme , allows the development of large self-standing nanofibrous mats, in a quick and reproducible way, using small amounts of reagents and a low-cost apparatus. , This technique has been shown to be suitable for the biocompatible polymer poly(ε-caprolactone) (PCL), an important material for the field of regenerative medicine and approved by the Food and Drug Administration (FDA). − While the most applied technique for nanofibrous mats for biomedical applications is electrospinning, the literature highlights the advantages of SBS due to its higher production yield, facilitating the large-scale production.…”