Development and Characterization of Curcumin Loaded Silver Nanoparticle Hydrogels for Antibacterial and Drug Delivery Applications

Ravindra, S.; Mulaba‐Bafubiandi, Antoine F.; Rajinikanth, V.; Varaprasad, Kokkarachedu; Reddy, Narendra; Raju, K. Mohana

doi:10.1007/s10904-012-9734-4

Cited by 65 publications

(26 citation statements)

References 25 publications

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“…Ag NPs-curcumin hydrogels for wound dressing were also reported, exhibiting good antibacterial properties and sustained release, which indicate enormous prolonged therapeutic value. 213,214 A polysaccharide extracted from Aloe vera, Acemannan, has various medical properties, such as antibacterial property, and it can accelerate healing of lesions. 215 Some studies demonstrated its antibacterial activity against both susceptible and resistant H. pylori strains.…”

Section: Biological Extractsmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

302

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Section: Biological Extractsmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

302

230

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“…The swelling behavior of hydrophilic hydrogel samples were measured at room temperature, using a swelling method . The completely dried hydrogels were immersed in a 100 mL beaker containing twice distilled water until their weight became constant (24 h).…”

Section: Methodsmentioning

confidence: 99%

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

Varaprasad¹,

Sadiku

2015

J of Applied Polymer Sci

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In this scientific work, a novel class of antimicrobial nanocomposite hydrogels were designed and synthesized by chemical and environmentally bioprocess using Kolliphor, acrylamide, and mint leafs in order to achieve antiseptic property for wound applications. In the bioprocess approach, silver nitrate and gold chloride were nucleated with mint leafs in order to obtain effective free individual nano-inorganic compounds to provide superior antibacterial assets. The formations of dual inorganic nanoparticles were confirmed by transmission electron microscopy, which indicated the size of nanoparticles in the range of approximately 3 6 2 nm and without agglomeration. The formations of biomaterials were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopic-energy dispersive spectrometric studies and their swelling properties were determined. Furthermore, the pure hydrogel and the dual inorganic nanocomposite hydrogels developed were tested for antibacterial activities. When compared with the neat hydrogel, the nanocomposite hydrogels significantly improved their anti-bacterial activities on Bacillus bacterium.

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“…The band at 1202/cm represented the C-N stretching vibration of hydrogel units. The absorption band at 1036.4/cm is due to the vibrational stretching of the -SO3H group of SA-PA-LSA unit [44,45].…”

Section: Uv/visible (Uv-vis) Spectroscopymentioning

confidence: 99%

Synthesis and Characterization of Novel Sa-Pa-Lsa/C-30b/Ag Nanocomposites for Swelling, Antibacterial, Drug Delivery, and Anticancer Applications

Rauta

Venkatalakshimi³

et al. 2018

Asian J Pharm Clin Res

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Objective: The main objective of this work was to formulate and evaluate Closite-30B/nanoAg filled hydrogel composites which are further intentended to be used for the study of drug delivery,antibacterial, and anticancer activityMethods: In this study, Cloisite-30B (C-30B) clay dispersed biopolymer sodium alginate (SA)-grafted-poly (acrylamide [AAm]-co-lignosulfonic acid) hydrogel composites were synthesized by free radical in situ polymerization reaction technique using SA, AAm, and lignosulfonic acid biopolymers in different proportions in combination. which are subjected to invitro drug delivery and Minimum inhibitory concentration(MIC) method for antibacterial activity study by using Streptococcus faecalis (S.faecalis) and Escherichia coli (E. coli)bacteria. The biocompatibility of the prepared gels were determined by standard protocol HaCaT-cells and MCF-7 cell lines further the prepared hydrogel composites were characterized for particle size,encapsulation efficiency,swelling properties,compatibility studies by FTIR etc.Results: The formulated hydrogels were characterized by X-ray diffraction (XRD) to analyze the particles size and crystallinity. The presence of functional groups and their chemical interaction with the drug, C-30B, and silver nanoparticles (AgNPs) were confirmed by the FTIR spectroscopy. Furthermore, the presence of AgNPs in the matrix was confirmed by ultraviolet/visible spectroscopy. Thermogravimetric analysis was performed to find out the thermal degradation, thermal stability, and the percentage of weight loss at various temperatures. Swelling studies revealed that C-30B and AgNPs induced composites exhibited higher swelling ratio than pure hydrogels. The hydrogels with C-30B/AgNPs displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria. Further, these hydrogel composites were loaded with the drug paclitaxel (PT), and drug release study showed that the sustained release of the drug from C-30B/Ag hydrogel matrix compared to rest of other samples. Hydrogel composites were cytocompatible in nature (with HaCaT cells) and the cell viability decreased (with MCF-7cells) with the presence of lignosulfonic acid as well as C-30B and AgNPs in the samples as evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide to its insoluble formazan assay.Conclusion: The synthesized hydrogel composites were successfully characterized and eavaluated for sustained release of paclitaxel drug delivery at different pHs and temperatures and it is found that C30B/Ag filled composites exhibits contolled release of drug with higher rate, especially at lower pH (pH2) and higher temperature (37oC) and the same formulations which exhibits better anitbcterial and anticancer activity compared to the virgin samples So the prepared C30B/AgNPs hydrogels composites used in drug dlivery for the effective treatment of cancer and used against bacterias and cancerous cells.

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Development and Characterization of Curcumin Loaded Silver Nanoparticle Hydrogels for Antibacterial and Drug Delivery Applications

Cited by 65 publications

References 25 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

Synthesis and Characterization of Novel Sa-Pa-Lsa/C-30b/Ag Nanocomposites for Swelling, Antibacterial, Drug Delivery, and Anticancer Applications

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