Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration

Nagiah, Naveen; Madhavi, Lakshmi; Anitha, R.; Anandan, C.; Srinivasan, Natarajan Tirupattur; Sivagnanam, Uma Tirichurapalli

doi:10.1016/j.msec.2013.06.042

Cited by 60 publications

(82 citation statements)

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“…In this case, the goal was to combine these two biocompatible and biodegradable polymers, thus creating a new material with potential biomedical application. Another example is the PHB (core) and gelatin (sheath) coaxial electrospinning, producing porous fibrous mats with potential as a scaffold (dermal substitute) for skin regeneration 7 . The present work, thus, aims to show the possible PHB properties changes, mainly in the crystallinity, when this biopolymer was processed through thermo compression molding or electrospinning.…”

Section: Introductionmentioning

confidence: 99%

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

et al. 2016

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Section: Introductionmentioning

confidence: 99%

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

et al. 2016

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“…Coaxially electrospun fibers in comparison with coated or blended fibers have shown enhanced biocompatible and mechanical properties for tissue engineering and regenerative applications. 11,12 Few attempts have been made using coaxial electrospinning to develop small diameter artery grafts. 13–17 In coaxial electrospinning, two compartments containing either different polymer solutions or a mixture of a polymer solution for the formation of shell and a nonpolymeric Newtonian liquid or even a powder for the formation of core are used to initiate a core–shell jet.…”

Section: Introductionmentioning

confidence: 99%

Highly Compliant Vascular Grafts with Gelatin-Sheathed Coaxially Structured Nanofibers

et al. 2015

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We have developed three types of materials composed of polyurethane–gelatin, polycaprolactone–gelatin, or polylactic acid–gelatin nanofibers by coaxially electro-spinning the hydrophobic core and gelatin sheath with a ratio of 1:5 at fixed concentrations. Results from attenuated total reflection-Fourier transformed infrared spectroscopy demonstrated the gelatin coating around nanofibers in all of the materials. Transmission electron microscopy images further displayed the core–sheath structures showing the core-to-sheath thickness ratio varied greatly with the highest ratio found in polyurethane-gelatin nanofibers. Scanning electron microscopy images revealed similar, uniform fibrous structures in all of the materials, which changed with genipin cross-linking due to interfiber interactions. Thermal analyses revealed varied interactions between the hydrophilic sheath and hydrophobic core among the three materials, which likely caused different core–sheath structures, and thus physicomechanical properties. The addition of gelatin around the hydrophobic polymer and their interactions led to the formation of graft scaffolds with tissue-like viscoelasticity, high compliance, excellent swelling capability, and absence of water permeability while maintaining competent tensile modulus, burst pressure, and suture retention. The hydrogel-like characteristics are advantageous for vascular grafting use, because of the capability of bypassing preclotting prior to implantation, retaining vascular fluid volume, and facilitating molecular transport across the graft wall, as shown by coculturing vascular cells sandwiched over a thick-wall scaffold. Varied core–sheath interactions within scaffolding nanofibers led to differences in graft functional properties such as water swelling ratio, compliance, and supporting growth of cocultured vascular cells. The PCL–gelatin scaffold with thick gelatin-sheathed nanofibers demonstrated a more compliant structure, elastic mechanics, and high water swelling property. Our results demonstrate a feasible approach to produce new hybrid, biodegradable nanofibrous scaffold biomaterials with interactive core–sheath structure, good biocompatibility, and tissue-like viscoelasticity, which may reduce potential problems with the use of individual polymers for vascular grafts.

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“…Several approaches have been explored, including alkali hydrolysis treatment, surface modification plasma processes, ion irradiation, and conventional coatings, to improve the bioactivity of biomaterials with N‐ and O‐containing surface groups on scaffolds. Among others, wet approaches like hydrolysis, aminolysis, and oxidation/etching are generally characterized by low versatility and irregular and excessive surface roughness, as they depend on molecular weight, crystallinity, and tacticity of the polymer .…”

Section: Introductionmentioning

confidence: 99%

N₂/H₂o Plasma Assisted Functionalization of Poly(ε‐caprolactone) Porous Scaffolds: Acidic/Basic Character versus Cell Behavior

Sardella

Fisher

Shearer

et al. 2015

Plasma Processes & Polymers

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A primary research focus in tissue engineering addresses the factors that drive cell growth in scaffolds. Due to the inherent complexity of phenomena at the cell/biomaterial interface in cell‐culture media, it is not easy to unambiguously disentangle the effects of different surface properties (e.g., chemical composition, roughness, porosity, etc.) in promoting specific cell behaviors, especially on porous scaffold materials. We have investigated fast low‐pressure plasma treatments of porous PCL scaffolds for tissue engineering with neutral, acidic, and basic groups to obtain stable water absorbent materials. An increase of Saos2 cell growth was observed on plasma‐treated scaffolds with respect to native samples; amphoteric surfaces were found very suitable for cell proliferation.

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Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration

Cited by 60 publications

References 26 publications

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

Highly Compliant Vascular Grafts with Gelatin-Sheathed Coaxially Structured Nanofibers

N₂/H₂o Plasma Assisted Functionalization of Poly(ε‐caprolactone) Porous Scaffolds: Acidic/Basic Character versus Cell Behavior

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Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration

Cited by 60 publications

References 26 publications

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

Highly Compliant Vascular Grafts with Gelatin-Sheathed Coaxially Structured Nanofibers

N2/H2o Plasma Assisted Functionalization of Poly(ε‐caprolactone) Porous Scaffolds: Acidic/Basic Character versus Cell Behavior

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N₂/H₂o Plasma Assisted Functionalization of Poly(ε‐caprolactone) Porous Scaffolds: Acidic/Basic Character versus Cell Behavior