Development and characterization of antitumoral electrospun polycaprolactone/functionalized Fe3O4 hybrid membranes

Guadagno, Liberata; Raimondo, Marialuigia; Longo, Raffaele; Sarno, Maria; Iuliano, Mariagrazia; Mariconda, Annaluisa; Saturnino, Carmela; Ceramella, Jessica; Iacopetta, Domenico; Sinicropi, Maria Stefania

doi:10.1016/j.mtchem.2020.100309

Cited by 22 publications

(27 citation statements)

References 36 publications

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“…In fact, McKeon-Fischer et al [ 162 ] also highlighted the lack of toxicity of the Au-NP/matrix system, which was used as a scaffold for the healing process of the skeletal muscle. For cancer treatment, Guadagno et al [ 164 ] proved that the use of PCL membranes loaded with functionalized magnetite NPs (PCL-Fe 3 O 4 ) was particularly effective for the treatment of melanomas and for uterine cervix cancer even with no drug and no hyperthermia-induced treatment. In evaluating the viability of the cells, the results showed that for HeLa cells, the maximum abatement of the cell viability was reported for the system combined of PCL-Fe 3 O 4 , with almost a 35% cell viability recorded at the end of the treatment.…”

Section: Transdermal Delivery Systems Stimuli-responsivementioning

confidence: 99%

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

2021

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Nanoparticles (NPs) in the biomedical field are known for many decades as carriers for drugs that are used to overcome biological barriers and reduce drug doses to be administrated. Some types of NPs can interact with external stimuli, such as electromagnetic radiations, promoting interesting effects (e.g., hyperthermia) or even modifying the interactions between electromagnetic field and the biological system (e.g., electroporation). For these reasons, at present these nanomaterial applications are intensively studied, especially for drugs that manifest relevant side effects, for which it is necessary to find alternatives in order to reduce the effective dose. In this review, the main electromagnetic-induced effects are deeply analyzed, with a particular focus on the activation of hyperthermia and electroporation phenomena, showing the enhanced biological performance resulting from an engineered/tailored design of the nanoparticle characteristics. Moreover, the possibility of integrating these nanofillers in polymeric matrices (e.g., electrospun membranes) is described and discussed in light of promising applications resulting from new transdermal drug delivery systems with controllable morphology and release kinetics controlled by a suitable stimulation of the interacting systems (nanofiller and interacting cells).

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Section: Transdermal Delivery Systems Stimuli-responsivementioning

confidence: 99%

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

2021

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“…Data are expressed as bacterial viability (BV) (%). BV = (PPD − IDs)/PPD × 100 (2) where 100% BV represents the bacteria viability without samples. The mean standard deviation is expressed as a relative standard deviation (RSD).…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Iron is an important metal for human life because it is a cofactor of many types of enzymes and cytochromes of the mitochondrial electron transport chain, and it is part of the haemoglobin and myoglobin structures, which act as oxygen transporters. The use of ferrous organic complexes, such as iron (II) citrate, represents an excellent option to improve health care, since they increase bioavailability and solubility, solving the iron deficiency problem [1][2][3][4]. At the physiological pH of blood (7.4), high levels of Fe 2+ (aq) would theoretically result in the precipitation of iron (II) hydroxide.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route

et al. 2021

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The aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO2/Fe20 wt% to modulate the release kinetics of the drug from the systems. Fourier-transform infrared (FTIR) spectroscopy was used to study the interactions between different components in the hybrid materials. The release kinetics in a simulated body fluid (SBF) were investigated, and the amount of Fe2+ released was detected via ultraviolet-visible spectroscopy (UV-Vis) after reaction with ortho-phenanthroline. Furthermore, biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated via the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using spectroscopy. Finally, the potential antibacterial properties of seven different materials against two different bacteria—E. coli and S. aureus—were investigated.

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“…Of great interest to most researchers dealing with nanotechnology science are nanoparticles due to the fact that the most of the research works reported in the literature have focused to interconnect the engineered science of these nanomaterials with medical problems. Nanoparticles are broadly used in all areas of medicine from drug development [5][6][7] to magnetic resonance imaging and hyperthermia for the treatment of cancer [8][9][10][11], targeted drug delivery [12,13], computer tomograf (CT) and optical imaging [14,15], cellular therapy [16,17], tissue repair [18], and gene manipulations [19,20].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Fe3O4@Carbon Nanoparticles and Their Biological Screening Related to Oral Administration

et al. 2021

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The current study presents the effect of naked Fe3O4@Carbon nanoparticles obtained by the combustion method on primary human gingival fibroblasts (HGFs) and primary gingival keratinocytes (PGKs)—relevant cell lines of buccal oral mucosa. In this regard, the objectives of this study were as follows: (i) development via combustion method and characterization of nanosized magnetite particles with carbon on their surface, (ii) biocompatibility assessment of the obtained magnetic nanoparticles on HGF and PGK cell lines and (iii) evaluation of possible irritative reaction of Fe3O4@Carbon nanoparticles on the highly vascularized chorioallantoic membrane of a chick embryo. Physicochemical properties of Fe3O4@Carbon nanoparticles were characterized in terms of phase composition, chemical structure, and polymorphic and molecular interactions of the chemical bonds within the nanomaterial, magnetic measurements, ultrastructure, morphology, and elemental composition. The X-ray diffraction analysis revealed the formation of magnetite as phase pure without any other secondary phases, and Raman spectroscopy exhibit that the pre-formed magnetic nanoparticles were covered with carbon film, resulting from the synthesis method employed. Scanning electron microscopy shown that nanoparticles obtained were uniformly distributed, with a nearly spherical shape with sizes at the nanometric level; iron, oxygen, and carbon were the only elements detected. While biological screening of Fe3O4@Carbon nanoparticles revealed no significant cytotoxic potential on the HGF and PGK cell lines, a slight sign of irritation was observed on a limited area on the chorioallantoic membrane of the chick embryo.

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Development and characterization of antitumoral electrospun polycaprolactone/functionalized Fe3O4 hybrid membranes

Cited by 22 publications

References 36 publications

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route

Development and Characterization of Fe3O4@Carbon Nanoparticles and Their Biological Screening Related to Oral Administration

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