Development and characterization of a novel porous β-TCP scaffold with a three-dimensional PLLA network structure for use in bone tissue engineering

Customized hybrid biomimetic hydroxyapatite scaffold for bone tissue regeneration

“…[21][22][23][24] The limit of these materials is due to their mechanical properties being far from those of natural bone. Biocompatible polymers relatively allowed to overcome these limitations, [25][26][27] for example polymer2ceramic composites 28 that mimick the ductile and brittle properties of natural bone, 29 but their use involves problems in terms of poor integration with the biological environment and mechanical mismatch. 30 Moreover, although many bone substitutes are biologically degraded with nontoxic byproducts formation, the degradation rate has to be as close as possible to the physiological bone resorption rate, since a too fast degradation would result in a premature collapse of the scaffold before the tissue has been regenerated 31 ; degradation must take place contemporarily to new bone formation in order to allow a natural bone regeneration without leaving any remnant.…”

Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

“…Therefore, as an interdisciplinary field, tissue engineering concerns the development of biological substitutes capable of replacing or repairing diseased or damaged tissue and organs in humans [1][2][3][4] . Since the 80's, and especially in the last decade, tissue engineering and regenerative medicine have been proving its importance and potential to revolutionize important areas of medicine [1][2][3][4] , such as cardiovascular [5][6] , skin regeneration 7 and bone treatments [8][9][10][11] . Replacement tissues can be produced by first seeding human cells onto scaffolds [1][2][3][4] .…”

“…Some common properties of an ideal scaffold for tissue engineering are biocompatibility, porosity with interconnected pores and adequate mechanical strength, depending mainly on the tissue to be repaired [1][2]4,[10][11] . An ideal scaffold porosity is required to maximize the space for cellular adhesion, growth, revascularization, adequate nutrition and other factors that can influence cellular and tissue growth [1][2][3][4][9][10] . Different methods have been studied and improved in the past years to obtain scaffolds with desired properties 1,10 , such as porogen particles 12 , emulsion [13][14][15] , replication 8,16 , gel-casting of foams 12,14,[16][17][18] and additive manufacture 19 .…”

“…Bone scaffolds can have an optimal performance so long as they can be bio-degradable, bio-resorbable and capable of providing mechanical support for repair and regeneration of diseased or damaged bone while the growing tissue replaces the scaffold [1][2][3][4][9][10] . There are many ceramic materials that have been used for bone tissue engineering, such as calcium phosphates, especially hydroxyapatite (HA) 1,12,16,18 and β-tricalcium phosphate (β-TCP) 1,8,16 , bioactive glass 24,25 and titania 26 .…”

Peculiarities of formation of sintered electrodes of the Ti–Ti3P–CaO composition and their application in technology of pulsed electric-discharge machining of titanium

“…Биоматериалы на основе фосфата кальция Ca 3 (PO 4 ) 2 представляют особый интерес в эндо-протезирующей хирургии и находят применение в восстановлении или замене участков повреж-денной костной ткани [1][2][3]. Ca 3 (PO 4 ) 2 широко используется в качестве биоактивной границы раздела между поверхностью металлического им-плантата и окружающей тканью благодаря бли-зости химического состава (особенно по соотно-шению числа атомов Ca/P [4,5]) с компонентами зубной и костной тканей.…”