Development and characterisation of glucosamine sulphate magnetic nanoparticles for rheumatoid arthritis chemotherapy

Latha, S.; Selvamani, P.; Raj, Deepak

doi:10.1049/mnl.2019.0748

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Of great interest to most researchers dealing with nanotechnology science are nanoparticles due to the fact that the most of the research works reported in the literature have focused to interconnect the engineered science of these nanomaterials with medical problems. Nanoparticles are broadly used in all areas of medicine from drug development [5][6][7] to magnetic resonance imaging and hyperthermia for the treatment of cancer [8][9][10][11], targeted drug delivery [12,13], computer tomograf (CT) and optical imaging [14,15], cellular therapy [16,17], tissue repair [18], and gene manipulations [19,20].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Fe3O4@Carbon Nanoparticles and Their Biological Screening Related to Oral Administration

et al. 2021

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The current study presents the effect of naked Fe3O4@Carbon nanoparticles obtained by the combustion method on primary human gingival fibroblasts (HGFs) and primary gingival keratinocytes (PGKs)—relevant cell lines of buccal oral mucosa. In this regard, the objectives of this study were as follows: (i) development via combustion method and characterization of nanosized magnetite particles with carbon on their surface, (ii) biocompatibility assessment of the obtained magnetic nanoparticles on HGF and PGK cell lines and (iii) evaluation of possible irritative reaction of Fe3O4@Carbon nanoparticles on the highly vascularized chorioallantoic membrane of a chick embryo. Physicochemical properties of Fe3O4@Carbon nanoparticles were characterized in terms of phase composition, chemical structure, and polymorphic and molecular interactions of the chemical bonds within the nanomaterial, magnetic measurements, ultrastructure, morphology, and elemental composition. The X-ray diffraction analysis revealed the formation of magnetite as phase pure without any other secondary phases, and Raman spectroscopy exhibit that the pre-formed magnetic nanoparticles were covered with carbon film, resulting from the synthesis method employed. Scanning electron microscopy shown that nanoparticles obtained were uniformly distributed, with a nearly spherical shape with sizes at the nanometric level; iron, oxygen, and carbon were the only elements detected. While biological screening of Fe3O4@Carbon nanoparticles revealed no significant cytotoxic potential on the HGF and PGK cell lines, a slight sign of irritation was observed on a limited area on the chorioallantoic membrane of the chick embryo.

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