Preparation and In-vitro Evaluation of Pantoprazole Sodium Magnetic Microspheres by Emulsion Solvent Evaporation Method

Latha, S.; Selvamani, P. Stephen; Suganya, G.; Raj, Deepak; Pal, Tapan Kumar

doi:10.1007/s12668-021-00837-2

Cited by 4 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These two types of polymers (ERL and ERS), with different permeabilities, are often used together in different proportions to achieve the target specific permeability and the desired rate of intestinal absorption. These polymers, alone or in blends, have been used in pharmaceutics for the development of micro [39,40] and nanoparticles [41][42][43][44], coated tablets [45] and mucoadhesive buccal films [46], among others, mainly to obtain sustained release delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

View full text Add to dashboard Cite

Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The preparation methods of sustained-release microspheres mainly include the emulsification-solvent evaporation method (Mcginity & O’donnell, 1997 , Latha et al., 2021 ), spray drying method (Giunchedi et al., 2001 , Wang et al., 2008 ), phase separation method (Fu et al., 2012 ), membrane emulsification method (Wang et al., 2005 ), microfluidic method (Wang et al., 2018 ), and hot-melt extrusion method (Guo et al., 2017 ). The emulsification-solvent evaporation method is the most widely used preparation method in the marketed microsphere products.…”

Section: Introductionmentioning

confidence: 99%

Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency

Guo

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

The purpose of this study was to prepare GeXIVA[1,2] PLGA microspheres by W/O/W re-emulsification-solvent evaporation technology and to develop sustained-release formulations to meet the clinical treatment needs of chronic neuropathic pain. Through prescription optimization, the uniformity of particle size and the encapsulation efficiency is improved, so as to achieve the quality standard of the microspheres. The mechanism of trehalose improving the stability of GeXIVA[1,2] was studied and verified by molecular simulation. The results showed that when adding trehalose to W1, using the PLGA model of 75:25, PLGA concentration of 30%, PVA concentration of 1.5%, adding 1% NaCl to PVA and adding 1% NaCl to solidification water, the prepared microspheres are smooth, the particle size is about 25 μm, and the encapsulation rate reaches 90%. The results of in vitro release experiments showed that the microspheres could be released steadily for about 30 days. The microsphere samples were characterized and analyzed by molecular simulation and powder X-ray diffractometer, and the protective mechanism of trehalose on GeXIVA[1,2] was discussed. The results showed that the hydrogen bond formed between trehalose and GeXIVA[1,2] acted as a hydration film and played a certain protective role on GeXIVA[1,2]. In addition, high-viscosity trehalose can form a glass state and wrap around GeXIVA[1,2], reducing the free movement of molecules. In the microsphere system, trehalose can also avoid the influence of PLGA material on the secondary structure of GeXIVA[1,2]. In conclusion, this study is expected to provide a new therapeutic strategy for the treatment of chronic neuropathic pain.

show abstract

Sustained release of resveratrol from fused deposition modelling guided 3D porous scaffold for bone tissue engineering

Sri

Ganapathy

Nallasamy

et al. 2023

Process Biochemistry

View full text Add to dashboard Cite

Preparation and In-vitro Evaluation of Pantoprazole Sodium Magnetic Microspheres by Emulsion Solvent Evaporation Method

Cited by 4 publications

References 12 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency

Sustained release of resveratrol from fused deposition modelling guided 3D porous scaffold for bone tissue engineering

Contact Info

Product

Resources

About