Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery

Martinac, Anita; Filipović-Grčić, Jelena; Voinovich, Dario; Perissutti, Beatrice; Franceschinis, Erica

doi:10.1016/j.ijpharm.2004.07.044

Cited by 108 publications

(40 citation statements)

References 13 publications

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“…Even that given production yield results seemed to limited, there are studies in the literature that showed similar values (Giunchedi et al, 2002;Martinac et al, 2005;Gavini et al, 2006). The lower yields could be explained by aspiration of the small microspheres and attached polymer droplets in the spraying wall of the spray-dryer, as also reported by Giunchedi et al (2002) and Gavini et al (2006).…”

Section: Preparation Of Microspheres and Percent Yield Valuementioning

confidence: 63%

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

et al. 2010

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Section: Preparation Of Microspheres and Percent Yield Valuementioning

confidence: 63%

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

et al. 2010

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“…The statistical analyses were realized by Student's t-test (independent samples) with p<0.05 as the minimal level of significance (Martinac et al, 2005). Data were analyzed in Microsoft Office Excel 2007.…”

Section: Discussionmentioning

confidence: 99%

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

Nohemann

Almeida

Ferrari

2017

Braz. J. Pharm. Sci.

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Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the presence of some crystalline peaks of metronidazole in microparticles. All microparticles floated immediately in contact of simulated gastric fluid and both floating and drug release profiles were dependent of microparticles composition. Microparticles samples constituted by chitosan and hydroxypropyl methylcellulose revealed the best relationship between floating duration and drug release, remaining floating during the occurrence of the drug release, ideal condition for the floating gastroretentive systems.Uniterms: Floating microparticle. Chitosan. Ethylcellulose. Hydroxypropyl methylcellulose. Controlled drug delivery.

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“…A mass of formulation (0.25 g) appropriate for the nasal cavity volume was transferred to a glass vial and allowed to equilibrate in a dry block at 34 °C. Artificial nasal electrolyte (ANE) (0.8 g/L NaCl, 3 g/L KCl, and 0.45 g/L CaCl2, pH 6.8) 44 was used as release media and 100 µL transferred onto the gelled formulation. This volume was completely withdraw and replaced with fresh ANE at each time point.…”

Section: Stability Assessmentmentioning

confidence: 99%

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

Lungare

Bowen

Badhan

2016

Journal of Pharmaceutical Sciences

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The aim of this study was to develop and characterise an intranasal delivery system for amantadine (AMT). Optimal formulations (F) consisted of a thermosensitive polymer Pluronic ® 127 (P127) and either carboxy methyl cellulose (CMC) or chitosan (CS) which demonstrated gel-transition at nasal cavity temperatures (34 °C ± 1 °C). Rheologically, the loss tangent (Tan δ) confirmed a three-stage gelation phenomena at 34 °C ± 1 °C and nonNewtonian behaviour. Storage of FCMC and FCS at 4 °C for 8 weeks resulted in repeatable release profiles at 34 °C when sampled, with a Fickian mechanism earlier on but moving towards anomalous transport by week 8. Polymers (P127, CMC and CS) demonstrated no significant cellular toxicity to human nasal epithelial cells up to 4 mg/mL and up to 1 mM for AMT (IC50: 4.5 mM ± 0.05 mM). FCMC and FCS demonstrated slower release across an in-vitro human nasal airway model (43-44 % vs 79 % ± 4.58 % for AMT). Using a human nasal cast model, deposition into the olfactory regions (potential nose-to-brain) was demonstrated upon nozzle insertion (5 mm) whereas tilting of the head forward (15°) resulted in greater deposition in the bulk of the nasal cavity. KEYWORDSParkinson's disease; rheology; nasal; RPMI 2650; nose to brain; thermoresponsive; 3 INTRODUCTION Parkinson's disease (PD) is an ageing associated progressive neurological disorder and affects 1.5 % of the population over 65-years of age 1 , with age-adjusted prevalence rates thought to be around 150 per 100,000 with a suggested mean onset in the 70's 1 . Ageing is the largest single risk factor for the development of PD and the pathogenesis of PD is composed of a range of events leading towards neuronal apoptosis, primarily of degradation of dopamine neurones in the sustantia nigra. The mainstay of clinical drug therapy focuses on increases the levels of dopamine (DA) in the brain, with oral dosing of levodopa being the most commonly used to pharmacological intervention treatment to reverse the symptoms of PD. It is also common to use adjunct therapies in conjunction with levodopa, such as the weak NMDA-type receptor antagonist amantadine, which can aid in blocking dopamine reuptake.

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Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery

Cited by 108 publications

References 13 publications

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

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Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery

Cited by 108 publications

References 13 publications

Optimization of prednisolone acetate-loaded chitosan microspheres using a 23factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 23factorial design for preventing restenosis

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

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Product

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Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis