Development and Application of Electrochemical Sensor Based on Molecularly Imprinted Polymer and Carbon Nanotubes for the Determination of Carvedilol

Abstract

This work describes the preparation of a glassy carbon electrode (GCE) modified with molecularly imprinted polymer (MIP) and multiwalled carbon nanotubes (MWCNTs) for determination of carvedilol (CAR). Electrochemical behavior of CAR on the modified electrode was evaluated using cyclic voltammetry. The best composition was found to be 65% (m/m) of MIP. Under optimized conditions (pH 8.5 in 0.25 mol·L −1 Britton-Robinson buffer and 0.1 mol·L −1 KCl) the voltammetric method showed a linear response for CAR in the range of 50-325 µmol·L −1 (R = 0.9755), with detection and quantification limits of 16.14 µmol·L −1 and 53.8 µmol·L −1 , respectively. The developed method was successfully applied for determination of CAR in real samples of pharmaceuticals. The sensor presented good sensitivity, rapid detection of CAR, and quick and easy preparation. Furthermore, the material used as modifier has a simple synthesis and its amount utilized is very small, thus illustrating the economic feasibility of this sensor.

Electrochemical sensor based on nanostructured ion imprinted polymer for the sensing and extraction of Cr(III) ions from industrial wastewater

“…About 1.0 mg of Cr(III) ion imprinted MWCNT‐IIP was added to 1 mL of 0.5% Nafion solution and homogenized in a mortar for 10 min. Nafion solution was used in this study for the fixation of imprinted polymer to the platinum electrode surface . The final paste was fabricated on the platinum electrode surface and allowed to dry at room temperature; it is designated Pt‐MWCNT‐IIP.…”

“…Nafion solution was used in this study for the fixation of imprinted polymer to the platinum electrode surface. 14,15 The final paste was fabricated on the platinum electrode surface and allowed to dry at room temperature; it is designated Pt-MWCNT-IIP. Phosphate buffer was used in this study to supply conductivity for the paste fabricated on the platinum electrode.…”

Smart Polymers in Micro and Nano Sensory Devices

“…(For additional information, please see references [141,144,145,148,150,151,156,160]). [183][184][185] Quartz Crystal Microbalances Piezoelectric [14,114,130,146,[186][187][188][189][190][191][192] Microfluidic devices Optical [27,128,150,[193][194][195]] Electrical [148,190] Modified electrodes Electrochemical [26,99,[152][153][154][155][196][197][198][199][200][201][202] Sensory chips Optical [161,[193][194][195] Table 2. Cont.…”

An electrochemical sensor and sorbent based on mutiwalled carbon nanotube supported ion imprinting technique for Ni(II) ion from electroplating and steel industries

“…Nafion is a polymeric resin with properties like chemical and thermal stability and has high selectivity towards different cations. Nafion is used in this study for the fixation of imprinted polymer on to the platinum electrode surface [18][19][20]. The mixture was carefully coated on the platinum electrode surface and dried at room temperature [21,22].…”