Development and application of a model (ExDoM) for calculating the respiratory tract dose and retention of particles under variable exposure conditions

Aleksandropoulou, V.; Lazaridis, Mihalis

doi:10.1007/s11869-010-0126-z

Cited by 41 publications

(38 citation statements)

References 49 publications

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“…An exposure and dose assessment model for simulating the dynamics of respirable particulate matter in human airways was developed by Aleksandropoulou and Lazaridis (2013). The estimation of the human dose is based on the Human Respiratory Tract Model (HRTM) of the ICRP (ICRP, 1994a).…”

Section: Exposure and Dose Assessment Using The Exdom Modelmentioning

confidence: 99%

“…In the ET1 region no absorption to the blood occurs (ICRP, 1994a).A detailed description of the ExDoM can be found in Aleksandropoulou and Lazaridis (2013) The output (lung dose, blood dose and GI_tract dose) from the ExDoM model was used as input for PBPK model.…”

Section: Exposure and Dose Assessment Using The Exdom Modelmentioning

confidence: 99%

“…Regarding GI tract the highest dose receives a citizen of Frankfurt 1.26 × 10 2 µg, with Rome (1.15 × 10 2 µg), Seville (1.11 × 10 2 µg), Zabrze (8.98 × 10 1 µg) and Athens (6.93 × 10 1 µg) following. The deposition in the GI tract is related with the ambient concentration of coarse particles (Table 2) because coarse particles are mainly deposited in the upper respiratory tract regions and transferred to the trachea by the mucociliary escalator and swallowed to the GI tract (Aleksandropoulou and Lazaridis, 2013).The greater the percentage of coarse particles the greater the transport of particles from the respiratory tract to GI tract and more specifically the percentage of particles transported to the GI tract correspond to: 61% in Rome; 59% in Athens; 57% in Frankfurt; 44% in Zabrze and 42% in Seville.…”

Section: Calculation Of the Dose Of Particulate Matter-bound Metals Umentioning

confidence: 99%

“…The exposure model Exposure Dose Model (ExDoM; Aleksandropoulou and Lazaridis, 2013) is used for the estimation of the deposited dose and retention of aerosol particles-bound metals (Pb, Cd, As) in the respiratory tract (RT) of human body and a pharmacokinetic PBPK model (Chalvatzaki et al, 2014;Chalvatzaki et al, 2015) is also applied to estimate the movement of metals from the blood into the tissues as a blood-flow-limited model.…”

Section: Introductionmentioning

confidence: 99%

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Personal Exposure and Dose of Inhaled Ambient Particulate Matter Bound Metals in Five European Cities

Mammi-Galani

Chalvatzaki

Lazaridis

2016

Aerosol Air Qual. Res.

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The objective of the current study is the determination of the personal exposure and dose of ambient particulate matterbound metals in human tissues at five European cities. The accumulation in human body of lead (Pb), arsenic (As) and cadmium (Cd), in five European cities (Athens, Seville, Rome, Frankfurt and Zabrze) was calculated using an exposure and dose assessment model, ExDoM, and a pharmacokinetic model, PBPK. The study subjects are adult Caucasian nonsmoker males. It was calculated that the highest dose of particulate matter is received from a resident of Seville, due to the higher ambient PM 10 levels in the city compared to the other sites. First, the current study showed that the European Union thresholds of particle-bound Pb, Cd and As concentrations were not exceeded in the cities under study. As regard the dose of Pb and As the higher dose is calculated for Athens and Seville, respectively. The highest dose of Cd is found at Zabrze, due to the high industrial activity in the city. It was calculated that after one day of exposure, the highest accumulation of Pb occurred in blood, muscles and bones. Furthermore, the highest deposition of Cd occurred in the lungs and intestines and for As in the lung and muscles. The heavy metals intake, calculated in this study, was very low in comparison with the recommended WHO levels for heavy metals intake from all types of exposure (inhalation, ingestion).

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Section: Exposure and Dose Assessment Using The Exdom Modelmentioning

confidence: 99%

Section: Exposure and Dose Assessment Using The Exdom Modelmentioning

confidence: 99%

Section: Calculation Of the Dose Of Particulate Matter-bound Metals Umentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Personal Exposure and Dose of Inhaled Ambient Particulate Matter Bound Metals in Five European Cities

Mammi-Galani

Chalvatzaki

Lazaridis

2016

Aerosol Air Qual. Res.

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“…Additionally, a mass balance model was adapted in order to estimate the emission rates of particles sources within the investigated indoor environment. Furthermore, the Exposure Dose Model (ExDoM; Aleksandropoulou and Lazaridis, 2013) is used for the estimation of the deposited dose and retention of aerosol particles in the respiratory tract (RT) of adult workers at the site of manual waste sorting.…”

Section: Introductionmentioning

confidence: 99%

Particulate matter characterization in an indoor workplace environment of a landfill

2015

Issue 2

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The current study focus on the quantification of the particulate matter (PM10) concentrations at the workplace environment of a manual waste sorting of a landfill using portable real-time photometric monitors. Increased PM10 mass concentrations were measured during the process of manual sorting of waste. It is observed that the daily average PM10 concentration on working days was equal to 149 μg m -3 while the corresponding daily PM10 concentration on non-working days was equal to 42 μg m . An indoor mass balance model was applied to estimate the PM10 mass emission rates, as well as the particle loss rates due to all removal processes. A good agreement was obtained between the model predictions and the measurements. In addition, the PM10 field measurements were further analysed with the ExDoM (Exposure Dose Model) human dosimetry model which used for calculating the human exposure and the deposition dose, clearance, and finally retention of particles in the human respiratory tract (RT).

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Environmental Toxicology of Nanomaterials: Advances and Challenges

Utembe

2022

Nanotechnology for Environmental Remediation

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Development and application of a model (ExDoM) for calculating the respiratory tract dose and retention of particles under variable exposure conditions

Cited by 41 publications

References 49 publications

Personal Exposure and Dose of Inhaled Ambient Particulate Matter Bound Metals in Five European Cities

Personal Exposure and Dose of Inhaled Ambient Particulate Matter Bound Metals in Five European Cities

Particulate matter characterization in an indoor workplace environment of a landfill

Environmental Toxicology of Nanomaterials: Advances and Challenges

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