The objective of the current study was to estimate health risk indexes caused by the inhalation of particulate matter (PM) by adult males and children using data sampled in three European cities (Athens, Kuopio, Lisbon). Accordingly, the cancer risk (CR) and the hazard quotient (HQ) were estimated from particle-bound metal concentrations whilst the epidemiology-based excess risk (ER), the attributable fraction (AF), and the mortality cases were obtained due to exposure to PM10 and PM2.5. CR and HQ were estimated using two methodologies: the first methodology incorporated the particle-bound metal concentrations (As, Cd, Co, Cr, Mn, Ni, Pb) whereas the second methodology used the deposited dose rate of particle-bound metals in the respiratory tract. The indoor concentration accounts for 70% infiltration from outdoor air for the time activity periods allocated to indoor environments. HQ was lower than 1 and the cumulative CR was lower than the acceptable level (10−4), although individual CR for some metals exceeded the acceptable limit (10−6). In a lifetime the estimated number of attributable cancer cases was 74, 0.107, and 217 in Athens, Kuopio, and Lisbon, respectively. Excess risk-based mortality estimates (due to outdoor pollution) for fine particles were 3930, 44.1, and 2820 attributable deaths in Athens, Kuopio, and Lisbon, respectively.
The present study focused on the estimation of the personal dose of airborne particles using an exposure dose model (ExDoM2). Input data from three European cities (Athens, Kuopio, Lisbon) were selected to implement the model that calculates the deposited dose and retention of particles in the respiratory tract, the mass transferred to the oesophagus and the absorption to blood as well as the dose for five particle-bound metals. Model results showed that after one day exposure higher deposited dose in the respiratory tract was obtained for Lisbon as a direct consequence of the higher PM concentration measured in this city. Moreover, the activity profile and the physical characteristics of the exposed subject had strong impact on the estimated deposited dose. Thus, light activity corresponded to higher deposited dose compared to no activity as well as an adult male exhibited higher dose, both findings associated with increased inhalation rate. Regarding the internal dose for particle-bound metals higher dose for four out of the five metals was obtained in lungs followed by the muscles for As, the gastrointestinal tract for Cr, the other tissues for Mn, the intestines for Cd and finally for Pb higher dose was found in bones and blood.
The objective of the current study was to develop a dosimetry model (ExDoM2) for calculating internal dose of specific particle-bound metals (As, Pb, Cd, Cr and Mn) in the human body. The ExDoM2 is a revised version of a respiratory tract model (ExDoM) incorporating a new particle clearance mechanism in the respiratory tract model and a Physiologically-Based PharmacoKinetic (PBPK) model. The revised respiratory tract model was used to calculate the deposition, clearance and retention of particles in the human respiratory tract and the mass transferred to the oesophagus (gastrointestinal tract) and blood. The PBPK module was used to analyze the distribution of metals (As, Pb, Cd, Cr and Mn) from the blood circulation system to other organs or tissues like liver, kidneys, heart, brain, muscle and bone. The model was applied to calculate the internal human dose for an adult Caucasian male exposed to particulate mass matter (PM), PMPb, PMCd, PMMn and PMCr in an urban area (Athens, Greece). The analysis showed that at the end of the exposure (one day exposure scenario) to PMPb, the major accumulation occurs in the bone, blood and muscle, whereas as regards PMCd the major accumulation occurs in the other tissues, like kidney and liver. In addition, for PMMn, the major accumulation occurs in the other tissues and lungs, whereas as regards PMCr the major accumulation occurs in the gastrointestinal (GI) tract and lungs. Therefore, ExDoM2 is an important feature in studying deposition of particles in the human body.
Air pollutants emitted from landfills affect air quality, contribute to the greenhouse effect and may cause serious problems to human health under certain circumstances. The current study was focused on the determination of air emissions from the Akrotiri landfill site which is located in the Akrotiri area (Chania, Greece). The landfill consists of two phases, phase A (first phase) which is currently closed (operational between 2003 and 2007) and phase B (second phase, operation between 2007 and (foreseen) 2013). Three different emission models (the EPA LandGEM model, the triangular model and the stoichiometric model) were used for the quantification of emissions. The LandGEM 3.02 software was further adopted and used in conjunction with the long-term dispersion model ISC3-LT for the evaluation of the dispersion of gaseous chemical components from the landfill. The emission and meteorological conditions under which the models were applied were based on the worst-case emission scenario. Furthermore, the concentration of hydrogen sulfide, vinyl chloride and benzene were determined in and around the landfill site. The concentrations of hydrogen sulfide and benzene were calculated to be far below the limit value proposed by the World Health Organization (WHO) for human health safety. However, the vinyl chloride concentrations were above the WHO reference lifetime exposure health criteria for the phase B area.
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