Developing trend of SDHI fungicide and studies on a novel fungicide, isofetamid

Tsukuda, Shintaro

doi:10.1584/jpestics.w13-35

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…37 Similarly, fluopyram and isofetamid controlled boscalid-resistant isolates of B. cinerea that carried H272R/Y mutations in the sdhB gene. 38,39 As indicated by Scalliet et al, 40 fluopyram does not have a hydrogen bond acceptor in its molecule, and thus its binding seems to be unaffected by the histidine to tyrosine substitution in the SDHB subunit. Nevertheless, the control efficacy of fluopyram was moderate towards H272L, N230I and P225F mutants of B. cinerea, suggesting that the sensitivity to SDHI fungicides varies greatly, depending on the point mutation in the sdhB subunit gene.…”

Section: Discussionmentioning

confidence: 95%

“…found a lack of cross‐resistance to fluopyram in very highly and highly boscalid‐resistant isolates of Corynespora cassiicola carrying H278Y and H278R variations in sdhB , respectively, as well as highly boscalid‐resistant isolates of Podosphaera xanthii (Castaggne) U. Braun & N. Shishkoff carrying the H → Y (homologous to H272Y in B. cinerea ) mutation in sdhB . Similarly, fluopyram and isofetamid controlled boscalid‐resistant isolates of B. cinerea that carried H272R/Y mutations in the sdhB gene . As indicated by Scalliet et al ., fluopyram does not have a hydrogen bond acceptor in its molecule, and thus its binding seems to be unaffected by the histidine to tyrosine substitution in the SDHB subunit.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of SDHI fungicides, including benzovindiflupyr, against Colletotrichum species

Ishii

Fan

et al. 2016

Pest Management Science

108

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This is the first report on the activity of benzovindiflupyr against Colletotrichum species. The broad-spectrum efficacy of benzovindiflupyr within the Colletotrichum genus might be exploited when designing disease management strategies against various pathogens on a wide range of crops. Other mechanism(s) than fungicide target-site modification may be responsible for differential sensitivity of Colletotrichum species to SDHI fungicides. © 2016 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Efficacy of SDHI fungicides, including benzovindiflupyr, against Colletotrichum species

Ishii

Fan

et al. 2016

Pest Management Science

108

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“…Substitution of histidine by tyrosine at codon position 272 in SdhB (B‐H272Y) of Botrytis cinerea and an equivalent substitution in Corynespora cassiicola led to very high resistance to boscalid, although sensitivity to fluopyram remained . Furthermore, the new SDHI isofetamid had a sensitivity profile similar to that of fluopyram when a B‐H272Y mutant of B. cinerea was tested , . Low levels of SDHI resistance in Z. tritici strains carrying Sdh mutations C‐T79 N and C‐W80S were reported in 2012, followed by C‐N86S (2013), B‐N225 T (2014) and B‐T268I (2015) .…”

Section: Introductionmentioning

confidence: 98%

“…20 Furthermore, the new SDHI isofetamid had a sensitivity profile similar to that of fluopyram when a B-H272Y mutant of B. cinerea was tested. 21,22 Low levels of SDHI resistance in Z. tritici strains carrying Sdh mutations C-T79 N and C-W80S were reported in 2012, followed by C-N86S (2013), B-N225 T (2014) and B-T268I (2015). 16 High levels of resistance due to strains carrying Sdh mutation C-H152R were recently reported in Ireland and the UK.…”

Section: Introductionmentioning

confidence: 99%

Non‐target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici

Yamashita

Fraaije

2017

Pest Management Science

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BACKGROUNDA new generation of more active succinate dehydrogenase (Sdh) inhibitors (SDHIs) is currently widely used to control Septoria leaf blotch in northwest Europe. Detailed studies were conducted on Zymoseptoria tritici field isolates with reduced sensitivity to fluopyram and isofetamid; SDHIs which have only just or not been introduced for cereal disease control, respectively.RESULTSStrong cross‐resistance between fluopyram and isofetamid, but not with other SDHIs, was confirmed through sensitivity tests using laboratory mutants and field isolates with and without Sdh mutations. The sensitivity profiles of most field isolates resistant to fluopyram and isofetamid were very similar to a lab mutant carrying SdhC‐A84V, but no alterations were found in SdhB, C and D. Inhibition of mitochondrial Sdh enzyme activity and control efficacy in planta for those isolates was severely impaired by fluopyram and isofetamid, but not by bixafen. Isolates with similar phenotypes were not only detected in northwest Europe but also in New Zealand before the widely use of SDHIs.CONCLUSIONThis is the first report of SDHI‐specific non‐target site resistance in Z. tritici. Monitoring studies show that this resistance mechanism is present and can be selected from standing genetic variation in field populations. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…1), is a new fungicide developed by Ishihara Sangyo Kaisha, Ltd., and is suggested to be an SDHI classified in FRAC code 7 from the similarities of the chemical structure to the existing SDHIs. [7][8][9][10] Isofetamid was registered as a pesticide in Canada in 2014 and introduced into the Japanese market in 2017, and has since been registered worldwide, contributing to the control of various diseases. Although a preliminary study indicated that isofetamid inhibited succinate dehydrogenase activity of Botrytis cinerea, its effects against the enzyme activity of the other sensitive and insensitive fungi, along with plants and mammals were not investigated clearly.…”

Section: Dimethyl-2-(4-isopropoxy-o-tolyl)-2-mentioning

confidence: 99%

Advantageous properties of a new fungicide, isofetamid

Nishimi,

Abe,

Kuwahara

et al. 2024

J. Pestic. Sci.

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The fungicidal properties of a new fungicide, isofetamid, were examined to assess its antifungal spectrum, mode of action, and effects on the infection process of Botrytis cinerea. Additionally, we investigated its fungicidal activity against isolates of B. cinerea resistant to existing fungicides. In mycelial growth inhibition tests, isofetamid exhibited excellent fungicidal activity against ascomycetes but showed no activity against basidiomycetes and oomycetes. Respiratory enzyme assay using mitochondria revealed that isofetamid inhibited succinate dehydrogenase activity prepared from B. cinerea and other ascomycetes fungi used in the study. On the other hand, the activity of mitochondria prepared from Pythium, potato and rat were not inhibited. Isofetamid inhibited also many stages of the infection processes in B. cinerea. Furthermore, it exhibited high fungicidal activity against B. cinerea isolates that were resistant to existing fungicides.

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Developing trend of SDHI fungicide and studies on a novel fungicide, isofetamid

Cited by 9 publications

References 4 publications

Efficacy of SDHI fungicides, including benzovindiflupyr, against Colletotrichum species

Efficacy of SDHI fungicides, including benzovindiflupyr, against Colletotrichum species

Non‐target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici

Advantageous properties of a new fungicide, isofetamid

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