The hand is constantly in contact with products and therefore stressed differently. Heavy stress is the cause of unpleasant sensation and can lead to common hand diseases in the worst case. The chapter starts with the description of hand diseases and with methods to determination of hand stress. Subsequently, the chapter is continued with a literature review of hand stress analysis refer to objectively methods. In the main part, two objective methods are developed and presented to analyze the hand stress. These methods allow the simulation and the measurement of hand stress. Compared to the classical approach, the results of the objective methods show a higher accuracy in faster review of hand stress. Finally, the chapter ends with a discussion of the results and gives opportunities to improve the hand model and the measurement system.