Developing next generation antimicrobials by intercepting AI-2 mediated quorum sensing

Issues of Antibiotic Resistance in Aquaculture Industry and Its Way Forward

“…Quorum quenching (QQ), the disruption of Quorum sensing, can be performed by small antagonists molecules (Givskovm et al, 1996) or signal degrading enzymes (Roy et al, 2011). Many microorganisms can produce enzymes which can degrade N-Acyl homoserinelactones (AHLs) which plays major role in the quorum sensing (Christiaen et al, 2011).…”

Invasion and Survival of Salmonella in the Environment: The Role of Biofilms

“…The pathogenicity of several significant human pathogens has been linked to the activity o f A I -2 q u o r u m s e n s i n g s i g n a l i n g , w h i c h i s a l s o i n v o l v e d w i t h t h e d e v e l o p m e n t o f biofilms (Roy et al, 2011). The ubiquitous nature of AI-2 makes it an excellent target as a potential antimicrobial therapy against a broad spectrum of pathogens.…”

“…However, as with any single piece of the biofilm pathogenicity puzzle, it is unlikely that quorum sensing quenching drugs will be the "magic bullet" for the treatment of bacterial infections. Therefore, according to Roy et al (2011) a mixed therapy of quorum sensing quenchers and traditional antibiotics appears to be a promising approach for the future. Finally, it is important that our understanding of signaling molecules be increased, thereby allowing the identification of potential new antimicrobial therapies.…”

Design and Synthesis of S-ribosylhomocysteine Analogues

“…Pathway for the conversion of SAM to AI. 18 Pei and coworkers in 2003 proposed the pathway for the catalytic mechanism of Sribosylhomocysteine 61,67 presented in Scheme 3. Based on the kinetic, spectroscopic and labeling experiments they proposed that in the first initial step, coordination between the metal in LuxS and a water molecule occurs, making the newly formed open sugar complex 6 act as a Lewis acid.…”

“…The signal molecules in quorum sensing process in Gram positive and negative bacteria. 18 QS was demonstrated to regulate many important traits including biofilm formation, virulence and gene transfer between bacteria. 4,19 Understanding QS may simplify the means to inhibit or silence QS pathway and weaken bacterial pathogenicity.…”