Developing a camera-based 3D momentum imaging system capable of 1 Mhits/s

Debrah, Duke; Stewart, Gabriel; Basnayake, Gihan; Nomerotski, A.; Švihra, Peter; Lee, Suk Kyoung; Li, Wen

doi:10.1063/1.5138731

Cited by 22 publications

(13 citation statements)

References 31 publications

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“…Previous investigations conducted on the Ultraflex III MS coupled with MCP-TPX assembly and the modified LCT (nanoESI-orthogonal acceleration reflectron TOF) MS coupled with HV-floating TPX quad system demonstrated the ability of TPX to detect intact protein ions with m / z values up to 400,000 Da and multiply charged non-covalent protein complexes of molecular weight up to 800,000 Da ( m / z < 13,000 Da). , Here, we extend the m / z detection range of TPX family up to 970,000 Da by the measurement of single-charged intact immunoglobulin M (IgM) ions using the MCP-phosphor screen-TPX3CAM assembly, which has previously been used with great success in velocity map imaging to investigate small-molecule reaction dynamics. − In addition, we demonstrate the utilization of multiple information provided by TPX3 such as TOA, pixel coordinates, and TOT for better visualization of the mass spectrum. We discuss how the reduced dead time and event-based readout in TPX3 compared to the TPX enhances both the low and high mass measurements ( m / z mass range: 757–970,000 Da) and allows the operation of the whole system 10 times faster.…”

Section: Introductionmentioning

confidence: 88%

“… 20 , 21 Here, we extend the m / z detection range of TPX family up to 970,000 Da by the measurement of single-charged intact immunoglobulin M (IgM) ions using the MCP-phosphor screen-TPX3CAM assembly, which has previously been used with great success in velocity map imaging to investigate small-molecule reaction dynamics. 25 − 32 In addition, we demonstrate the utilization of multiple information provided by TPX3 such as TOA, pixel coordinates, and TOT for better visualization of the mass spectrum. We discuss how the reduced dead time and event-based readout in TPX3 compared to the TPX enhances both the low and high mass measurements ( m / z mass range: 757–970,000 Da) and allows the operation of the whole system 10 times faster.…”

Section: Introductionmentioning

confidence: 99%

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Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM

Mathew

Keelor²,

Eijkel

et al. 2022

Anal. Chem.

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The Timepix (TPX) is a position-and time-sensitive pixelated charge detector that can be coupled with time-of-flight mass spectrometry (TOF MS) in combination with microchannel plates (MCPs) for the spatially and temporally resolved detection of biomolecules. Earlier generation TPX detectors used in previous studies were limited by a moderate time resolution (at best 10 ns) and single-stop detection for each pixel that hampered the detection of ions with high mass-to-charge (m/z) values at high pixel occupancies. In this study, we have coupled an MCP-phosphor screen-TPX3CAM detection assembly that contains a silicon-coated TPX3 chip to a matrix-assisted laser desorption/ ionization (MALDI)-axial TOF MS. A time resolution of 1.5625 ns, per-pixel multihit functionality, simultaneous measurement of TOF and time-over-threshold (TOT) values, and kHz readout rates of the TPX3 extended the m/z detection range of the TPX detector family. The detection of singly charged intact Immunoglobulin M ions of m/z value approaching 1 × 10 6 Da has been demonstrated. We also discuss the utilization of additional information on impact coordinates and TOT provided by the TPX3 compared to conventional MS detectors for the enhancement of the quality of the mass spectrum in terms of signal-to-noise (S/N) ratio. We show how the reduced dead time and event-based readout in TPX3 compared to the TPX improves the sensitivity of high m/z detection in both low and high mass measurements (m/z range: 757−970,000 Da). We further exploit the imaging capabilities of the TPX3 detector for the spatial and temporal separation of neutral fragments generated by metastable decay at different locations along the field-free flight region by simultaneous application of deflection and retarding fields.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM

Mathew

Keelor²,

Eijkel

et al. 2022

Anal. Chem.

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“…The experimental setup has been described in detail in previous studies. ,− Here, we will briefly discuss the major components involved in this experiment and modifications that were made to the original configuration. Pulses from a 1 kHz Ti:sapphire two-stage amplified laser (KMLabs Red Dragon, 800 nm, 30 fs, 1 mJ/pulse) were spectrally broadened using a 1 m long hollow-core fiber (Imperial Consultants (ICON) of Imperial College London) filled with argon gas.…”

Section: Methodsmentioning

confidence: 99%

Carrier-Envelope Phase Controlling of Ion Momentum Distributions in Strong Field Double Ionization of Methyl Iodide

et al. 2023

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In strong field ionization of methyl iodide initiated by elliptically polarized few-cycle pulses, a significant correlation was observed between the carrier-envelope phases (CEPs) of the laser and the preferred ejection direction of methyl cation arising from dissociative double ionization. This was attributed to the carrier-envelope phase dependent double ionization yields of methyl iodide. This observation provides a new way for monitoring the absolute CEPs of few-cycle pulses by observing the ion momentum distributions.

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“…The MCP output signal is very fast and can be used to improve the timing resolution, in principle, to the 30-ps level. 27 We tested this approach by employing an intensifier with MCP output connected to a fast 380 MHz ORTEC amplifier after a 1 MHz high-pass filter. The amplifier output was fed to a constant threshold LeCroy discriminator with its digital output time-stamped in the Tpx3Cam TDC with 0.26-ns granulation.…”

Section: Fast Intensified Optical Camerasmentioning

confidence: 99%

Quantum-Assisted Optical Interferometers: Instrument Requirements

Nomerotski,

Stankus,

Slosar

et al. 2020

Preprint

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It has been recently suggested that optical interferometers may not require a phase-stable optical link between the stations if instead sources of quantum-mechanically entangled pairs could be provided to them, enabling extralong baselines and benefiting numerous topics in astrophysics and cosmology. We developed a new variation of this idea, proposing that photons from two different sources could be interfered at two decoupled stations, requiring only a slow classical connection between them. We show that this approach could allow high-precision measurements of the relative astrometry of the two sources, with a simple estimate giving angular resolution of 10 µas in a few hours' observation of two bright stars. We also give requirements on the instrument for these observations, in particular on its temporal and spectral resolution. Finally, we discuss possible technologies for the instrument implementation and first proof-of-principle experiments.

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Developing a camera-based 3D momentum imaging system capable of 1 Mhits/s

Cited by 22 publications

References 31 publications

Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM

Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM

Carrier-Envelope Phase Controlling of Ion Momentum Distributions in Strong Field Double Ionization of Methyl Iodide

Quantum-Assisted Optical Interferometers: Instrument Requirements

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