Detrusor Instability in Men: Correlation of Lower Urinary Tract Symptoms With Urodynamic Findings

Hyman, Michael J.; Groutz, Asnat; Blaivas, Jerry G.

doi:10.1016/s0022-5347(05)65982-4

Cited by 162 publications

(98 citation statements)

References 15 publications

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“…A possible reason for the difference in the uNGF levels between OAB-dry and OAB-wet could be the different degrees of inflammation and a higher percentage of DO (detrusor overactivity) in patients with OAB-wet. Hyman et al (2001) found a higher incidence of DO associated with urgency incontinence (OAB-wet) than with the symptoms of urgency and frequency or nocturia or difficult urination (75 vs 36%). Hashim and Abrams (2006) also found that 69% of men and 44% of women with OAB-dry had DO, while 90% of men and 58% of women with OAB-wet had DO.…”

Section: Discussionmentioning

confidence: 95%

Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis

Yan

Zhang

et al. 2014

Genet. Mol. Res.

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ABSTRACT. To examine whether urinary tract nerve growth factor (uNGF) could be a biomarker for overactive bladder (OAB) symptom, we conducted a comprehensive meta-analysis of 8 case-control studies. In all the studies considered, patients with OAB symptom had a higher uNGF level compared to healthy people. In addition, patients had a significantly lower uNGF level after successful treatment. In the subgroup analysis, we found that patients with OAB-wet symptom had a higher uNGF level than patients with OABdry symptom. However, no significant difference was found between patients with OAB symptom and patients with interstitial cystitis/painful bladder syndrome (IC/PBS) symptom in uNGF/Cr levels. In conclusion, uNGF level could be a useful biomarker for the diagnosis of OAB, a possible biomarker for differentiation between OAB subtypes (wet or dry), and a predictive biomarker for a specific treatment, but it cannot be used as the urinary biomarker for the differential diagnosis of IC/PBS and OAB.

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Section: Discussionmentioning

confidence: 95%

Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis

Yan

Zhang

et al. 2014

Genet. Mol. Res.

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“…When considering our results in a wider clinical context, it is interesting to note that the type of LUTS experienced by men does not always correlate with actual pathophysiological changes. For example, Hyman et al 26 showed that detrusor instability, measured in 160 men, only correlated with urge incontinence (and no other IPSS storage symptoms). In addition, 68% of the men they evaluated had measurable BOO, regardless of the main complaint.…”

Section: Discussionmentioning

confidence: 99%

The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study

Becher

Roehrborn²,

Siami³

et al. 2009

Prostate Cancer Prostatic Dis

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This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged X50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score X12), prostate volume (PV) X30 cm 3 and PSA 1.5-10 ng ml À1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to o42, 42 to o58, X58 cm 3 ). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.

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“…Knutson et al showed DO accompany 55% of patients with LUTS by urodynamic studies (9). Hyman et al stated 46% of patients having LUTS also suffer from DO in 109 patients with LUTS or bladder outlet obstruction (BOO) (10). Similar studies showed this combination can be seen up to 75% of cases (2,(11)(12)(13).…”

Section: Discussionmentioning

confidence: 95%

Efficacy and safety of propiverine and terazosine combination for one year in male patients with luts and detrusor overactivity

et al. 2013

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Purpose: To evaluate the long term efficacy and safety of the use of propiverine and terazosine combination in patients with LUTS and DO by a placebo controlled study. Materials and Methods: One hundred patients were enrolled in the study. They were randomized into two groups (each group consisted of 50 patients). Terazosine and placebo were administered to the patients in Group 1 and terazosine plus propiverine HCL was administered to Group 2. The patients were evaluated by international prostate symptom score (IPSS), the first four questions of IPSS (IPSS4), the 8th question of IPSS (quality of life-QoL), overactive bladder symptom score questionnaire (OAB-q V8), PSA test, urodynamic studies, post voiding residue (PVR). All patients were followed for one year and were reassessed for comparison. Results: IPSS, IPSS4, OAB symptoms, QoL score, PVR, and Qmax scores of the groups did not differ. After one year treatment, there was significant improvement in IPSS, IPSS4, OAB symptoms, QoL and Qmax values in Group 2. No significant improvement was noted for the same parameters in Group 1. Conclusion: This is the first study to show long term safety and efficacy of anticholinergic therapy for patients with LUTS. In patients with OAB or DO, long term anticholinergic treatment may be regarded as a treatment option.

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Detrusor Instability in Men: Correlation of Lower Urinary Tract Symptoms With Urodynamic Findings

Cited by 162 publications

References 15 publications

Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis

Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis

The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study

Efficacy and safety of propiverine and terazosine combination for one year in male patients with luts and detrusor overactivity

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