The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study

Becher, Edgardo; Roehrborn, Claus G.; Siami, Paul; Gagnier, R. Paul; Wilson, Timothy H.; Montorsi, Francesco

doi:10.1038/pcan.2009.37

Cited by 41 publications

(37 citation statements)

References 25 publications

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“…Another hypothesis is that the bladder outlet resistance is decreased if the size of the enlarged prostate, which mechanically obstructs the bladder outlet, is decreased in patients with BPH, thus leading to an improvement in storage symptoms. On the basis of this concept, Becher et al [17] reported that storage symptoms were improved with the use of dutasteride, a type of 5 ARI, alone, and that in the dutasteride and tamsulosin combination treatment group, as compared with the monotherapy group, the storage and voiding subscores were significantly decreased. In addition, the voiding subscore was further decreased.…”

Section: Discussionmentioning

confidence: 99%

Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia

et al. 2011

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PurposeMany patients with benign prostatic hyperplasia (BPH) have storage symptoms. The aim of this study was to evaluate the effects of treatment with a 5-alpha reductase inhibitor (5ARI) on storage symptoms in patients with BPH.MethodsThis study was conducted in 738 patients with lower urinary tract symptoms secondary to BPH. Patients with a prostate volume of higher than 30 mL on the transrectal ultrasound were classified into two groups: group A, in which an alpha blocker was solely administered for at least 12 months, and group B, in which a combination treatment regimen of an alpha blocker plus 5ARI was used. This was followed by an analysis of the changes in parameters such as the total International Prostate Symptom Score (IPSS), voiding symptom subscore, and storage symptom subscore between the two groups. In addition, we examined whether there was a significant difference between the two groups in the degree of change in storage symptoms between before and after the pharmacological treatment.ResultsOf the 738 men, 331 had a prostate volume ≥30 mL, including 150 patients in group A and 181 patients in group B. Total IPSS, the voiding symptom subscore, and the storage symptom subscore were significantly lower after treatment than before treatment in both groups (P<0.05). A comparison of the degree of change between before and after treatment, however, showed no significant differences in the storage symptom subscore between the two groups (P>0.05).ConclusionsAlpha blocker and 5ARI combination treatment is effective for patients with BPH including storage symptoms. However, 5ARI does not exert a significant effect on storage symptoms in BPH patients.

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Section: Discussionmentioning

confidence: 99%

Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia

et al. 2011

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“…Patients being treated with combination therapy experienced a similar reduction in risk of developing acute urinary retention or requiring BPH‐related surgery to that of patients treated with finasteride alone 17 . The Combination of Avodart and Tamsulosin (CombAT) study was the most extensive trial evaluating the efficacy of combination therapy in patients with moderate‐to‐severe LUTS/BPH and enlarged prostates (more than 30 mL) 18 . Combination therapy was shown to lead to greater reductions in storage subscores than dutasteride monotherapy and tamsulosin monotherapy from months 3 and 12, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Discontinuation of Tamsulosin in Korean Men with Benign Prostatic Hyperplasia Taking Tamsulosin and Dutasteride: An Open‐Label, Prospective, Randomized Pilot Study

Lee

Kang

Park

et al. 2011

LUTS

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“…Combination therapy was also more effective than either monotherapy for improvement of voiding symptoms in patients with a prostate volume of 30–42 mL 39. The authors also showed that combination therapy was associated with significantly greater improvement in patient-reported disease-specific quality of life and treatment satisfaction than both monotherapies after treatment for 2 years 4…”

Section: Combination Therapymentioning

confidence: 92%

Effect of combination treatment on patient-related outcome measures in benign prostatic hyperplasia: clinical utility of dutasteride and tamsulosin

Djavan¹,

Dianat²,

Kazzazi³

2011

PROM

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Background:Benign prostatic hyperplasia, the fourth most commonly diagnosed medical condition in the elderly, is a major underlying cause of lower urinary tract symptoms in men. Medical therapy is usually the first therapeutic option. Combination therapy is increasingly used for better symptom relief and outcome.Methods:We searched the literature using the MEDLINE database for the efficacy of combination therapy in men with benign prostatic hyperplasia in terms of symptom improvement and impact on quality of life.Results:Combination therapy with dutasteride and tamsulosin not only provides better symptom improvement and improved urinary flow rate, but is also associated with a more favorable impact on quality of life and patient satisfaction with treatment than monotherapy. Combination therapy also reduces the risk of events related to disease progression, such as acute urinary retention and benign prostatic hyperplasia-related surgery.Conclusion:Combination therapy with dutasteride and tamsulosin is highly efficacious as medical therapy for benign prostatic hyperplasia in patients with moderate-to-severe lower urinary tract symptoms.

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The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study

Cited by 41 publications

References 25 publications

Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia

Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia

Effect of Discontinuation of Tamsulosin in Korean Men with Benign Prostatic Hyperplasia Taking Tamsulosin and Dutasteride: An Open‐Label, Prospective, Randomized Pilot Study

Effect of combination treatment on patient-related outcome measures in benign prostatic hyperplasia: clinical utility of dutasteride and tamsulosin

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