Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food

González-Jartı́n, Jesús M.; Alves, Lisandra de Castro; Alfonso, Amparo; Piñeiro, Yolanda; Vilar, Susana Yáñez; Gómez, Manuel González; Vargas-Osorio, Zulema; Sáinz, M. J.; Vieytes, Mercedes R.; Rivas, José; Botana, Luís M.

doi:10.1016/j.foodchem.2019.05.013

Cited by 34 publications

(23 citation statements)

References 27 publications

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“…However, other mycotoxins—ZEN, OTA, FB1, T-2 and DON range from being moderately hydrophilic to high hydrophobic compounds, therefore being very difficult to adsorb [26]. However, emerging nanocomposites [54], modified organic and inorganic adsorbents [55] are being used to sequester these mycotoxins.…”

Section: Resultsmentioning

confidence: 99%

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Kolawole

Meneely

Greer

et al. 2019

Toxins

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Contamination of animal feed with multiple mycotoxins is an ongoing and growing issue, as over 60% of cereal crops worldwide have been shown to be contaminated with mycotoxins. The present study was carried out to assess the efficacy of commercial feed additives sold with multi-mycotoxin binding claims. Ten feed additives were obtained and categorised into three groups based on their main composition. Their capacity to simultaneously adsorb deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), ochratoxin A (OTA), aflatoxin B1 (AFB1) and T-2 toxin was assessed and compared using an in vitro model designed to simulate the gastrointestinal tract of a monogastric animal. Results showed that only one product (a modified yeast cell wall) effectively adsorbed more than 50% of DON, ZEN, FB1, OTA, T-2 and AFB1, in the following order: AFB1 > ZEN > T-2 > DON > OTA > FB1. The remaining products were able to moderately bind AFB1 (44–58%) but had less, or in some cases, no effect on ZEN, FB1, OTA and T-2 binding (<35%). It is important for companies producing mycotoxin binders that their products undergo rigorous trials under the conditions which best mimic the environment that they must be active in. Claims on the binding efficiency should only be made when such data has been generated.

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Section: Resultsmentioning

confidence: 99%

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Kolawole

Meneely

Greer

et al. 2019

Toxins

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show abstract

“…Therefore, for rapid adsorption kinetics a good adsorbent should possess porosity and high surface area for effective removal of food or environmental toxins. [ 18 ] Some of the significant adsorbents used for the removal of mycotoxins are activated carbon, [ 19 ] carbon nanotubes, [ 20 ] zeolites, [ 21 ] magnetic nano‐particles, [ 22 ] modified, or unmodified clay materials. [ 23 ] Among all these adsorbents, the clay‐based adsorbents are of considerable importance due to low cost, non‐toxic, and ease of modification, however, requires modifications with organic moieties to make them organophilic in nature.…”

Section: Introductionmentioning

confidence: 99%

Green and Eco‐Friendly Removal of Mycotoxins with Organo‐Bentonites; Isothermal, Kinetic, and Thermodynamic Studies

Saeed

Farooq

Nafees

et al. 2020

CLEAN Soil Air Water

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In the current study the application of organo‐modified bentonite for the adsorption of mycotoxins (aflatoxin B1, citrinin, patulin, and zearalenone) is presented. The modification of clays is carried out using benzyl‐tri‐n‐butyl ammonium bromide (BTB), benzethonium chloride (BTC), and dioctyl sodium sulfosuccinate (DSS). Various experimental parameters such as pH, time, adsorbent dose, and mycotoxins concentration are thoroughly studied. The modified clays (B‐BTB, B‐BTC and B‐DSS) are characterized by X‐ray fluorescence, X‐ray diffraction, and Fourier transform infrared spectroscopy. The results depicted the high detoxification efficiency (≈99%) of modified clays for the removal of mycotoxins under optimized conditions (pH 5, time: 30 min, adsorbent amount: 50 mg). The adsorption capacities of modified clays are found in the order of: B‐BTC (AFB1: 18.02, CIT: 18.35, PAT: 18.21, ZEA: 18.09 mg g−1) > B‐BTB (AFB1: 17.7, CIT: 18.11, PAT: 17.95, ZEA: 17.90 mg g−1) > B‐DSS (AFB1: 17.5, CIT: 18.02, PAT: 17.86, ZEA: 17.80 mg g−1). The obtained results fitted well with thermodynamic, isothermal (Langmuir) and pseudo‐second order kinetics. Low cost organo‐modified bentonite shows the promise in mitigating mycotoxin contamination, which could improve food safety and reduce environmental contamination.

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“…Five different pectic oligosaccharides (POSs) from orange peel have been analyzed and a high DE in POS limited its toxin‐binding activity (Di et al., 2017). Moreover, technology in the food industry employing pectins to remove mycotoxins from food, feed and beverages has been reported recently (Gonzalez‐Jartin et al., 2019). Thus, HG pectin possesses great potential to prevent host from toxin‐induced gut inflammation and oligosaccharides may show better protective effects.…”

Section: Regulation Of Ibd By Various Pectic Substancesmentioning

confidence: 99%

Dietary pectic substances enhance gut health by its polycomponent: A review

Linhardt

et al. 2021

Comp Rev Food Sci Food Safe

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Pectic substances, one of the cell wall polysaccharides, exist widespread in vegetables and fruits. A surge of recent research has revealed that pectic substances can inhibit gut inflammation and relieve inflammatory bowel disease symptoms. However, physiological functions of pectins are strongly structure dependent. Pectic substances are essentially heteropolysaccharides composed of homogalacturonan and rhamnogalacturonan backbones substituted by various neutral sugar sidechains. Subtle changes in the architecture of pectic substances may remarkably influence the nutritional function of gut microbiota and the host homeostasis of immune system. In this context, developing a structure–function understanding of how pectic substances have an impact on an inflammatory bowel is of primary importance for diet therapy and new drugs. Therefore, the present review has summarized the polycomponent nature of pectic substances, the activities of different pectic polymers, the effects of molecular characteristics and the underlying mechanisms of pectic substances. The immunomodulated property of pectic substances depends on not only the chemical composition but also the physical structure characteristics, such as molecular weight (Mw) and chain conformation. The potential mechanisms by which pectic substances exert their protective effects are mainly reversing the disordered gut microbiota, regulating immune cells, enhancing barrier function, and inhibiting pathogen adhesion. The manipulation of pectic substances on gut health is sophisticated, and the link between structural specificity of pectins and selective regulation needs further exploration.

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Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food

Cited by 34 publications

References 27 publications

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Green and Eco‐Friendly Removal of Mycotoxins with Organo‐Bentonites; Isothermal, Kinetic, and Thermodynamic Studies

Dietary pectic substances enhance gut health by its polycomponent: A review

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