Detoxication of Anticholinesterase Pesticides

Sogorb, Miguel A.; Vilanova, Eugenio

doi:10.1002/9780470640500.ch10

Cited by 10 publications

(7 citation statements)

References 70 publications

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“…A bulk of the metabolic activation and detoxification of OPs and CMs occur within the liver (Tang et al, 2005;Sogorb and Vilanova, 2010;Vacondio et al, 2010). Due to extensive metabolism of these insecticides in the body, only few metabolites are excreted in the urine that can be used as biomarkers of insecticides exposure.…”

Section: Pharmacokinetics Of Ops and Cmsmentioning

confidence: 98%

“…However, it can also occur due to the presence of other proteins that can bind or inactivate the inhibitor and thereby make it less readily available. Some of the examples for binding to the OPs are carboxylesterases (CarbEs), butyrylcholinesterases (BuChEs) or other binding proteins such as albumin (Sogorb and Vilanova, 2010). In addition, tolerance can be achieved through more rapid metabolism of the OP compounds by OP-hydrolyzing enzymes such as paraoxonases (PONs) and somanases (Fonnum and Sterri, 2006).…”

Section: Tolerance Developmentmentioning

confidence: 99%

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Organophosphates and carbamates

Gupta¹,

Milatović²

2012

Veterinary Toxicology

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Section: Pharmacokinetics Of Ops and Cmsmentioning

confidence: 98%

Section: Tolerance Developmentmentioning

confidence: 99%

Organophosphates and carbamates

Gupta¹,

Milatović²

2012

Veterinary Toxicology

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“…En (5) ocurre el fenómeno de la transmitancia T el cual es la relación de I y I o y que pasa a través de una muestra, por lo tanto: Fuente Autores En términos de sustancias, la absorbancia , también conocida como Densidad Óptica, se define como la relación logarítmica de (Sogorb & Vilanova, 2004), por ende:…”

Section: Perspectiva Teóricaunclassified

Dinámica de la superficie agrícola cultivada en Colombia, 1960-2010

2016

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<p>La inserción de Colombia al mercado global, como consecuencia de la apertura económica ha generado cambios importantes en su economía con efectos en la estructura agraria del país por lo cual es importante conocer la dinámica de comportamiento de la superficie cultivada que permita establecer políticas prospectivas para el desarrollo sectorial. En este sentido el objetivo del estudio fueanalizar la dinámica de la superficie agrícola cultivada en Colombia en el período 1960-2010. Se trabajó con información de (Faostat) que fue analizada utilizando análisis descriptivo exploratorio de tipo unidimensional, análisis comparativos mediante la técnica multivariada de la varianza (Manova), análisis de componentes principales y análisis de correlación método de Spearman. Se encontró una reducción en el área destinada a la agricultura con un incremento del área en ganadería. Se encontró diferencia altamente significativa (p<0.0001) en la superficie cultivada para los principales cultivos. Se detectó diferencia altamente significativa (p<0.0001) en la superficie cultivada para los cultivos evaluados. Algodón, Maíz y Trigo han tenido un decrecimiento notorio en la superficie utilizada, caso contrario al cultivo de hortalizas, frutales, papa, plátano, fríjol y caña de azúcar. El contraste canónico, permitió detectar diferencias entre la década de los 90 respecto a la del 70, 80 y la primera década del siglo XXI. Las políticas públicas implementadas en Colombia han conducido al sector agrario a una reestructuración que ha acrecentado las diferencias entre la agricultura con destino a la agroindustria y la exportación y la agricultura campesina con destino al mercado doméstico.</p>

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“…The resulting phosphorylated enzyme is usually very slowly cleaved, or not at all, and remains inhibited. In some cases, the recovery by spontaneous reactivation may occur at a significant speed 46 or be forced by nucleophilic reagents such as fluoride or oximes ( Figure 1). Besides, the phosphoryl enzyme can undergo a dealkylating reaction called aging.…”

Section: Inhibition and Reactivation Of Esterases And Cholinesterasesmentioning

confidence: 99%

Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds

Mangas

Vilanova

Estévez

et al. 2016

Journal of the Brazilian Chemical Society

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Organophosphorus compounds (OPs) are a large and diverse class of chemicals that have been synthesized, since the XIX century for several purposes like chemical weapons, flame-retardants, ectoparasiticides and investigational new drugs, but mainly as agrochemicals in agriculture and indoor. Although the amount of OP pesticides being used is declining, especially in developed countries, OPs continue being one of the most important classes of insecticides and chemical warfare agents today due to its toxic effects on the enzyme acetylcholinesterase (AChE). Existing research on the toxicological effects of OPs is extensive, however, there is a lack of knowledge on the long-term effects of low levels of OPs and their exactly pathways of toxicity. Recent data prove that other molecular targets than AChE could be targeted by OPs, triggering these effects. Here these data are reviewed and it is highlighted that the current uses of OPs are producing several neurotoxic effects. It is also shown that, to protect people from possible uses and misuses of OPs, more regulations on OPs are needed. Moreover, more mechanistic studies are needed to completely understand their toxicological interactions and mechanisms of action and to identify the whole group of enzymes that interact with them.

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Detoxication of Anticholinesterase Pesticides

Cited by 10 publications

References 70 publications

Organophosphates and carbamates

Organophosphates and carbamates

Dinámica de la superficie agrícola cultivada en Colombia, 1960-2010

Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds

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