Determining the relative importance of titania nanotubes characteristics on bone implant surface performance: A quality by design study with a fuzzy approach

Martinez-Marquez, Daniel; Gulati, Karan; Carty, Christopher P.; Stewart, Rodney Anthony; Ivanovski, Sašo

doi:10.1016/j.msec.2020.110995

Cited by 40 publications

(25 citation statements)

References 198 publications

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“…However, to further develop an effective QbD engineering strategy for the development of specific bone implants it is important to identify the degree of importance of each bone scaffold characteristic according to the implant's future location within the human body. This can be identified by following the second step in the QbD system, namely Critical Quality Attributes (CQA), as detailed described in previous work [222]. CQA are product characteristics that must fall within specific limits to comply with the quality standards defined in the QTPP.…”

Section: Discussionmentioning

confidence: 99%

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

et al. 2020

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Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way. This study used the QbD system to explore the Quality Target Product Profile and Ideal Quality Attributes of additively manufactured titanium porous scaffolds for bone regeneration with a biomimetic approach. For this purpose, a total of 807 experimental results extracted from 50 different studies were benchmarked against proposed target values based on bone properties, governmental regulations, and scientific research relevant to bone implants. The scaffold properties such as unit cell geometry, pore size, porosity, compressive strength, and fatigue strength were studied. The results of this study may help future research to effectively direct the design process under the QbD system.

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Section: Discussionmentioning

confidence: 99%

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

et al. 2020

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“…That is why most of the proposed medical materials fall into the 'valley of death.' This death valley is an interesting recent term coined by Martinez-Marquez et al [256] for the life-cycle product development of medical devices and shows that the majority of products failed due to the large investment needed for pre-clinical and clinical trials, subsequently limiting the clinical translation and commercialisation. An improved setting of anodic oxidation (optimised AO [69,95,334]) is now regarded as the industry front-runner when compared to other techniques in terms of simplicity and low-cost surface processing.…”

Section: Cost-efficiency and Safety Of Tio 2 Anodic Layers As Implant's Coating Materialsmentioning

confidence: 99%

“…Simultaneous testing of wear and corrosion in one test system is known as a tribocorrosion test ( currently using various unstandardised design/setup of tribometer ) [ 280 , 287 , 304 ] or biotribology test [ 256 , 327 ], all of which were conducted in a wet-contact environment between the sample and the test system ( tribometer ). To date, most of the reported trials of the anodised titanium tribocorrosion properties have been able to estimate the mechanical stability of the coating as a whole once it has been in contact with the bodily fluids [ 256 , 280 , 287 , 304 , 327 ]. Despite the limited literature, development of standards and test protocols for testing the tribocorrosion properties of anodic TiO 2 layers is lacking.…”

Section: Current Challenges In Using Tio 2 Anodic Layermentioning

confidence: 99%

“…On the other hand, a study of AO [ 2 ] has shown that this electrochemical process is highly flexible [ 69 , 334 ] and easy to conduct [ 70 , 95 ], offering wide variety of anodic TiO 2 layer properties including excellent biocompatibility [ 8 , 271 ] good mechanical stability [ 16 , 314 ], through multifunctional nanostructured films [ 11 , 49 ], nano-morphologies [ 44 , 79 , 162 ], complex hierarchical topographies [ 35 , 45 , 92 , 248 ], and surface biofunctionalisation [ 73 , 74 , 280 , 314 ], whereas all of which were feasible to be implemented as implant coatings [ 72 , 290 , 311 ] and with an economical scale-up or optimised fabrication [ 69 , 95 , 256 , 334 ].…”

Section: Future Trend Of the Anodised Titanium In The Implant's Coating Evolutionsmentioning

confidence: 99%

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Evolution of anodised titanium for implant applications

Alipal

Lee

Koshy

et al. 2021

Heliyon

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Anodised titanium has a long history as a coating structure for implants due to its bioactive and ossified surface, which promotes rapid bone integration. In response to the growing literature on anodised titanium, this article is the first to revisit the evolution of anodised titanium as an implant coating. The review reports the process and mechanisms for the engineering of distinctive anodised titanium structures, the significant factors influencing the mechanisms of its formation, bioactivity, as well as recent pre-and post-surface treatments proposed to improve the performance of anodised titanium. The review then broadens the discussion to include future functional trends of anodised titanium, ranging from the provision of higher surface energy interactions in the design of biocomposite coatings (template stencil interface for mechanical interlock) to techniques for measuring the boneto-implant contact (BIC), each with their own challenges. Overall, this paper provides up-to-date information on the impacts of the structure and function of anodised titanium as an implant coating in vitro and in/ex vivo tests, as well as the four key future challenges that are important for its clinical translations, namely (i) techniques to enhance the mechanical stability and (ii) testing techniques to measure the mechanical stability of anodised titanium, (iii) real-time/in-situ detection methods for surface reactions, and (iv) cost-effectiveness for anodised titanium and its safety as a bone implant coating.

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“…TiO 2 nanotubes are one of the promising bone/dental implant surface modification strategies with enhanced bioactivity and local therapeutic functions [ 12 , 13 , 14 ]. Recently, there has been an increased interest in investigating nanoscale surface topographies as biomimetic interfaces for implantable devices.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium

et al. 2021

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The objective of this study was to investigate the potential of titanium nanotubes to promote the proliferation of human osteoblasts and to reduce monomicrobial biofilm adhesion. A secondary objective was to determine the effect of silicon carbide (SiC) on these nanostructured surfaces. Anodized titanium sheets with 100–150 nm nanotubes were either coated or not coated with SiC. After 24 h of osteoblast cultivation on the samples, cells were observed on all titanium sheets by SEM. In addition, the cytotoxicity was evaluated by CellTiter-BlueCell assay after 1, 3, and 7 days. The samples were also cultivated in culture medium with microorganisms incubated anaerobically with respective predominant periodontal bacteria viz. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia as monoinfection at 37 °C for 30 days. The biofilm adhesion and coverage were evaluated through surface observation using Scanning Electron Microscopy (SEM). The results demonstrate that Ti nanostructured surfaces induced more cell proliferation after seven days. All groups presented no cytotoxic effects on human osteoblasts. In addition, SEM images illustrate that Ti nanostructured surfaces exhibited lower biofilm coverage compared to the reference samples. These results indicate that Ti nanotubes promoted osteoblasts proliferation and induced cell proliferation on the surface, compared with the controls. Ti nanotubes also reduced biofilm adhesion on titanium implant surfaces.

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Determining the relative importance of titania nanotubes characteristics on bone implant surface performance: A quality by design study with a fuzzy approach

Cited by 40 publications

References 198 publications

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

Evolution of anodised titanium for implant applications

Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium

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