Determining the efficacy of functional liver imaging score (FLIS) obtained from gadoxetic acid-enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Albumin-Bilirubin (ALBI) grade and FLIS

Evaluation of liver function in patients with liver cirrhosis and chronic liver disease using functional liver imaging scores at different acquisition time points

“…In this study, EnQS, ExQS and PVsQS demonstrated a weak to moderate negative correlation with ICG-R 15 , ALBI score, CP score and MELD score except for ExQS at 5 min after enhancement, which was in line with those reported in the literature. Moreover, intra- and inter-observer ICCs were >0.90 for FLIS at 5, 10, and 15 min, which was also consistent with previous studies ( Bastati et al, 2016 ; Bastati et al, 2020 ; Lee et al, 2021 ; Aslan et al, 2022 ; Luo et al, 2022 ).…”

“…In this study, EnQS, ExQS and PVsQS demonstrated a weak to moderate negative correlation with ICG-R 15 , ALBI score, CP score and MELD score except for ExQS at 5 min after enhancement, which was in line with those reported in the literature. Moreover, intra-and inter-observer ICCs were >0.90 for FLIS at 5, 10, and 15 min, which was also consistent with previous studies (Bastati et al, 2016;Bastati et al, 2020;Lee et al, 2021;Aslan et al, 2022;Luo et al, 2022). Previous studies have shown that a delay of 10 min is sufficient for diagnosis in patients without a history of CLD; for patients with mild liver dysfunction, a 15-min delay is enough to diagnose; and for patients with moderate or severe liver dysfunction, > 5 min delay is not effective (Motosugi et al, 2009b;van Kessel et al, 2012;Esterson et al, 2015;Liang et al, 2016).…”

“…Through comparing the FLIS and CP scores, Lee et al (2021) found that AUC, specificity and sensitivity were 0.938%, 94.4%, and 83.7%, respectively, when predicted CLD and CP A cirrhosis by FLIS≥5, and that AUC, specificity and sensitivity were 0.896, 92.9%, and 81.8%, respectively, when predicted CP B cirrhosis between CP B and C cirrhosis by FLIS≥3. In the same way, Aslan et al (2022) compared FLIS and ALBI scores to find that AUC, specificity and sensitivity were 0.882–0.917, 82.6%–87%, and 83.7%–95.4%, respectively, when predicted ALBI grade 1 by FLIS≥5, and that AUC, specificity and sensitivity were 0.974–0.994, 95.2%–96%, and 100%, respectively, when distinguished ALBI grade 3 from other grades by FLIS≤3. These findings revealed that FLIS may be used clinically to non-invasively assess the liver function reserve.…”

“…FLIS had a moderate negative correlation with liver function classification at each time point (−0.587, −0.580, and −0.547 for ICG-R 15 ; −0.515, −0.564, and −0.538 for ALBI score; −0.574, −0.622, and −0.641 for CP score; −0428, −0.555, and −0.507 for MELD score; 5-, 10-, and 15-min delay, respectively) (p < 0.05). In previous work, FLIS and its three parameters showed a strong correlation with CP score (r = −0.80) and ALBI grade (r = [−0.976] to [−0.951]) (Lee et al, 2021;Aslan et al, 2022). However, Luo et al (2022) reported that FLIS was weakly correlated only with ICG-R 15 , ALBI score, and MELD score (r = [−0.268] to [−0.219]).…”

“…Similarly, an algorithm based on splenic craniocaudal diameter and FLIS has also been reported to independently predict transplant-free mortality and to effectively stratify transplant-free survival in patients with advanced CLD ( Bastati et al, 2022 ). Furthermore, FLIS is strongly correlated with CP score and ALBI score in patients with liver cirrhosis (LC) and CLD, and patients can be classified according to CP grade or ALBI grade ( Lee et al, 2021 ; Aslan et al, 2022 ). However, it was reported by Luo et al (2022) that FLIS was weakly linked to ICG-R 15 , ALBI score, and MELD score.…”