Determining the effects of anthelmintic drugs on the equine intestinal microbiome

Kunz, I.G.Z.; Reed, Kailee J.; Metcalf, Jessica L.; Coleman, Robert J.; Coleman, S. J.

doi:10.1016/j.jevs.2017.03.038

Cited by 2 publications

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“…The taxa identified in the baseline samples, and in other samples throughout the experiment, are consistent with other studies in horses under similar management conditions [12]. Although, the predominant phyla identified are not consistent with previously generated data from this particular group of horses [165,166]. Significant differences in -diversity associated with sample collection day suggest that differences in the presence and abundance of certain taxa may be correlated with the temporal impact of anthelmintic administration.…”

Section: Discussionsupporting

confidence: 75%

Equine Fecal Microbiota Changes Associated With Anthelmintic Administration

Kunz

Reed

Metcalf

et al. 2019

Journal of Equine Veterinary Science

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Section: Discussionsupporting

confidence: 75%

Equine Fecal Microbiota Changes Associated With Anthelmintic Administration

Kunz

Reed

Metcalf

et al. 2019

Journal of Equine Veterinary Science

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“…To the authors' knowledge this is the first study to evaluate the effect of either anthelmintic treatment on the fecal microbiome of dogs. A recent pilot study identified a subtle effect on the gastrointestinal microbiome after administration of a single dose of moxidectin/praziquantel in horses [30]. Another study found alterations in the gastrointestinal microbiota in Amur tigers after they received tablets containing fenbendazole and ivermectin [31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections

et al. 2020

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Background The gastrointestinal microbiome plays an important role in host health and there is increasing concern regarding the deleterious effects of pharmaceuticals on the fecal microbiome. The effect of anthelmintic therapy on the fecal microbiome in dogs has not yet been evaluated. The purpose of this study was to evaluate the effect of anthelmintic administration on the fecal microbiome of dogs with and without subclinical Giardia species and Cryptosporidium canis infections. Methodology/Principal findings Part 1: 6 healthy adult research beagles with subclinical giardiasis and cryptosporidiosis were administered a commercially available preparation of febantel combined with pyrantel and praziquantel (FPP) orally daily for three days. Part 2: 19 healthy staff-owned dogs without giardiasis or cryptosporidiosis were divided into a treatment group (n = 9) that was administered fenbendazole orally daily for five days and an untreated control group (n = 10). For both parts of the study, feces were collected at multiple time points before and after anthelmintic (FPP or fenbendazole) administration. Fecal DNA was extracted for Illumina sequencing of the bacterial 16S rRNA gene and qPCR assays. Neither FPP nor fenbendazole treatment caused a significant change in alpha or beta diversity or the relative abundance of bacterial species. Upon univariate statistical analysis neither FPP or fenbendazole caused minimal changes in the fecal microbiota. Conclusion FPP administration was associated with minimal alterations of the fecal microbiome of healthy research beagles with subclinical giardiasis and cryptosporidiosis. Fenbendazole

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Determining the effects of anthelmintic drugs on the equine intestinal microbiome

Cited by 2 publications

References 0 publications

Equine Fecal Microbiota Changes Associated With Anthelmintic Administration

Equine Fecal Microbiota Changes Associated With Anthelmintic Administration

Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections

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