Determining the correlation between Cobb angle severity and bone mineral density in women with adolescent idiopathic scoliosis

Almomen, Firas A.; Altaweel, Abdullah; Abunadi, Abdulhameed K.; Hashem, Abdullah E.; Alqarni, Rayan M.; Alsiddiky, Abdulmonem

doi:10.1016/j.jtumed.2020.12.019

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…We found that piezo1 11aa del/11aa del at 3 months of age had predominantly lower TMD values than the wildtype (Figure 3C). This is consistent with various reports when they assessed the bone mineral density in scoliotic patients (Sarioglu et al, 2019;Li et al, 2020;Almomen et al, 2021).…”

Section: Resultssupporting

confidence: 93%

Piezo1 Mutant Zebrafish as a Model of Idiopathic Scoliosis

Ramli,

Aramaki,

Watanabe

et al. 2023

Preprint

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Scoliosis is a condition where the spine curves sideways, unique to humans due to their upright posture. However, the cause of this disease is not well understood because it's challenging to find a model for experimentation. This study aimed to create a model for human idiopathic scoliosis by manipulating the function of mechanosensitive channels called Piezo channels in zebrafish. Zebrafish were chosen because they experience similar biomechanical forces to humans, particularly in relation to the role of mechanical force in scoliosis progression. Here we describe piezo1 and piezo2a are involved in bone formation, with a double knockout resulting in congenital systemic malformations. However, an in-frame mutation of piezo1 led to fully penetrant juvenile-onset scoliosis, bone asymmetry, reduced tissue mineral density, and abnormal intervertebral discs-resembling non-congenital scoliosis symptoms in humans. These findings suggest that functional Piezo channels responding to mechanical forces are crucial for bone formation and maintaining spine integrity, providing insights into skeletal disorders.

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Section: Resultssupporting

confidence: 93%

Piezo1 Mutant Zebrafish as a Model of Idiopathic Scoliosis

Ramli,

Aramaki,

Watanabe

et al. 2023

Preprint

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“…However, A recent study of Almomen et al 24 reported a higher incidence of low bone mass (62.9% and 74.1% for lumbar and femoral BMD, respectively). This may be due to their study involved AIS patients with Cobb angles ≥ 40 o .…”

Section: Discussionmentioning

confidence: 92%

Serum Vitamin D Level and Bone Mineral Density Among Adolescent Idiopathic Scoliotic Patients

Hammoud

Aly

Yehia

et al. 2021

Al-Azhar International Medical Journal

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Background: Low bone mineral density (BMD) and hypovitaminosis D were found to be associated in adolescent idiopathic scoliosis (AIS) patients. The incidence of AIS with osteoporosis is believed to reduce the intensity of the bone by about 20-38 percent. Aim of TheWork: To assess serum vitamin D level and BMD in patients with adolescent scoliosis. Patients and Methods: This work involved 112 patients diagnosed with AIS and a Cobb angle > 10o aged from 10 -18 years old. Vitamin D level, Cobb angle and BMD measured in all subjects. Results: Our result included 112 patients, seventy-four (66.1%) of the patients had vitamin D deficiency. Osteopenia present in 39% and osteoporosis in 25% of AIS patients by lumbar spine Z-score and by hip Z-score, osteopenia present in 53% and osteoporosis in 12% of AIS patients. Conclusion: Study concluded that majority of AIS patients have low serum vitamin D level and low BMD.

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“…Li et al reported that AIS patients had poorer bone mineral density of the bilateral femoral neck than controls ( 13 ), and lower bone volume from the histological sections of the spinous process taken from AIS patients was found ( 33 ). Besides, Almomen et al reported that female AIS patients with greater higher Cobb angles exhibited a significantly higher risk of low bone density ( 34 ). Our study is the first to use the HU value obtained from CT scans to evaluate the bone quality of vertebral bodies in AIS patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluating bone quality and asymmetrical aplasia of the thoracic vertebral body in Lenke 1A adolescent idiopathic scoliosis using hounsfield units

Chen

Hu²,

Yan³

et al. 2022

Front. Surg.

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Study DesignRetrospective analysis.ObjectiveTo evaluate bone quality and investigate asymmetrical development of the thoracic vertebral body in adolescent idiopathic scoliosis (AIS) based on Hounsfield unit (HU) measurements obtained from computed-tomography (CT) scans.Summary of Background DataHU value demonstrated higher reliability and accuracy than the traditional method, indicating that they could be used to individually evaluate and effectively assess the bone quality of every vertebra in the CT films.MethodsTotal 30 AIS patients classified as Lenke Type 1A and 30 paired controls were included in this study. Regions of interest for HU value were measured on three horizontal images of the thoracic vertebrae. HU measurements of the whole vertebral body in each vertebra were obtained. Using HU value, we separately measured the concave and convex sides of each vertebral body in patients' group, as well as within the left and right sides in controls.ResultsIn controls, the mean HU value of T1–T12 thoracic vertebral bodies was 240.03 ± 39.77, with no statistical differences among different levels. As for AIS patients, in the structural curve, the apical region had a significantly lower HU compared with the other regions, and asymmetrical change was found between the concave and convex sides, most significantly in the apical region. In the non-structural curve, the average HU value was 254.99 ± 44.48, and no significant difference was found either among the different levels of vertebrae or between the concave and convex sides.ConclusionsAbnormal and asymmetrical changes in bone quality of the thoracic vertebral body in patients with Lenke 1A AIS were indicated. Low bone quality in the convex side of the structural curve indicated stronger internal fixation in surgery to correct the deformity.

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Determining the correlation between Cobb angle severity and bone mineral density in women with adolescent idiopathic scoliosis

Cited by 9 publications

References 12 publications

Piezo1 Mutant Zebrafish as a Model of Idiopathic Scoliosis

Piezo1 Mutant Zebrafish as a Model of Idiopathic Scoliosis

Serum Vitamin D Level and Bone Mineral Density Among Adolescent Idiopathic Scoliotic Patients

Evaluating bone quality and asymmetrical aplasia of the thoracic vertebral body in Lenke 1A adolescent idiopathic scoliosis using hounsfield units

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