Piezo1 Mutant Zebrafish as a Model of Idiopathic Scoliosis
Ramli,
Toshihiro Aramaki,
Masakatsu Watanabe
et al.
Abstract:Scoliosis is a condition where the spine curves sideways, unique to humans due to their upright posture. However, the cause of this disease is not well understood because it's challenging to find a model for experimentation. This study aimed to create a model for human idiopathic scoliosis by manipulating the function of mechanosensitive channels called Piezo channels in zebrafish. Zebrafish were chosen because they experience similar biomechanical forces to humans, particularly in relation to the role of mech… Show more
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