Determining mean corpuscular volume and red blood cell count using electrochemical collision events

Ho, Thy L.T.; Hoang, Nhung Thi–Tuyet; Lee, Jungeun; Park, Jun Hui; Kim, Byung Kwon

doi:10.1016/j.bios.2018.03.053

Cited by 43 publications

(32 citation statements)

References 21 publications

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“…Nano-and microbeads of polystyrene as well as micro-droplets of organic solvents and ionic liquid were also imaged using this platform [30][31]. Ho et al report the detection of red blood cell and an estimation of their size to detect anemia related to an abnormal size (6 to 12 µm diameter) [32]. Dick et al reported the specific detection of individual virus [33].…”

Section: Applications From Biosensing To Study Of Nanobubblesmentioning

confidence: 99%

Detection of individual insulating entities by electrochemical blocking

Deng

Renault

2021

Current Opinion in Electrochemistry

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Section: Applications From Biosensing To Study Of Nanobubblesmentioning

confidence: 99%

Detection of individual insulating entities by electrochemical blocking

Deng

Renault

2021

Current Opinion in Electrochemistry

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“…(iv) Determination of Mean Corpuscular Volume (MCV) Determination of MCV was carried out according to the method described by [26]. The mean corpuscular volume was calculated using the formula below…”

Section: Determination Of Haematological Parametersmentioning

confidence: 99%

Changes in Haematological Parameters Following Toxicity Study with 80% Methanol Extract of <i>Moringa oleifera</i> in Wistar Rats

Hassan¹,

Saidu²,

Ishaq³

et al. 2020

AJAC

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To determine the acute toxicity effects of Moringa oleifera leaf extract on haematological parameters, twenty albino Wistar rats weighing between 108-254 g were split into four groups of fives rat each. Different doses of the extract were administered to the 3 groups and one group is used as control. Moringa oleifera 80% methanol leaf extract was administered at 2000 mg/kg to group, 1000 mg/kg to group, and 500 mg/kg while one group was used as control. The result recorded 4 deaths (60% mortality) in groups that received 2000 mg/kg and 1 death (20% mortality) in groups that received 1000 mg/kg. Blood samples were collected from the survived rats for hematological analysis. The result showed variation in Park cell volume (PCV), hemoglobin concentration (Hb), Red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC). There are significant differences at p > 0.05, p > 0.01 and p > 0.001 between groups that exposed to different doses Moringa oleifera extract and the control group. The result also shows slight variation in total and differential leucocyte count, but all the values obtained from both treated and control groups are within the normal range. There are no recorded values of eosinophil, basophil and band cells in both the control and the experimental groups. From this result, it can be concluded that high dose of this extract caused alteration in normal red cells indices with significant differences, but have mild or no effect on total and differential leucocyte count. Hence, low toxicity of this plant made it safe and good medicinal agent and or supplement. Histopatological screening as well as phytochemical study to identify the compounds that affect the blood chemistry is highly recommended.

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“…Examples include hydrogen evolution measured at single Pt nanoparticles and clusters, [9] reduction and oxidation of single Ag nanoparticles, [10,11] H 2 O 2 oxidation measured on single IrO x nanoparticles, [12,13] single collisions of toluene-in-water emulsion droplets, [14] oxygen reduction at single enzymes, [15] or the collision of single red blood cells with an electrode surface. [16] The stochastic collision approach to single entity electrochemistry is simple to implement, high resolution, and high throughput. Over 10's of seconds the experimenter can measure 1000's of single entities, providing robust statistics while continuing to work at a single entity level.…”

Section: Introductionmentioning

confidence: 99%

Microscale Electrochemical Cell on a Custom CMOS Transimpedance Amplifier for High Temporal Resolution Single Entity Electrochemistry**

et al. 2020

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Stochastic collision electrochemistry requires high-resolution and high-bandwidth current amplification due to the low magnitude and short duration of the current signals. However, increasing the current amplifier bandwidth leads to increased current noise levels, which in turn obscures the current signal generated from stochastic collision electrochemistry experiments. The key to minimizing current noise is an experimental configuration that minimizes the input capacitance to the current amplifier. Here, we report a new strategy to minimize the input capacitance to a current amplifier by using a movable microscale electrochemical cell, formed at the end of a micropipette using a scanning electrochemical cell microscopy approach, to conduct electrochemical experiments in close proximity (~300 μm) to a transimpedance amplifier. We demonstrated this via electro-oxidation of single Ag nanoparticles detected at a bandwidth of 1 MHz.

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Determining mean corpuscular volume and red blood cell count using electrochemical collision events

Cited by 43 publications

References 21 publications

Detection of individual insulating entities by electrochemical blocking

Detection of individual insulating entities by electrochemical blocking

Changes in Haematological Parameters Following Toxicity Study with 80% Methanol Extract of <i>Moringa oleifera</i> in Wistar Rats

Microscale Electrochemical Cell on a Custom CMOS Transimpedance Amplifier for High Temporal Resolution Single Entity Electrochemistry**

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Determining mean corpuscular volume and red blood cell count using electrochemical collision events

Cited by 43 publications

References 21 publications

Detection of individual insulating entities by electrochemical blocking

Detection of individual insulating entities by electrochemical blocking

Changes in Haematological Parameters Following Toxicity Study with 80% Methanol Extract of &lt;i&gt;Moringa oleifera&lt;/i&gt; in Wistar Rats

Microscale Electrochemical Cell on a Custom CMOS Transimpedance Amplifier for High Temporal Resolution Single Entity Electrochemistry**

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Changes in Haematological Parameters Following Toxicity Study with 80% Methanol Extract of <i>Moringa oleifera</i> in Wistar Rats