Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method

Lucca, Letícia Grolli; Matos, Sheila Porto de; Borille, Bruna Tassi; Dias, Daiane; Teixeira, Hélder Ferreira; Veiga, Valdir Florêncio da; Limberger, Renata Pereira; Koester, Letícia Scherer

doi:10.1016/j.jpba.2014.11.013

Cited by 47 publications

(23 citation statements)

References 21 publications

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“…High abundance of peaks was observed at a retention time (Rt) of 44.715 min. Analysis on the mass spectra ( Figure 2) and comparison with the NIST library and with data in the literature (Lucca et al, 2015) revealed a fragmentation pattern in accordance with b-caryophyllene.…”

Section: Gas Chromatograph Analysismentioning

confidence: 77%

“…An oleoresin nanoemulsion from C. multijuga had previously been successfully achieved, but it was produced using volatile organic solvents, through a spontaneous nanoemulsifying method (Dias et al, 2014). A high-pressure homogenizer has also been used for the preparation of C. multijuga oleoresin nanoemulsions (Dias et al, 2012(Dias et al, , 2014Lucca et al, 2015). Vaucher et al (2015) also used this high-energy method for preparing a nanoemulsion from C. officinalis oleoresin.…”

Section: Discussionmentioning

confidence: 99%

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Effects of a nanoemulsion with Copaifera officinalis oleoresin against monogenean parasites of Colossoma macropomum: A Neotropical Serrasalmidae

Valentim

Duarte

Oliveira

et al. 2018

Journal of Fish Diseases

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Monogeneans are ectoparasites that may cause losses in production and productivity in the aquaculture of Colossoma macropomum. Chemotherapeutics used in aquaculture usually have major adverse effects on fish; hence, the use of essential oils has been considered advantageous, but these are not soluble in water. Thus, the use of nanostructures to enhance water solubility of compounds and improve bioactivity may be very promising. This study investigated the antiparasitic activity of nanoemulsion prepared with Copaifera officinalis oleoresin (50, 100, 150, 200 and 300 mg/L), against monogenean parasites from the gills of C. macropomum. The particle size distribution and zeta potential suggested that a potentially kinetic stable system was generated. The nanoemulsion from C. officinalis oleoresin achieved high efficacy (100%) at low concentrations (200 and 300 mg/L) after 15 min of exposure. This was the first time that a nanoemulsion was generated from C. officinalis oleoresin using a solvent-free, non-heating and low-energy method. Moreover, this was the first time that an antiparasitic against monogeneans on fish gills, based on nanoemulsion of C. officinalis oleoresin, was tested.

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Section: Gas Chromatograph Analysismentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Effects of a nanoemulsion with Copaifera officinalis oleoresin against monogenean parasites of Colossoma macropomum: A Neotropical Serrasalmidae

Valentim

Duarte

Oliveira

et al. 2018

Journal of Fish Diseases

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“…After topical application of C.O to the skin, β‐caryophyllene is retained exclusively in the SC . As the C.O used in the present study has a relatively high β‐caryophyllene content (~31%), it is possible that both β‐caryophyllene and Cxb become retained in the SC due to their high lipophilicity.…”

Section: Discussionmentioning

confidence: 91%

Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

Quiñones

Hossy

Pádua

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Estudos quanto à permeação do OR de C. duckei também não foram encontrados na literatura. No entanto, Lucca et al (2015) concluíram que a permeação de β-cariofileno por nanoemulsão apresentou uma melhor penetração na pele em comparação com o óleo in natura, pois tal formulação atingiu a derme, uma camada mais profunda. Assim, a escolha da formulação por nanoemulsão em gel seria a melhor escolha quando do objetivo de permeação dos ativos do OR de copaíba.…”

Section: Teste De Transmissibilidade -unclassified

Avaliação da transmissibilidade ultrassônica do gel fitoterápico de Copaifera duckei Dwyer

et al. 2017

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RESUMO.-Esse estudo teve por objetivo avaliar o potencial de transmissibilidade ultrassônica de um gel fitoterápico de copaíba da espécie Copaifera duckei Dwyer na concentração de 10%. A pesquisa foi registrada junto ao Sistema Brasileiro de Biodiversidade. O gel fitoterápico de Copaifera duckei 10% foi manipulado de acordo diretrizes da Farmacopéia Brasileira e testado em um aparelho de Ultrassom (US) operado na faixa de 1 MHz. Como grupos controle foram selecionados a água destilada e o gel hidroalcoólico. A análise ocorreu de forma qualitativa e quantitativa através do modelo proposto na literatura. O US foi programado para modos de corrente pulsado/contínuo e testados nas intensidades (0,2/0,4/0,6/0 This study aimed to evaluate the potential of transmissibility of an herbal gel of Copaifera duckei Dwyer at a concentration of 10%. The research was registered with the Brazilian Biodiversity System. The gel of Copaifera duckei 10% was guidelined by the Brazilian Pharmacopoeia and tested on an Ultrasound device (US) operated in the range of 1 MHz. The control groups were selected distilled water and hydro alcoholic gel. The analysis was qualitatively and quantitatively using the model proposed in the literature. The US was scheduled to current modes pulsed/continuous and tested in the intensities (0.2/0.4/0.6/0.8/1.0W/cm2) in 1mim/cm2. The data received statistical treatment by BioEstat software 5.3 and was admitted to a significance level of ≥0.05. In continuous mode and intensity of 0.2W/cm2 gel was considered "good transmitter" at the intensity of 0.4W/ cm2 and 0.6W/cm2 a "moderate Transmitter" and the intensity of 0.8W/cm2 and 1.0W/ cm2 a "poor transmitter". It was concluded that the 10% gel C. duckei US did not attenuate US waves in any form or intensity tested; it can thus be used for this treatment being considered a good or moderate transmitter according to the intensity of US.

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Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method

Cited by 47 publications

References 21 publications

Effects of a nanoemulsion with Copaifera officinalis oleoresin against monogenean parasites of Colossoma macropomum: A Neotropical Serrasalmidae

Effects of a nanoemulsion with Copaifera officinalis oleoresin against monogenean parasites of Colossoma macropomum: A Neotropical Serrasalmidae

Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

Avaliação da transmissibilidade ultrassônica do gel fitoterápico de Copaifera duckei Dwyer

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