Determination of zafirlukast by stability indicating LC and derivative spectrophotometry

Radhakrishna, T; Satyanarayana, J.; Satyanarayana, A.

doi:10.1016/s0731-7085(02)00346-1

Cited by 15 publications

(10 citation statements)

References 10 publications

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“…Moreover the proposed methods described have better sensitivity than HPLC [9,11] and spectrophotometric [11] methods in literature. Comparison of the developed methods and HPLC methods [9,11], shows the advantages of the prior one due to its simplicity, low cost, short time analysis and selectivity.…”

Section: Resultsmentioning

confidence: 93%

“…Comparison of the developed methods and HPLC methods [9,11], shows the advantages of the prior one due to its simplicity, low cost, short time analysis and selectivity. These proposed methods may be preferred to HPLC method for determination of ZAF in pharmaceutical formulations.…”

Section: Resultsmentioning

confidence: 99%

“…The obtained percentage recoveries and the relative standard deviations based on the average of seven replicate measurements were found ( Table 7). The obtained results were compared to those obtained by a reported spectrophotometric method [11]. The statistical comparison of methods was done by Wilcoxon paired test (t c = 9 > t t = 2, p > 0.05 for OSWV method and t c = 15 > t t = 2, p > 0.05 for OSWAdSV method).…”

Section: Oswv Methodsmentioning

confidence: 99%

“…The most commonly employed techniques such as high-performance liquid chromatography (HPLC) [9][10][11] and derivative spectrophotometry [11] for the determination of ZAF are mentioned in pharmaceutical formulation and biological samples in literature.…”

Section: Introductionmentioning

confidence: 99%

“…The developed methods were applied to the determination of ZAF in pharmaceutical formulations. The results obtained by the developed methods were compared with the spectrophotometric method in the literature [11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods

Süslü

Altınöz

2005

Journal of Pharmaceutical and Biomedical Analysis

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Oswv Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods

Süslü

Altınöz

2005

Journal of Pharmaceutical and Biomedical Analysis

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Development and validation of a sensitive LC‐MS/MS method with electrospray ionization for quantitation of zafirlukast, a selective leukotriene antagonist in human plasma: application to a clinical pharmacokinetic study

Bharathi

Naidu

Jagadeesh

et al. 2008

Biomedical Chromatography

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A highly sensitive and specific LC-MS/MS method has been developed and validated for the estimation of zafirlukast (ZFK) with 500 microL human plasma using valdecoxib as an internal standard (IS). The API-4,000 LC-MS/MS was operated under multiple reaction-monitoring mode using the electrospray ionization technique. The assay procedure involved extraction of ZFK and IS from human plasma with ethyl acetate. The resolution of peaks was achieved with 10 mm ammonium acetate (pH 6.4):acetonitrile (20:80, v/v) on a Hypersil BDS C(18) column. The total chromatographic run time was 2.0 min and the elution of ZFK and IS occurred at approximately 1.11 and 1.58 min, respectively. The MS/MS ion transitions monitored were 574.2 --> 462.1 for ZFK and 313.3 --> 118.1 for IS. The method was proved to be accurate and precise at a linearity range of 0.15-600 ng/mL with a correlation coefficient (r) of >or=0.999. The method was rugged with 0.15 ng/mL as lower limit of quantitation. The intra- and inter-day precision and accuracy values were found to be within the assay variability limits as per the FDA guidelines. The developed assay method was applied to a pharmacokinetic study in human volunteers following oral administration of 20 mg ZFK tablet.

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A LC Separation and Quantification of o‐Toluene Sulphonamide and its Related Positional Isomers Using a Cellulose tris(3,5‐dimethyl phenylcarbamate)

Krishnaiah

Reddy

Kumar

et al. 2010

J Chinese Chemical Soc

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A simple, rapid, selective and sensitive high performance liquid chromatographic method was developed for the separation and quantification of o-Toluene Sulphonamide and its positional isomers which is an intermediate of Zafirlukast drug substance using a chiral column. Elution time was below 10 min in normal phase mode and ultra violet detection was carried out at 220 nm. Efficient separation was achieved on a Chiralcel OD-H column using of n-Hexane and 2-Propanol mixture (50:50 v/v) as isocratic at 1.0 mL min -1 flow rate. Resolutions between m-Toluene Sulphonamide and p-Toluene Sulphonamide isomers of o-Toluene Sulphonamide were found to be > 2.5. The calibration graphs for m-Toluene Sulphonamide and p-Toluene Sulphonamide isomers of o-Toluene Sulphonamide were linear (R 2 > 0.999) when ranging from the limit of quantitation to 0.5%. The method is found to be selective, precise, linear, accurate and also robust. It was used for not only Quality assurance but also monitoring the synthetic reactions involved in the process development of Zafirlukast. The liquid chromatographic method is found to be specific and reliable for the determination of unreacted levels of positional isomers in reaction mass. This method was successfully validated according to the International Conference Harmonization (ICH) guidelines (Validation of Analytical Procedures: Test and Methodology Q2).

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Determination of zafirlukast by stability indicating LC and derivative spectrophotometry

Cited by 15 publications

References 10 publications

Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods

Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods

Development and validation of a sensitive LC‐MS/MS method with electrospray ionization for quantitation of zafirlukast, a selective leukotriene antagonist in human plasma: application to a clinical pharmacokinetic study

A LC Separation and Quantification of o‐Toluene Sulphonamide and its Related Positional Isomers Using a Cellulose tris(3,5‐dimethyl phenylcarbamate)

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