Determination of traces of iodide in serum and urine by ion chromatography

Buchberger, Wolfgang; Winsauer, K.

doi:10.1007/bf01196833

Cited by 16 publications

(7 citation statements)

References 13 publications

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“…Typical I Ϫ and total iodine (organic bound ϩ free iodide) concentrations in serum for healthy patients are in the range 2 to 4 and Ϸ80 g L Ϫ1 , respectively (16). The determination of the total amount of iodine in biological materials has become a routine procedure (17), whereas the determination of free inorganic I Ϫ in biological samples in the presence of iodinated organic compounds still remains a problem, although there is a considerable amount of interest from the medical point of view. While the physiological significance of chloride and iodide is well known, bromide is still considered as either a nonessential trace element or a trace element with an unknown function (18).…”

Section: Figmentioning

confidence: 99%

Chloride-Sensitive Fluorescent Indicators

Geddes

Apperson

Karolin

et al. 2001

Analytical Biochemistry

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Section: Figmentioning

confidence: 99%

Chloride-Sensitive Fluorescent Indicators

Geddes

Apperson

Karolin

et al. 2001

Analytical Biochemistry

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“…Typical I − and total iodine (organic bound + free iodide) concentrations in serum for healthy patients are in the range 2-4 µg l −1 and ≈80 µg l −1 respectively (Michalke et al 1996). The determination of the total amount of iodine in biological materials has become a routine procedure (Buchberger and Winsauer 1985), whereas the determination of free inorganic I − in biological samples in the presence of iodinated organic compounds still remains a problem, although there is a considerable amount of interest from the medical viewpoint.…”

Section: Halide In Human Physiologymentioning

confidence: 99%

Optical halide sensing using fluorescence quenching: theory, simulations and applications - a review

Geddes¹

2001

Meas. Sci. Technol.

253

247

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In the last century the production and application of halides assumed an ever greater importance. In the fields of medicine, dentistry, plastics, pesticides, food, photography etc many new halogen containing compounds have come into everyday use. In an analogous manner many techniques for the detection and determination of halogen compounds and ions have been developed with scientific journals reporting ever more sensitive methods. The 19th century saw the discovery of what is now thought of as a classical method for halide determination, namely the quenching of fluorescence. However, little analytically was done until over 100 years after its discovery, when the first halide sensors based on the quenching of fluorescence started to emerge. Due to the typical complexity of fluorescence quenching kinetics of optical halide sensors and their lack of selectivity, they have found little if any place commercially, despite their sensitivity, where other techniques such as ion-selective electrodes, x-ray fluorescence spectroscopy and colorimetry have dominated the analytical market. In this review article the author summarizes the relevant theory and work to date for halide sensing using fluorescence quenching methods and outlines the future potential that fluorescence quenching based optical sensors have to offer in halide determination.

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“…This procedure yielded a practically quantitative recovery of iodide as has been shown in earlier work. 15 In the chromatogram an additional peak at 3 min can be seen; in this region one can expect the elution of various matrix compounds that might yield fragment ions with m/z 127. Improvements in detection limits of iodide might be possible by using larger injection volumes and interface designs that tolerate higher flow rates of aqueous mobile phases.…”

Section: Resultsmentioning

confidence: 98%

Preliminary comparison of inductively coupled plasma mass spectrometry and electrospray mass spectrometry hyphenated with ion chromatography for trace analysis of iodide

Buchberger

Czizsek

Stingeder

2003

J. Anal. At. Spectrom.

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Ion-exchange chromatography hyphenated with mass spectrometric detection has been investigated for the determination of iodide in urine. Satisfactory chromatographic behavior of iodide could be achieved on a hydrophilic polymer-based anion-exchange column with 35 mM sodium hydroxide as the mobile phase. When electrospray ionization (ESI) was used, a suppressor as well as a flow splitter (split ratio 1 : 10) was required between the column and the interface. In the case of an inductively coupled plasma (ICP) ionization source, eluent and flow-rate were completely compatible with the interface. Under comparable chromatographic conditions, the ESI interface yielded a detection limit of 15 mg L 21 (quadrupole instrument), whereas the ICP interface lowered the detection limits by approximately two (quadrupole instrument) and three (sector field instrument) orders of magnitude. For urine samples both methods gave virtually the same results except for the relative standard deviation, which was 7% for ESI and 0.55% for sector field ICP. The molecule-selective detection of ESI may be an advantage in cases when insufficient separation from other iodine-containing species cannot be avoided. The element-selective ICP will be the preferred tool when iodide has to be determined in the sub-ppb range.

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Determination of traces of iodide in serum and urine by ion chromatography

Cited by 16 publications

References 13 publications

Chloride-Sensitive Fluorescent Indicators

Chloride-Sensitive Fluorescent Indicators

Optical halide sensing using fluorescence quenching: theory, simulations and applications - a review

Preliminary comparison of inductively coupled plasma mass spectrometry and electrospray mass spectrometry hyphenated with ion chromatography for trace analysis of iodide

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