Determination of the β− branching ratio of 64Cu by mass spectrometric investigations of the decay products in neutron transmuted copper

Fully Automated Production and Characterization of 64Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using 64Cu‐Labelled CA XII Targeting 6A10 Fab

“…We therefore assume that the majority of the nickel originates from the nickel target. Minor amounts of non‐radioactive Ni and Zn can be attributed to 64 Cu decay, as it is characterized by 39.0±3 % β − decay to 64 Zn ground state, and 17.86±14 % β + and 42.6±5 % electron capture decay to 64 Ni ground state . Co, Cr and Mn were not found in significant amounts.…”

“…Radiolabelling such molecules with an intermediate half‐life PET nuclide such as 64 Cu ( t 1/2 =12.7 h) might therefore be promising. Furthermore, in addition to β + and electron capture, 64 Cu decay includes a significant β − component (probability of 39.0±3 %) . Thus, the combination of PET imaging with radiotherapy may be feasible, which is not the case for 124 I and 89 Zr …”

“…Furthermore,i na ddition to b + and electron capture, 64 Cu decay includes as ignificant b À component (probability of 39.0 AE 3%). [13][14][15] Thus, the combination of PET imaging with radiotherapy may be feasible, which is not the case for 124 Iand 89 Zr. [16][17][18][19] Various kinds of molecules have been radiolabelled with 64 Cu to investigate possible PET applications against aw ide range of diseases.O ne of the most common 64 Cu-radiolabelling methods is based on the use of ac helatinga gent to bind the radioactive metal to the carrier molecule.…”

Thermal Ionisation Mass Spectrometry

“…Relevant for the present discussion are 238 U (abundance: 99.7 mole%), which decays to 206 Pb by a decay chain with an overall half-life of 4486.3 Ma (decay constant: 1.55125Â10 À10 a À1 ) and 235 U (abundance: 0.3 mole%) that decays to 207 Pb by another decay chain with an overall halflife of 703.8 Ma (decay constant: 9.8485Â10 À10 a À1 ). Th has one long-lived isotope, 232 Th that decays to 208 Pb with a half-life of 14.0 Ga (decay constant: 4.94752Â10 À11 a À1 ). Pb has 5 naturally occurring isotopes, 204 Pb, 206 Pb, 207 Pb, 208 Pb, 210 Pb.…”

“…This branching ratio was determined by Wermann et al applying ID-TIMS. 232 Solid copper with low Zn and Ni impurities was irradiated in a nuclear reactor. The ingrowth of 64 Ni and 64 Zn, caused by the decay of the 64 Cu produced from stable 63 Cu by irradiation with thermal and epithermal neutrons, was determined by ID-TIMS.…”