Determination of the release of PEG and HPMC from nelfilcon A daily disposable contact lenses using a novel <i>in vitro</i> eye model

Phan, Chau-Minh; Walther, Harald; Smith, Richard; Riederer, D. E.; Lau, Charis; Lorenz, Kathrine Osborn; Subbaraman, Lakshman N.; Jones, Lyndon

doi:10.1080/09205063.2018.1514192

Cited by 12 publications

(19 citation statements)

References 34 publications

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“…Commercial versions of nelfilcon A use three moisturising agents, including high molecular weight HPMC and low molecular weight PEG in their packaging solution and continue to have PVA in the material matrix [205]. In vitro studies have shown that there was significantly greater release of PEG than HPMC, with both exhibiting a 'burst release' pattern that predominantly occurred in the initial 1.5 h following lens insertion [206].…”

Section: Effect Of Wetting Agents In Blister Packsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Effect Of Wetting Agents In Blister Packsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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“…Therefore, understanding of the polymer degradation phenomena is a crucial aspect in the design of controlled DDSs. Several papers have investigated the degradation rate and drug release profile of bioresorbable polymeric matrices by MS (Table , Figure ) …”

Section: Bioresorbable Polymer Drug Release Tracking By Msmentioning

confidence: 99%

“…The elution of PEG and HPMC from DACP lenses was studied using LC/ESI MS. LC/ESI MS experiments with PEG and HPMC showed distinctive peaks representative of the polymer. LC/MS data showed that the release of all wetting agents from the lenses followed a burst release pattern, which occurred within the first 1.5 h. Moreover, the release of PEG was greater than that of HPMC . Peer et al provided new insights into how the surface nanopatterning of biomaterials can functionalize the surface and tailor the release kinetics of therapeutic agents coated on it for controlled drug elution.…”

Section: Bioresorbable Polymer Drug Release Tracking By Msmentioning

confidence: 99%

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

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A detailed characterization of polymeric matrices and appropriate degradation monitoring techniques are required to sustain the development of new materials as well as to enlarge the applications of the old ones. In fact, polymer analysis is essential for the clarification of the intrinsic relationship between structure and properties that ascertains the industrial applications in diverse fields. In bioresorbable and biodegradable polymers, the role of analytical methods is dual since it is pointed both at the polymeric matrices and at degradation tracking. The structural architectures, the mechanical and morphological properties, and the degradation rate, are of outstanding importance for a specific application. In some cases, the complexity of the polymer structure, the processes of decomposition or the low concentration of the degradation products need the concurrent use of different complementary analytical techniques to give detailed information of the reactions taking place. Several analytical methods are used in bioresorbable polymer development and degradation tracking. Among them, mass spectrometry (MS) plays an essential role and it is used to refine polymer syntheses, for its high sensitivity, to highlight degradation mechanism by detecting compounds present in trace amounts, or to track the degradation product profile and to study drug release. In fact, elucidation of reaction mechanisms and polymer structure, attesting to the purity and detecting defects as well as residual catalysts, in biodegradable and bioresorbable polymers, requires sensitive analytical characterization methods that are essential in providing an assurance of safety, efficacy and quality. This review aims to provide an overview of the MS strategies used to support research and development of resorbable polymers as well as to investigate their degradation mechanisms. It is focused on the most significant studies concerning synthetic bioresorbable matrices (polylactide, polyglycolide and their copolymers, polyhydroxybutyrate, etc.), published in the last ten years.

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“…The data showed a rapid release of the wetting agent. 21 Sterner et al evaluated the tribological performance of two macromolecules, hyaluronic acid and PVP, wherein the high-molecular-weight PVP had the lowest values of the coefficient of friction. 22 Abd El-Rehim et al developed a nanogel by cross-linking poly(acrylic acid) and PVP to reduce the viscosity of poly(acrylic acid).…”

Section: Introductionmentioning

confidence: 99%

“…Phan et al prepared soaked contact lenses to release hydroxypropyl methylcellulose (HPMC) and poly(ethylene glycol) (PEG) from Nelfilcon A using a novel in vitro eye model (OcuFlow). The data showed a rapid release of the wetting agent . Sterner et al evaluated the tribological performance of two macromolecules, hyaluronic acid and PVP, wherein the high-molecular-weight PVP had the lowest values of the coefficient of friction .…”

Section: Introductionmentioning

confidence: 99%

Novel Poly(vinylpyrrolidone)-Coated Silicone Contact Lenses to Improve Tear Volume During Lens Wear: In Vitro and In Vivo Studies

et al. 2020

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Poly(vinylpyrrolidone) (PVP-K90) is widely used to manage dry eye syndrome (DES). The marketed eye drop solutions (high dose) need frequent instillation, affecting the routine lifestyle of patients. PVP-K90-laden contact lenses can be used to overcome the limitations of eye drop solutions (low bioavailability and frequent instillation). However, the conventional methods of PVP-K90 loading show poor loading capacity and short duration of effect. In the present study, we have developed PVP-K90-coated contact lenses via a short curing approach to increase the PVP-K90 loading capacity with a sustained release profile to manage dry eye syndrome. PVP-K90 was loaded by a soaking method (SM-PVP), direct loading (during fabrication, DL-PVP), a combination of soaking and direct loading (DL-SM-PVP), and a novel coating process (SM-PVP-C and DL-SM-PVP-C). The swelling studies suggested improvement in the water uptake (hydration) property of the contact lenses due to the presence of PVP-K90. The optical transparency was within an acceptable range. The in vitro release of PVP-K90 was in the following order: PVP-coated contact lens (168 h) > DL-SM-PVP (168 h) > DL-PVP (96 h) > SM-PVP (72–96 h). PVP-coated contact lenses showed a high burst effect (lubricating effect) and sustained release (3161–448 ng/h between 24 and 168 h) due to high PVP loading/coating in comparison to the uncoated respective contact lenses (964–113 ng/h between 24 and 96 h). In animal studies, the PVP-K90-coated contact lens showed higher tear volume in comparison to the respective uncoated contact lenses and an eye drop solution. This study demonstrates a novel approach of coating a high amount of PVP-K90 on contact lenses for sustained release to manage several ocular diseases like dry eye syndrome, conjunctivitis, and other ocular injuries.

show abstract

Determination of the release of PEG and HPMC from nelfilcon A daily disposable contact lenses using a novel in vitro eye model

Cited by 12 publications

References 34 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Novel Poly(vinylpyrrolidone)-Coated Silicone Contact Lenses to Improve Tear Volume During Lens Wear: In Vitro and In Vivo Studies

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