Determination of the Ketoconazole by Green Sequential Injection Spectrophotometry

Liawruangrath, Saisunee; Prasertboonyai, Kanyarak

doi:10.1080/00032719.2020.1764970

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Most common approach used in development of sequential injection and flow analysis methods is still univariate optimization. [18][19][20] More detailed study of zone penetration and other parameters of importance could decrease number of experiments in later phases. When programs of wider scope are used, it is necessary to adapt their functions to a specific application, which can be timeconsuming and demanding.…”

Section: Introductionmentioning

confidence: 99%

LabVIEW virtual instrument for zone penetration studies in flow-based analytical systems

Kuljanin

Gros

2021

JSCS

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In the flow method development, zone penetration studies are usually conducted as a part of initial screening phase. A lack of an appropriate tool can keep these studies on the level of rough estimations. The developed LabVIEW virtual instrument (VI) which processes peak signals and calculates the overlapping area and fundamental peak-related parameters was used for calculations in experiments that are modelling sample and reagent plug interaction within liquid conduits. The reliability of the predictions was initially confirmed on the artificial data set based on thirty-six files covering all the different types of cases that can be foreseen. In the continuation, volumes of model solutions, propelling flow rate, and coil length in the sequential injection analysis system, were varied by following Box-Behnken response surface design. In three examples, it is demonstrated how the VI can help us plan further experiments in the range which ensures efficient zone overlapping, economic exploitation of reagent plug and adequate dispersion. The application of the VI is not limited just to flow-based chemistry, it can also be useful in spectroscopy and chromatography. To utilize the graphical user interface, it is not necessary to have the LabVIEW program installed.

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Section: Introductionmentioning

confidence: 99%

LabVIEW virtual instrument for zone penetration studies in flow-based analytical systems

Kuljanin

Gros

2021

JSCS

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“…The European Pharmacopeia recommends using potentiometric titration for species like fenticonazole, econazole, ketoconazole, isoconazole, bifonazole, fluconazole, and itraconazole, while for voriconazole indicates to use liquid chromatography. 21 A literature survey revealed the use of other methods to determine these compounds, such as high-performance liquid chromatography (HPLC) with UV detection, 22 HPLC with diode array detection (HPLC-DAD), 23 HPLC-tandem mass spectrometry (HPLC-MS/MS), 24,25 liquid chromatography-tandem mass spectrometry (LC-MS/MS), [26][27][28] reversedphase HPLC (RP-HPLC) with UV detection, 29 sequential injection analysis (SIA) with spectrophotometric detection, 30 spectrophotometry, 31,32 and capillary electrophoresis (CE). [33][34][35] Although these techniques are widely used due to their robustness, sensitivity, and reliability, they require large amounts of reagents, expensive equipment, sample pretreatment, and specialized personnel.…”

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confidence: 99%

Review—Electrochemical Sensors Used for the Determination of Some Antifungal Azoles

Tuchiu

Staden²,

Staden³

2022

ECS Sens. Plus

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Antifungal agents are essential drugs used to treat fungal infections caused by various types of fungi. Due to their mechanism of action, these drugs bear serious adverse reactions, interact with a wide range of other drugs, and negatively impact the environment. Therefore, there is a need for accurate, sensitive, and reliable detection methods to minimize and possibly avoid their potential negative effects. Although so far classical methods have proven to be effective in detecting these drugs, some of their disadvantages have led the scientific community to focus its efforts on electrochemical methods, as they are simple to use, sensitive, and require a small quantity of sample and minimal sample pretreatment. This mini-review focuses on electrochemical sensors developed between 2017 and 2022 for the detection and quantification of antifungal azoles, highlighting their response characteristics, sensitivity, and applicability in real samples analysis.

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Unique green chromatographic method for the qualitative and quantitative analysis of ketoconazole, its impurities and preservatives from ketoconazole cream formulation: Identification of degradants by Q-ToF LCMS and Robustness by Design of Experiments

Muchakayala,

Katari,

Saripella

et al. 2023

Sustainable Chemistry and Pharmacy

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Determination of the Ketoconazole by Green Sequential Injection Spectrophotometry

Cited by 4 publications

References 19 publications

LabVIEW virtual instrument for zone penetration studies in flow-based analytical systems

LabVIEW virtual instrument for zone penetration studies in flow-based analytical systems

Review—Electrochemical Sensors Used for the Determination of Some Antifungal Azoles

Unique green chromatographic method for the qualitative and quantitative analysis of ketoconazole, its impurities and preservatives from ketoconazole cream formulation: Identification of degradants by Q-ToF LCMS and Robustness by Design of Experiments

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