Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B

Wulamu, S.; Yimamu, H.; Abuduwaili, Aytursun; Mutailifu, Paiheerding; Maksimov, V. V.; Gao, Yanli; Yili, Abulimiti; Aisa, Haji Akber

doi:10.1007/s10600-019-02657-z

Cited by 4 publications

(2 citation statements)

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“…In another study, the sequential extraction of F. sinkiangensis roots yielded 28.86 wt% total polysaccharides. The polysaccharide fractions are heteropolysaccharides, containing galacturonic and glucuronic acids, galactose, xylose, rhamnose, fructose, and arabinose [ 47 ].…”

Section: Phytoconstituents Of F Sinkiangensismentioning

confidence: 99%

“…In another study, the PTP1B inhibitory potential of the different polysaccharides fractions was estimated. It was noted that the inhibitory capacity of the tested fractions elevated with raising their galactose content, therefore, galactose may be a ligand for blocking PTP1B catalytic site [ 47 ].…”

Section: Biological Activities Of F Sinkiangensis ...mentioning

confidence: 99%

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Ferula sinkiangensis (Chou-AWei, Chinese Ferula): Traditional Uses, Phytoconstituents, Biosynthesis, and Pharmacological Activities

Khayat

Alharbi

Ghazawi

et al. 2023

Plants

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Ferula is the third largest genus of the Apiaceae family, its species are utilized as a remedy for diverse ailments all over the world. F. sinkiangensis K. M. Shen (Chou-AWei, Chinese Ferula) is mainly found in Xin-jiang Uygur Autonomous Region, China. Traditionally, it is utilized for treating various illnesses such as digestive disorders, rheumatoid arthritis, wound infection, baldness, bronchitis, ovarian cysts, intestinal worms, diarrhea, malaria, abdominal mass, cold, measles, and bronchitis. It can produce different classes of metabolites such as sesquiterpene coumarins, steroidal esters, lignans, phenylpropanoids, sesquiterpenes, monoterpenes, coumarins, organic acid glycosides, and sulfur-containing compounds with prominent bioactivities. The objective of this work is to point out the reported data on F. sinkiangensis, including traditional uses, phytoconstituents, biosynthesis, and bioactivities. In the current work, 194 metabolites were reported from F. sinkiangensis in the period from 1987 to the end of 2022. Nevertheless, future work should be directed to conduct in vivo, mechanistic, and clinical assessments of this plant`s metabolites to confirm its safe usage.

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Section: Phytoconstituents Of F Sinkiangensismentioning

confidence: 99%

Section: Biological Activities Of F Sinkiangensis ...mentioning

confidence: 99%