Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration

Abdelbary, Ghada A.; Eouani, C.; Prinderre, P.; Joachim, J; Reynier, Jean-Pierre; Piccerelle, Philippe

doi:10.1016/j.ijpharm.2004.08.019

Cited by 127 publications

(67 citation statements)

References 10 publications

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“…The limitation of this method is that one side of the tablet is attached to the probe and cannot interact with the immersion medium, whereas in the oral cavity the tablet will be moistened on all sides and this can enhance disintegration. 25 Friability: Roche friabilator was used for the purpose. This device subjects a number of tablets to the combined effect of abrasion and shock by utilizing a plastic chamber that revolves at 25 rpm for 4 min dropping the tablets at a distance of 6 inches with each revolution.…”

Section: Post-compression Parametersmentioning

confidence: 99%

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Rv¹,

Pande²,

Sonawane³

2015

Adv Pharm Bull

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Section: Post-compression Parametersmentioning

confidence: 99%

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Rv¹,

Pande²,

Sonawane³

2015

Adv Pharm Bull

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“…The readings were taken immediately and at several intervals over a period of 10 min. Oral DT of the optimized ODT formulation (determined based on its in vitro DT and drug release) was assessed on six healthy male human volunteers according to the procedure described by Abdelbary et al (11). The subjects were informed of the purpose and protocol of the study.…”

Section: Evaluation Of Dxm Oral Disintegrating Tabletsmentioning

confidence: 99%

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

et al. 2010

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Oral disintegrating tablets (ODTs) have advantages of solid dosage forms such as good stability, accurate dosing, small packaging size, and easy handling, as well as those of liquid formulations such as easy administration and minimal risk of suffocation. Therefore, they are beneficial for children, elderly and schizophrenic patients who have difficulty in swallowing conventional solid dosage forms (1). The success of ODT depends on patient acceptance, palatability and the challenging aspect in the formulation of orally disintegrating tablets is to mask the bitterness of active pharmaceutical ingredients, since most drugs have bitter taste. The distasteful sensation of a drug can be masked either by the addition of flavors, sweeteners and effervescent agents or by reducing direct contact with the patient's taste buds through coating or granulation (2, 3). Flavor is often overpowered by the taste of the medicine and the use of effervescent agents is not always convenient. Moreover, coating and granulation of the active ingredient may The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age groups. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of the particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calculated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.

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“…While originally developed for specific patient groups such as the pediatric, geriatric, patients with dysphagia as well as travelling patients, ODTs have since gained popularity amongst the Page 4 of 29 A c c e p t e d M a n u s c r i p t 3 wider patient population (Abdelbary et al, 2005). To allow this expansion in ODT application, 40 the number of ODT technologies has increased with a major shift from lyophilisation towards conventional tableting.…”

Section: Introductionmentioning

confidence: 99%

Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

Pabari¹,

Ramtoola²

2012

International Journal of Pharmaceutics

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Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration

Cited by 127 publications

References 10 publications

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

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