Determination of the effects of Alcohol Dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey

Aktaş, Ekin Özgür; Koçak, Aytaç; Şenol, Ender; Celik, Handan; Çoşkunol, Hakan; Berdelı, Afig; Aydin, Hikmet Hakan

doi:10.1016/j.scijus.2011.05.002

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…The relationship between the ADH1C*2 variant and increased susceptibility to alcohol use disorder was not verified in this study. Similarly, an association of the genotype (Val/Val) or its allele with alcohol use disorder was not observed in the Turkish population (Aktas et al, 2012). Rebello et al (2011) suggested a possible association between ADH1C*2 (form Ile/Val) and alcohol dependence in southeastern Brazil.…”

Section: Discussionmentioning

confidence: 93%

“…Li et al (2011) confirmed that the His allele greatly reduces the risk of addiction as well as diseases acquired through excessive alcohol consumption, particularly in Asian populations. The ADH1B*1/ADH1B*1 genotype and the wild-type allele, which favor alcohol dependence, have been observed among Polish and Turkish populations (Aktas et al, 2012;Cichoż-Lach et al, 2010).…”

Section: Discussionmentioning

confidence: 98%

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Allelic variations in alcohol metabolism genes (ADH1B, ADH1C, CYP2E1) and alcohol use disorder (AUD) in northeastern Brazil

Melo¹,

Rocha

Carvalho

et al. 2022

RSD

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Alcohol use disorder (AUD) is a multifactorial disease caused by environmental and genetic factors. Genetic polymorphisms of the enzymes involved in alcohol metabolism influence the susceptibility to alcohol dependence. The distribution of the genetic variants varies depending on ethnicity. The aim of this study was to evaluate the effects of the polymorphisms of the three genes responsible for the degradation of ethanol, ADH1B, ADH1C, and CYP2E1 to examine the influence of these mutations on the risk for alcohol use disorder in a population from northeastern Brazil. In addition, the allelic distribution of the northeastern population will be compared with that obtained for other populations. The allelic and genotypic frequencies were determined in 163 alcoholic patients and 182 control subjects. Genotyping was performed by PCR-RFLP. The allele frequencies in the northeastern population were similar to those reported in studies in Mexico but differed significantly from those reported in studies of a Chinese population. The polymorphic variants of CYP2E1 were associated with a higher risk for alcohol use disorder [odds ratio (OR) = 2.80; 95% confidence interval (CI) = 1.35-5.83, p = 0.0072]. No significant result was obtained from the analyses of the ADH1C gene. A significant protective effect against alcohol dependence was observed in individuals carrying allelic and genotypic variations of the ADH1B gene, as determined through the combined analysis of homozygous and heterozygous variant forms of the gene in controls and alcoholics (P = 0.03). Furthermore, the combination of ADH1B*2 with ADH1C*1 and CYP2E1 (c1/c1) may confer protection against alcohol use disorder.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Allelic variations in alcohol metabolism genes (ADH1B, ADH1C, CYP2E1) and alcohol use disorder (AUD) in northeastern Brazil

Melo¹,

Rocha

Carvalho

et al. 2022

RSD

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“…These reports are contradictory, since the protective effect of Ile350 against risk of AD is consistently reported in different Asian populations [35,36] than in non-Asian populations [19,37]. However, in a Turkish study, rs698 was not associated with AD whereas rs1229984 (Arg47His, also referred to as ADH1B*2) which is in high linkage disequilibrium with rs698 was associated with AD [38]. rs698 and the another allelic variant of ADH1C*2 rs1693482 were found to be in high LD with rs1789891 (a SNP located between ADH1B and ADH1C) is significantly associated with AD [39].…”

Section: Discussionmentioning

confidence: 95%

Association of ADH1C and ALDH2 genes with alcohol dependence in south Indian Tamilian population

Arunachalam¹,

Manoharan

Kannan

et al. 2022

ijhs

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Objectives: Alcohol dependence (AD) poses a serious medical problem and significant public health issue contributing to morbidity and mortality throughout the world. The aim of the study was to establish the allele and genotype frequencies and to test the association of rs698 (ADH1C) and rs671(ALDH2) with the risk of alcohol dependence in south Indian Tamilian population. Methodology: A total of 150 alcohol dependent cases aged between 18- and 65-years fulfilling DSM-V criteria were recruited from the de-addiction centre. Blood donors (n=150) who had a history of alcohol intake with AUDIT score of less than eight were selected for the control group. The alleles were genotyped using TaqMan SNP genotyping assays by quantitative PCR. Association with alcohol dependence was evaluated with various genetic models using the Chi-square test. Multiple logistic regression analysis was performed to explore the effect of covariates. Results: The observed genotype frequency distributions of rs698 and rs671 were in agreement with Hardy Weinberg equilibrium (p>0.05).The dominant and allelic genetic model of ALDH2, rs671 between cases and controls showed a statistically significant association of the genetic variant with AD.

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“…These reports are contradictory to many studies across major global populations where ADH1C*1, Ile350 has been shown to lower the risk of AD [18]. The protective effect Ile350 is consistently reported in different Asian populations [18,36] than in non-Asian populations [24,[37][38][39] However, in a Turkish study, rs698 was not associated with AD whereas rs1229984 (Arg47His, also referred to as ADH1B*2) which is in high linkage disequilibrium with rs698 was associated with AD [40]. rs1229984 is also highly prevalent in Asian population but is rarely seen in non-Asians [6, 15,41].…”

Section: Discussionmentioning

confidence: 99%

Association between ALDH2 Variant and Alcohol Dependence in South Indian Population.

Umamageswari

Adithan

Manoharan

et al. 2021

Preprint

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Background: Alcohol dependence (AD) poses a serious medical problem and significant public health issue contributing to morbidity and mortality throughout the world. The aim of the study is to test the association of rs698 (ADH1C) and rs671(ALDH2) with the risk of alcohol dependence and to further assess the influence of environmental factors on altering the genetic susceptibility to alcoholism in south Indian Tamilian population.Methods& Results: A total of 150 alcohol dependent cases aged between 18- and 65-years fulfilling DSM-V criteria were recruited from de addiction center. Subjects in control group (n=150) had history of alcohol intake with AUDIT score less than 8. The alleles were genotyped using TaqMan SNP genotyping assays by quantitative PCR. Association with alcohol dependence was evaluated with various genetic models using chi-square test. Multiple logistic regression analysis was performed to explore the effect of covariates. The dominant (OR=0.5811,95% CI: 0.372-0.9224, p<0.01) and allelic genetic model (OR=0.6228,95% CI: 0.4328-0.9009, p<0.01) of ALDH2, rs671 between cases and controls showed a significant association of the genetic variant with AD. Multivariate logistic regression analysis revealed education level, family history, marital status were significantly associated with AD but there was no association between rs671 genotypes in the presence of these co-variates.Conclusions: Genetic factors play an important role in alcohol dependence. Combined analysis of functional genetic variants and environmental factors is warranted in future studies.

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Determination of the effects of Alcohol Dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey

Cited by 7 publications

References 29 publications

Allelic variations in alcohol metabolism genes (ADH1B, ADH1C, CYP2E1) and alcohol use disorder (AUD) in northeastern Brazil

Allelic variations in alcohol metabolism genes (ADH1B, ADH1C, CYP2E1) and alcohol use disorder (AUD) in northeastern Brazil

Association of ADH1C and ALDH2 genes with alcohol dependence in south Indian Tamilian population

Association between ALDH2 Variant and Alcohol Dependence in South Indian Population.

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