Our study was designed to determine whether the hormone and enzyme levels that we have mentioned in serum specimens can be used in postmortem examinations of the cases of hanging or not. Our research includes the postmortem results of the thyroid tissue pathologic examinations, serum levels of triiodothyronine (fT3), thyroxine (fT4), thyrotropin (TSH), thyroglobulin, parathormone (PTH), calcitonin, and amylase in cases of death due to hanging. The mean of fT3 and thyroglobulin levels were higher in hanging cases than those of sudden death cases. This difference was statistically significant (P < 0.05). In our study, we obtained data demonstrating that high postmortem levels of free T3 and thyroglobulin may be indicators of vital reaction in hanging cases. In such cases of death, it seems that applying pressure on the neck region where the thyroid gland is located causes the leakage of thyroglobulin as well as fT3, the active form of the thyroid hormone.
SummaryThis study was carried out on 70 patients with haematological or solid malignancies who were receiving chemotherapy and/or radiotherapy. Forty-one patients were randomly assigned to receive fluconazole, 400 mg/day, while they were neutropenic. Systemic fungal infection developed in four of the 41 patients (9%) receiving prophylaxis in comparison to nine of 29 patients (31%) not receiving prophylaxis. The incidence of systemic fungal infection was significantly different between the groups receiving prophylaxis and those not receiving it (p < 0.05). Fluconazole was found to be effective for preventing systemic fungal infections in neutropenic patients with cancer.
Neurobiological studies have shown that serotonergic dysfunction and disturbances in serotonin transmission are most frequently reported neurobiological substrates of suicidal behavior (Kamali et al., 2001;Hranilovic et al., 2003). The tryptophan hydroxylase (TPH) and the serotonin transporter (5-HTT) genes play a vital role in serotonin metabolism by coding the rate-limiting enzyme in serotonin biosynthesis and in serotonin neurotransmission by reclaiming synaptic serotonin, respectively. In previous studies, variations in these genes have been regarded as prime candidates in the susceptibility to suicidal behavior (Arango et al., 2003). In this study, we investigated both 5-HTTLPR (a 44-base pair insertion/ deletion functional polymorphism) and TPH (A218C) polymorphisms with suicidal behavior by comparing the allele and genotype distribution between suicide victims and normal controls. Liver tissue samples were obtained from 58 suicide victims (43 men, 15 women; average age 30.17 ± 13.07 years) at the Department of Forensic Medicine, Faculty of Medicine, Gazi University. Methods of suicide included hanging (n = 33), firearms (n = 18), fall from heights (n = 4), and drug overdose (n = 3). The medical records for each patient were subjected to retrospective and detailed review to extract demographic data and suicidal history. The control group consisted of 100 blood donors from a local hospital blood bank (52 men, 48 women; average age 35.0 ± 3.9 years) without any history of neuropsychiatric disorders (in their firstdegree and second-degree relatives). The study population consisted entirely of a Turkish population. Genotypes were determined for 58 completed suicide victims and 100 controls by using the polymerase chain reaction and restriction-fragment length polymorphism techni-ques. Statistical significance of differences between case and control group distributions for alleles and genotypes was determined using w 2 Fisher's exact tests. Statistical analyses were carried out using the SPSS package (SPSS standard version, release 10.0; SPSS Inc., Chicago, Illinois, USA). At the 5-HTTLPR locus, there were 49 long alleles (42.3%) and 67 (57.7%) short alleles in the suicide victim sample and 70 short alleles (35%) and 130 long alleles (65%) in the normal controls. The frequency of the A allele of the A218C polymorphism in TPH was 48 out of 116 (41.3%) in suicide cases and 90 out of 200 controls. The C allele frequency was 68 out of the total of 116 alleles in the suicide cases (58.7%) and 110 alleles out of the total 200 control alleles (55%). No association was found between the A218C polymorphism of the TPH gene (w 2 = 1.00; P = 0.60) and a 44-base pair insertion/ deletion functional polymorphism in the 5-HTTLPR (w 2 = 4.54; P = 0.10) and suicide. No significant genotypic or allelic association of the 5-HTTLPR and TPH polymorphisms with history of completed suicide was found. Gender-related analyses for these polymorphisms demonstrated no differences in allele frequencies and distributions between men and women...
Cinsel suçların cinsel dokunulmazlığına yönelik suç-lar başlığı altında toplanması nedeni ile bireysel hak ve özgürlükler açısından oldukça önemsenen ve 1 Haziran 2005 tarihinde yürürlüğe giren TCK (1), 102/5 ve 103/6. maddelerinde yer alan "ruh ve beden sağlığının bozulması" kavramı ile uygulamada sorunlara neden olmuş, dü-zenleme 28 Haziran 2014 tarihinde Resmi Gazete yayın-lanan 6545 sayılı Kanun ile değiştirilmiştir (2).Bilindiği gibi, cinsel saldırı gibi kişinin kendisini yaşamı boyunca etkileyebilecek ağır travmatik olaylar yaşanan bu olayla son bulmayıp, olaydan sonraki süreçte ÖzetAmaç: Cinsel suçlar, tüm dünyada her yaş grubundaki insanı tehdit eden toplumsal bir sorundur. Cinsel suçların, mağdurda birçok ruhsal hastalığa zemin hazırladığı bilinmektedir. Bu çalışmada, Ruh Sağlığı ve Hastalıkları Anabilim Dalı Erişkin Adli Kurul'da raporları düzenlenen cinsel saldırı mağdurlarının demografik özellikleri, suç konusu olayların özellikleri ve düzenlenen raporların sonuçları değer-lendirilerek literatürdeki diğer çalışmalarla karşılaştırılması amaçlandı.Gereç ve Yöntem: Adli Makamlar tarafından 2012 -2014 yıl-ları arasında EÜTF Ruh Sağlığı ve Hastalıkları Anabilim Dalı Eriş-kin Adli Kurul'a rapor düzenlenmesi nedeniyle dosyası ile birlikte gönderilen olgulara ait kayıtlar; olguların demografik özellikleri, rapor istem makamı, olayın türü ve tarihi, saldırgana ait bilgiler, olguların muayene bulguları ile düzenlenen raporların sonucu açıla-rından retrospektif olarak incelenerek, elde edilen veriler Windows için SPSS 18 istatistik programı ile değerlendirildi.Bulgular: 01 Ocak 2012 -31 Aralık 2014 tarihleri arasında rapor düzenlenen 311 olgunun 12'si (%3,9) erkek, 299'u (%96,1) kadındı. Olay tarihindeki yaşları 6 ila 89 arasında ve ortalaması 26,58+12,22 idi. Raporların %37'sinin (n=115) Ağır Ceza Mahkemeleri tarafından istendiği görüldü. Gerçekleştiği beyan edilen cinsel saldırıların %56,9'u (n=177) nitelikli olup, mağdurların %80,7'sinin (n=251) kendisinin şikâyetçi olduğu, saldırganların tümünün erkek olduğu, bunların %70,1'inin (n=218) mağdurun çevresindeki kişilerden olduğu tespit edildi. Olay sonucunda olguların %61,4'ünde (n=191) bir, %34,1'inde (n=106) ise birden fazla psikiyatrik bozukluk meydana geldiği saptandı.Sonuç: Cinsel saldırı mağdurlarında tespit edilen ruhsal rahatsızlıklar ile cinsel saldırıların her yaş grubundaki başta kadın ve çocuklara karşı, çoğu zaman erkekler tarafından gerçekleştirildiği bilgisi literatürdeki diğer çalışmalarla uyumlu bulunmuştur.Anahtar Kelimeler: Cinsel saldırı; Cinsel istismar; Ruh sağlı-ğının bozulması; Adli rapor. AbstractObjective: Sex crimes remain a social concern affecting people of all ages globally. It is known that sex crimes pave the way for many mental disturbances. In this study, it was aimed to investigate the demographics of sexual assault victims, features of sexual assaults and the results of the reports evaluated by Ege University Faculty of Medicine Adult Judicial Council and to compare those to other studies in literature.Materials and Methods:...
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