Determination of the effect of L. plantarum AB6-25, L. plantarum MK55 and S. boulardii T8-3C microorganisms on colon, cervix, and breast cancer cell lines: Molecular docking, and molecular dynamics study

Yalçınkaya, Seda; Azarkan, Serap Yalçın; Karahan, Aynur Gül

doi:10.1016/j.molstruc.2022.132939

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…70 After saving the ligand and protein structures in PDBQT format and entering the grid parameters, a Windows control system determined the calculation process and the binding energies (kcal mol −1 ). 71 Finally, the BIOVIA Discovery Studio 2016 Programme displayed the different interactions between the ligand and the receptor. 69…”

Section: Methodsmentioning

confidence: 99%

Computational approach: 3D-QSAR, molecular docking, ADMET, molecular dynamics simulation investigations, and retrosynthesis of some curcumin analogues as PARP-1 inhibitors targeting colon cancer

Zrinej,

Elmchichi,

Alaqarbeh

et al. 2023

New J. Chem.

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Section: Methodsmentioning

confidence: 99%

Computational approach: 3D-QSAR, molecular docking, ADMET, molecular dynamics simulation investigations, and retrosynthesis of some curcumin analogues as PARP-1 inhibitors targeting colon cancer

Zrinej,

Elmchichi,

Alaqarbeh

et al. 2023

New J. Chem.

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“…Upon reaching 80% con uency, the cells were wounded using a 20-200 µL pipette tip. Subsequently, 4 mL of fresh medium and 1 mL of metabolites were added [34]. The wound closure process was observed and imaged using an inverted microscope (BAB, Turkey).…”

Section: Determination Of Intracellular CD Levelmentioning

confidence: 99%

Evaluation of the protective effect of cannabidiol against cadmium-induced toxicity in 2D and 3D model THLE-2 liver cell line

Şahin,

Türksoy,

Azarkan

2024

Preprint

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The likelihood of human exposure to toxic metals is increasing due to various factors. Among these toxic metals, cadmium (Cd) holds a significant place. New methods and substances are needed to protect individuals against the harmful effects caused by Cd. In the Transformed Human Liver Epithelial-2 (THLE-2) cell line, the cytotoxic effect of Cd (IC50) was determined. To assess the protective efficacy of cannabidiol (CBD), some groups of cell lines were treated with Cd alone, while others were subjected to a combination of Cd and 5 µM CBD. GSH, MDA, MPO, CAT, TNF-α, IL-1β, and IL-6 levels in cell lines were determined using ELISA kits. The inhibition of toxic metal entry into the cells by CBD was evaluated through ICP-MS analysis. The IC50 value for Cd was determined as 5 µM in 2D cell lines and 10 µM in 3D cell lines. It was observed that the application of CBD at a concentration of 5 µM, along with the determined IC50 dose of Cd, increased the cell proliferation rate. Additionally, the decrease in GSH and CAT levels, and the increase in MDA, MPO, TNF-α, IL-1β, and IL-6 levels observed in cell lines treated only with Cd were reversed with the application of CBD. The ICP-MS analysis revealed that CBD reduced the uptake of Cd into the cells. CBD reverses the oxidative stress and inflammation caused by Cd, increases cell proliferation, and reduces Cd entry into the cell. This provides strong evidence for the protective role of CBD against Cd exposures.

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Properties and stability of Lactiplantibacillus plantarum AB6-25 and Saccharomyces boulardii T8-3C single and double-layered microcapsules containing Na-alginate and/or demineralized whey powder with lactobionic acid

Gedik,

Karahan

2024

International Journal of Biological Macromolecules

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Determination of the effect of L. plantarum AB6-25, L. plantarum MK55 and S. boulardii T8-3C microorganisms on colon, cervix, and breast cancer cell lines: Molecular docking, and molecular dynamics study

Cited by 3 publications

References 37 publications

Computational approach: 3D-QSAR, molecular docking, ADMET, molecular dynamics simulation investigations, and retrosynthesis of some curcumin analogues as PARP-1 inhibitors targeting colon cancer

Computational approach: 3D-QSAR, molecular docking, ADMET, molecular dynamics simulation investigations, and retrosynthesis of some curcumin analogues as PARP-1 inhibitors targeting colon cancer

Evaluation of the protective effect of cannabidiol against cadmium-induced toxicity in 2D and 3D model THLE-2 liver cell line

Properties and stability of Lactiplantibacillus plantarum AB6-25 and Saccharomyces boulardii T8-3C single and double-layered microcapsules containing Na-alginate and/or demineralized whey powder with lactobionic acid

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