Determination of the Conversion Products of Toxic organophosphorus substances in Construction Materials Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Leninskii, M. A.; Savelieva, Elena; Karakashev, G. V.; Vasilieva, I. A.; Samchenko, N. A.

doi:10.1134/s1061934822130020

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Repeatability was conducted using six different preparations individually of the target concentration of the intended method 100% (500 µg/mL) of Tho using the same equipment on the same day via the same analyst or compared with another analyst as inter–precision 11 – 13 , 34 , 35 , 38 .…”

Section: Methodology and Experimental Analysismentioning

confidence: 99%

Rapidly, sensitive quantitative assessment of thiopental via forced stability indicating validated RP-HPLC method and its in-use stability activities

Al-Hakkani

Ahmed²,

Hassan

2023

Sci Rep

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Thiopental sodium (Tho) is an intravenous anesthetic. The current study aimed to find a rapid RP-HPLC method of Tho analysis with high linearity, repeatability, sensitivity, selectivity, and inexpensive. In our developed method, there is no need to use special chemical reagents, a high percentage of organic solvent, a high flow rate, or a further guard column. The chromatographic system consists of an ODS column (150 mm × 4.6 mm × 5 μm). The mobile phase was prepared by mixing KH2PO4 solution: methanol (40:60) with a flow rate of 1.2 mL/min at a detection wavelength of 230 nm, at room temperature using an injection volume of 10 μL. The method manifested a satisfied linearity regression R2 (0.9997) with a good repeatability precision range (0.16–0.47%) with LOD and LOQ; 14.4 μg/mL and 43.6 μg/mL respectively. Additionally, the method proved its efficiency via system suitability achievement in robustness and ruggedness, according to the validation guidelines. The shorter analysis time makes the method very valuable in quality control to quantify the commercial Tho in pharmaceutical preparations. This improved HPLC method has been successfully applied for Tho analysis for Thiopental UP Pharma 500 mg vials and Thiopental Eipico 1.0 g vials in our routine finished and stability studies testing laboratories. Additionally, the detection limit of Tho has been tested in our quality control lab to detect the smallest amount of traces that may be present after the cleaning process of the production machines for cephalosporins preparations. The method has shown positive results for Tho in low-level raw materials and pharmaceutical formulations.

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Section: Methodology and Experimental Analysismentioning

confidence: 99%

Rapidly, sensitive quantitative assessment of thiopental via forced stability indicating validated RP-HPLC method and its in-use stability activities

Al-Hakkani

Ahmed²,

Hassan

2023

Sci Rep

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“…This insight is pivotal for improving asphalt formulations and enhancing road durability. Another paper performed by [188] employed high-performance liquid chromatography coupled with tandem mass spectrometry to detect toxic organophosphorus compounds in construction materials. Their work underscores chromatography's sensitivity and precision in identifying hazardous substances, contributing to safer construction practices by ensuring materials are free from harmful contaminants.…”

Section: Chromatography: Used To Separate and Analyze Compounds That ...mentioning

confidence: 99%

Experimental Techniques for Testing the Properties of Construction Materials

Habib,

AL Houri,

Al-Toubat

et al. 2024

Preprint

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The field of construction materials is pivotal in developing sustainable and resilient infrastructure. This demands continuous research to understand the properties and behaviors of these materials under diverse conditions. Although advancements in material science and numerical modeling have been significant, experimental testing remains indispensable for a thorough comprehension of material characteristics, particularly under extreme stresses and environmental factors. This need has forced the development of a wide array of testing techniques, each designed to evaluate specific engineering properties, thus creating a complex and varied landscape of experimental methodologies. This study provides a comprehensive overview of both conventional and innovative experimental testing techniques used to characterize construction materials. It explores the related methodologies and identifies potential gaps in their application within the industry. The spectrum of testing covered includes mechanical, chemical, thermal, microstructural, durability, physical, rheological properties, and non-destructive testing methods. Mechanical tests assess strength, hardness, and fatigue, whereas chemical analyses utilize techniques such as spectroscopy and chromatography. Thermal properties are examined using thermogravimetric analysis, and microstructural characteristics are explored through advanced imaging techniques. Durability testing focuses on materials’ resistance to environmental challenges, while physical properties tests evaluate aspects like porosity and water absorption. Rheological and non-destructive tests further examine materials’ behavior and integrity without causing damage. By discussing these methodologies, the study sheds light on various approaches to material evaluation and aims to enhance the selection, application, and development of testing standards. This overview seeks to inform and inspire future research and innovation in the science of construction materials, contributing to the development of more resilient and sustainable construction practices.

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Determination of the Conversion Products of Toxic organophosphorus substances in Construction Materials Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Cited by 2 publications

References 18 publications

Rapidly, sensitive quantitative assessment of thiopental via forced stability indicating validated RP-HPLC method and its in-use stability activities

Rapidly, sensitive quantitative assessment of thiopental via forced stability indicating validated RP-HPLC method and its in-use stability activities

Experimental Techniques for Testing the Properties of Construction Materials

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