Determination of the analgesic dose–response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients

Herman, N.; Sheu, Kevin L; Decar, Tama K. Van; J, Rubin; Gadalla, Farida; Koff, Howard; Reynolds, John E.

doi:10.1016/s0952-8180(98)00113-5

Cited by 22 publications

(13 citation statements)

References 12 publications

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“…Epidural fentanyl and sufentanil have been considered to be equivalent at ratios varying from 5:1 [9], 5.7:1 [10], 5.9:1 [7], to 6.3:1 [11]. The type of study design, or the low precision of most of these studies, might explain these discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia

Lilker

Rofaeel

Balki

et al. 2009

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 99%

Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia

Lilker

Rofaeel

Balki

et al. 2009

Journal of Clinical Anesthesia

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“…10 The potency ratio of epidural sufentanil:fentanyl was reported as 5:1 by Herman et al and 5.9:1 by Capogna et al, and they observed less side effects like somnolence and pruritus with sufentanil compared to fentanyl. 6,7 Sufentanil is preferred for epidural administration because of its high lipid solubility and high affinity for mu opioid receptors. It penetrates to spinal cord rapidly, leaving cerebrospinal fluid and this prevents the delayed respiratory depression.…”

Section: Group 1 Group 2 Pmentioning

confidence: 99%

“…Sufentanil is the most potent opioid. [2][3][4][5][6][7] Bupivacaine and sufentanil are frequently used together. 1,[8][9][10] However, the lowest doses that produce effective analgesia is still controversial.…”

mentioning

confidence: 99%

Comparison of Two Different Bupivacaine Doses with Sufentanil for Epidural Obstetric Analgesia

Çakirca¹,

Bektaş²,

Özcan³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : Addition of opioids to local anesthetics for epidural obstetric analgesia provides effective analgesia with decreased side effects. We compared the analgesic quality of 0,0625% bupivacaine and 0,1% bupivacaine with 0.5 μg/mL sufentanil. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Study participants were 18-45-year-old, primiparous 30 parturients. An epidural catheter was placed, 8-10 mL of 0.0625% bupivacaine with 0.5 μg/mL sufentanil and 0.1% bupivacaine with 0.5 μg/mL sufentanil were given to Group I and Group II, respectively. Hemodynamic parameters, obstetric examination findings, pain grades, time to reach visual analog scale (VAS)<4 and the first dose interval were recorded. Satisfaction levels, motor and sensorial blocks, oxytocin and valetamate bromide consumption, side effects were assessed. Total and additional drug use, duration of second stage of the delivery, mean delivery times, instrumental delivery, Apgar scores, fetal heart rates and uterine contraction pressures were recorded. The percentage of participation of the parturients to the delivery was assessed. R Re es su ul lt ts s: : Median VAS values were significantly lower in Group II. Median VAS values were lower than 4 in both groups after 15 th minute. The time to the second analgesic dose was longer in Group II. Systolic, diastolic and mean arterial blood pressures were measured lower in Group II. Satisfaction scores were significantly higher in Group II. C Co on nc cl lu us si io on n: : In the present study, satisfactory analgesia was produced in both groups. Although median VAS scores were lower in Group II, VAS<4 could be reached in Group I. We concluded that 0.0625% bupivacaine+0.5 μg/mL sufentanil combination, as providing VAS<4, could be a preferable alternative to 0.1% bupivacaine+0.5 μg/mL sufentanil. K Ke ey y W Wo or rd ds s: : Analgesia, obstetrical; analgesia, epidural Ö ÖZ ZE ET T A Am ma aç ç: : Epidural obstetrik analjezi için lokal anesteziklere opioidlerin eklenmesi daha efektif bir analjezi sağlar ve yan etkileri azaltır. Biz bu çalışmada %0,0625 bupivakain ve %0,1 bupivakaine 0,5 mikrog/mL sufentanil ekleyerek analjezi kalitesini karşılaştırdık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya, 18-45 yaşları arasında, 30 primipar gebe dahil edildi. Epidural kateter yerleştirildikten sonra %0,0625 bupivakain ile 0,5 mikrog/mL sufentanil veya %0,1 bupivakain ile 0,5 mikrog/mL sufentanil sırasıyla Grup I ve Grup II olarak belirlendi ve 8-10 mL uygulandı. Hemodinamik parametreler, obstetrik muayene bulguları, ağrı düzeyleri, vizuel analo skala (VAS)<4 olma zamanı ve ilk analjezik gereksinim zamanı kayıt edildi. Memnuniyet dereceleri, motor ve duyusal blok, oksitosin ve valetamat bromür kullanımı ve yan etkiler değerlendirildi. Toplam ve ek ilaç kullanımı, doğumun 2. evresinin süresi, doğumun toplam süresi, doğumda yardımcı alet kullanımı, Apgar skorları, fetal kalp hızı ve uterin kontraksiyon basınçları kayıt edildi. Gebelerin doğuma katılı...

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“…Epidural methadone in dogs undergoing pelvic limb surgical procedures resulted in greater decreases in the EtISO required to maintain anesthesia compared with the same doses administered intravenously 2 . Other opioids are also used with the same goal, such as fentanyl 3,4 , sufentanil 5,6 , oxymorphone 7 , and especially morphine 1,[8][9][10][11] . Epidural use of morphine has been limited though because of the dose-dependent risk of delayed respiratory depression and/or potential urinary retention requires close monitoring of respiratory patterns, which is not always possible in dogs 11,12 and humans 13 .…”

Section: Introductionmentioning

confidence: 99%

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Frazílio

DeRossi²,

Jardim³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. METHODS:Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic. RESULTS:A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose. CONCLUSION:Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.

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Determination of the analgesic dose–response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients

Cited by 22 publications

References 12 publications

Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia

Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia

Comparison of Two Different Bupivacaine Doses with Sufentanil for Epidural Obstetric Analgesia

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

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